{"id":16898,"date":"2014-07-16T10:25:31","date_gmt":"2014-07-16T08:25:31","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=16898"},"modified":"2014-07-16T10:27:12","modified_gmt":"2014-07-16T08:27:12","slug":"nova-slinivka-brisni-ma-byt-novou-nadeji-pro-diabetiky","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=16898","title":{"rendered":"Nov\u00e1 slinivka b\u0159i\u0161n\u00ed m\u00e1 b\u00fdt novou nad\u011bj\u00ed pro diabetiky"},"content":{"rendered":"

Je to tenk\u00e1 polymerov\u00e1 deska, sotva v\u011bt\u0161\u00ed ne\u017e c\u00e9d\u00e9\u010dko. Implantovan\u00e1 do b\u0159icha by mohla zm\u011bnit \u017eivot milion\u016f diabetik\u016f z\u00e1visl\u00fdch na inzulinu. Um\u011bl\u00e1 slinivka b\u0159i\u0161n\u00ed, vyvinut\u00e1 francouzsk\u00fdmi v\u011bdci, bude v r. 2016 poprv\u00e9 testov\u00e1na u \u010dlov\u011bka, p\u00ed\u0161e agentura AFP.<\/strong><\/p>\n

S t\u00edmto za\u0159\u00edzen\u00edm si pacienti u\u017e nebudou muset p\u00edchat injekce inzulinu: hormon budou p\u0159irozenou cestou produkovat bu\u0148ky slinivky b\u0159i\u0161n\u00ed z\u00edskan\u00e9 genetick\u00fdm in\u017een\u00fdrstv\u00edm nebo z kmenov\u00fdch bun\u011bk. Bu\u0148ky budou um\u00edst\u011bny uvnit\u0159 desti\u010dky.<\/p>\n

\"ilustra\u010dn\u00ed<\/a>
ilustra\u010dn\u00ed foto: puravida \/ MorgueFile<\/figcaption><\/figure>\n

Tento projekt, jeho\u017e \u0161irok\u00e9 vyu\u017eit\u00ed se o\u010dek\u00e1v\u00e1 a\u017e po roce 2020, vyvol\u00e1v\u00e1 mnoho nad\u011bj\u00ed a o\u010dek\u00e1v\u00e1n\u00ed pro 25 milion\u016f osob s diabetem prvn\u00edho typu ve sv\u011bt\u011b, uv\u00e1d\u00ed S\u00e9verine Sigristov\u00e1 z francouzsk\u00e9 spole\u010dnosti Defymed, kter\u00e1 na tomto prototypu pracuje.<\/p>\n

My\u0161lenka um\u011bl\u00e9 slinivky s biologick\u00fdmi prvky se zrodila p\u0159i v\u00fdzkumu s transplantacemi bun\u011bk slinivky b\u0159i\u0161n\u00ed ur\u010den\u00fdch k tomu, aby nahradily nemocnou slinivku pacient\u016f a umo\u017enily jejich organismu znovu produkovat inzulin a regulovat tak hladinu cukru v krvi. Ov\u0161em vzhledem k nedostatku transplant\u00e1t\u016f m\u016f\u017ee tuto techniku vyu\u017e\u00edvat jen nepatrn\u00e1 men\u0161ina pacient\u016f. A p\u0159edev\u0161\u00edm je p\u0159i n\u00ed nutno nasadit l\u00e9\u010dbu zamezuj\u00edc\u00ed tomu, aby t\u011blo transplant\u00e1t odm\u00edtalo, a ta m\u00e1 velmi v\u00e1\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky.<\/p>\n

„Z toho vznikla my\u0161lenka vyvinout jakousi krabi\u010dku, v n\u00ed\u017e by byly um\u00edst\u011bny bu\u0148ky slinivky b\u0159i\u0161n\u00ed tak, aby byly uchr\u00e1n\u011bny p\u0159ed \u00fatoky imunitn\u00edho syst\u00e9mu,“ vysv\u011btluje Sigristov\u00e1.<\/p>\n

Bylo tedy t\u0159eba vytvo\u0159it jakousi zpola propustnou membr\u00e1nu, kter\u00e1 takovou ochranu umo\u017en\u00ed, a p\u0159itom j\u00ed bude moci proch\u00e1zet inzul\u00edn, ale i cukry, aby bu\u0148ky slinivky „v\u011bd\u011bly“, jak\u00e9 mno\u017estv\u00ed inzulinu produkovat.<\/p>\n

Polymerov\u00e1 desti\u010dka bude implantov\u00e1na do b\u0159icha p\u0159i kr\u00e1tk\u00e9m chirurgick\u00e9m z\u00e1kroku. Po \u010dty\u0159ech a\u017e \u0161esti letech ji bude t\u0159eba vym\u011bnit. Uvnit\u0159 se budou bu\u0148ky slinivky obnovovat pomoc\u00ed podko\u017en\u00ed injekce aplikovan\u00e9 po \u0161esti a\u017e dvan\u00e1cti m\u011bs\u00edc\u00edch. Takov\u00e1 frekvence je nesrovnateln\u00e1 s t\u00edm, jak dnes diabetici musej\u00ed vpichovat inzulin n\u011bkolikr\u00e1t denn\u011b.<\/p>\n

Zdokonalov\u00e1n\u00ed t\u00e9to membr\u00e1ny si vy\u017e\u00e1dalo 20 let v\u00fdzkumu a n\u00e1klady ve v\u00fd\u0161i \u0161esti milion\u016f eur (162 milion\u016f K\u010d). Koncem roku 2015 nebo po\u010d\u00e1tkem roku 2016 se v jihofrancouzsk\u00e9m Montpellier a v britsk\u00e9m Oxfordu zah\u00e1j\u00ed testy na 16 dobrovoln\u00edc\u00edch. Prvn\u00ed v\u00fdsledky by m\u011bly b\u00fdt k dispozici koncem roku 2017.<\/p>\n

Pokud budou \u00fasp\u011b\u0161n\u00e9, diabetici by mohli b\u00fdt zbaveni ka\u017edodenn\u00ed nutnosti p\u00edchat si inzul\u00edn. „Dosavadn\u00ed l\u00e9\u010dba je sice \u00fa\u010dinn\u00e1, ale dlouhodob\u011b m\u016f\u017ee v\u00e9st ke komplikac\u00edm, zvl\u00e1\u0161t\u011b pokud jde o srdce a mozek. Na\u0161\u00edm c\u00edlem je rovn\u011b\u017e tyto komplikace odstranit,“ zd\u016fraz\u0148uje Michel Pinget z Evropsk\u00e9 asociace pro studium diabetu (EASD), kter\u00e1 \u0159\u00edd\u00ed tento projekt ve \u0160trasburku.<\/p>\n

Diabetolog v\u0161ak upozor\u0148uje, \u017ee tento projekt neznamen\u00e1 vyl\u00e9\u010den\u00ed pacient\u016f. Pole aplikace t\u011bchto v\u00fdzkum\u016f je mnohem \u0161ir\u0161\u00ed, nebo\u0165 choroba ve vysp\u011bl\u00fdch zem\u00edch v\u00fdrazn\u011b postupuje, dod\u00e1v\u00e1.<\/p>\n

V roce 2010 bylo v Evrop\u011b m\u011bs\u00ed\u010dn\u011b registrov\u00e1no 1850 nov\u00fdch p\u0159\u00edpad\u016f, tedy \u0161estkr\u00e1t v\u00edce ne\u017e v 90. letech. Z dosud t\u00e9m\u011b\u0159 nejasn\u00fdch p\u0159\u00ed\u010din vznik\u00e1 diabetes v \u010d\u00edm d\u00e1l t\u00edm ni\u017e\u0161\u00edm v\u011bku. Je\u0161t\u011b p\u0159ed n\u011bkolika lety se pr\u016fm\u011brn\u00fd v\u011bk, kdy se cukrovka projevila, pohyboval mezi p\u011bti a patn\u00e1cti lety, zat\u00edmco dnes to je hned po narozen\u00ed do p\u00e1t\u00e9ho roku, uv\u00e1d\u00ed doktor Pinget.<\/p>\n","protected":false},"excerpt":{"rendered":"

Je to tenk\u00e1 polymerov\u00e1 deska, sotva v\u011bt\u0161\u00ed ne\u017e c\u00e9d\u00e9\u010dko. Implantovan\u00e1 do b\u0159icha by mohla zm\u011bnit \u017eivot milion\u016f diabetik\u016f z\u00e1visl\u00fdch na inzulinu. Um\u011bl\u00e1 slinivka b\u0159i\u0161n\u00ed, vyvinut\u00e1 […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14161,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-16898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/16898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16898"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/16898\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14161"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}