{"id":17321,"date":"2014-08-28T23:40:25","date_gmt":"2014-08-28T21:40:25","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=17321"},"modified":"2014-08-28T23:50:05","modified_gmt":"2014-08-28T21:50:05","slug":"kmenove-bunky-mohou-pomoci-lidem-s-als-na-niz-neni-lek","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=17321","title":{"rendered":"Kmenov\u00e9 bu\u0148ky pomohou lidem s ALS, na ni\u017e nen\u00ed l\u00e9k"},"content":{"rendered":"

Kmenov\u00e9 bu\u0148ky kostn\u00ed d\u0159en\u011b mohou m\u00edt p\u0159\u00edzniv\u00fd \u00fa\u010dinek na pr\u016fb\u011bh amyotrofick\u00e9 later\u00e1ln\u00ed skler\u00f3zy (ALS), neurodegenerativn\u00edho onemocn\u011bn\u00ed, kter\u00e9 vede b\u011bhem dvou a\u017e p\u011bti let ke smrti pacienta a na n\u011b\u017e nen\u00ed l\u00e9k.<\/strong> <\/p>\n

K tomuto z\u00e1v\u011bru, kter\u00fd byl nyn\u00ed zve\u0159ejn\u011bn v presti\u017en\u00edm mezin\u00e1rodn\u00edm l\u00e9ka\u0159sk\u00e9m \u010dasopise Stem Cells, dosp\u011bl t\u00fdm v\u011bdc\u016f \u00dastavu experiment\u00e1ln\u00ed medic\u00edny Akademie v\u011bd (AV) veden\u00fd profesorkou Evou Sykovou.<\/p>\n

Podle publikovan\u00fdch v\u00fdsledk\u016f zpomalilo pod\u00e1n\u00ed lidsk\u00fdch kmenov\u00fdch bun\u011bk kostn\u00ed d\u0159en\u011b do mozkom\u00ed\u0161n\u00edho moku v p\u00e1te\u0159n\u00edm kan\u00e1lku u laboratorn\u00edch zv\u00ed\u0159at ub\u00fdv\u00e1n\u00ed svalstva a zv\u00fd\u0161ilo po\u010det p\u0159e\u017e\u00edvaj\u00edc\u00edch motorick\u00fdch neuron\u016f, je\u017e inervuj\u00ed kostern\u00ed sval.<\/p>\n

Zpomalilo tak\u00e9 rozpad nervov\u00fdch s\u00edt\u00ed obaluj\u00edc\u00edch tyto neurony, sn\u00ed\u017eilo m\u00edru z\u00e1niku nervov\u00fdch bun\u011bk v oblasti kr\u010dn\u00ed m\u00edchy a zv\u00fd\u0161ilo hladinu cytokin\u016f IL1-alfa a MCP1, protein\u016f, je\u017e maj\u00ed pod\u00edl na imunitn\u00ed odpov\u011bdi a mohou hr\u00e1t v\u00fdznamnou roli v pr\u016fb\u011bhu onemocn\u011bn\u00ed.<\/p>\n

„V\u00fdsledkem aplikace bun\u011bk je zpomalen\u00ed pr\u016fb\u011bhu choroby, konkr\u00e9tn\u011b o 37 procent del\u0161\u00ed p\u0159e\u017eit\u00ed zv\u00ed\u0159at od vypuknut\u00ed choroby,“ shrnula v\u011bdkyn\u011b.<\/p>\n

Pen\u00edze na l\u00e9\u010dbu tohoto z\u00e1va\u017en\u00e9ho onemocn\u011bn\u00ed sb\u00edr\u00e1 nyn\u00ed ve\u0159ejnost na cel\u00e9m sv\u011bt\u011b v kampani na soci\u00e1ln\u00edch s\u00edt\u00edch. Lid\u00e9 bu\u010f maj\u00ed zve\u0159ejnit video, jak si nech\u00e1vaj\u00ed hlavu pol\u00edt v\u011bdrem studen\u00e9 vody, a vyzvat dal\u0161\u00ed lidi, aby je do 24 hodin n\u00e1sledovali nebo v\u011bnovali na konto boje s ALS sto dolar\u016f.<\/p>\n

V\u00fdsledky t\u00fdmu z AV podporuj\u00ed dal\u0161\u00ed postup klinick\u00e9 studie ve Fakultn\u00ed nemocnici Motol, kterou vypracovali v\u011bdci \u00fastavu a schv\u00e1lil ji St\u00e1tn\u00ed \u00fastav pro kontrolu l\u00e9\u010div. T\u00fdm bude nyn\u00ed zkoumat, zda dal\u0161\u00edho zpomalen\u00ed pr\u016fb\u011bhu ALS je mo\u017en\u00e9 dos\u00e1hnout pomoc\u00ed opakovan\u00e9ho pod\u00e1n\u00ed kmenov\u00fdch bun\u011bk.<\/p>\n

ALS, zn\u00e1m\u00e1 tak\u00e9 jako Lou Gehrigova choroba \u010di nemoc motoneuronu, zp\u016fsobuje degeneraci a ztr\u00e1tu bun\u011bk centr\u00e1ln\u00ed nervov\u00e9 soustavy, kter\u00e9 ovl\u00e1daj\u00ed v\u016fl\u00ed ovlivniteln\u00e9 svalov\u00e9 pohyby. Mozek nakonec nen\u00ed schopen ovl\u00e1dat v\u011bt\u0161inu sval\u016f a pacient je paralyzov\u00e1n, p\u0159i zachov\u00e1n\u00ed psychick\u00fdch a ment\u00e1ln\u00edch schopnost\u00ed. P\u0159\u00edznaky po\u010d\u00ednaj\u00edc\u00ed choroby jsou svalov\u00e1 slabost, zvl\u00e1\u0161t\u011b v rukou a nohou, a posti\u017een\u00ed \u0159e\u010di, polyk\u00e1n\u00ed a d\u00fdch\u00e1n\u00ed.<\/p>\n

Nemoc\u00ed trp\u00ed \u0161est ze 100.000 lid\u00ed, ro\u010dn\u011b se na tento po\u010det lid\u00ed zjist\u00ed dva nov\u00e9 p\u0159\u00edpady. ALS postihla nap\u0159\u00edklad slavn\u00e9ho britsk\u00e9ho astrofyzika a matematika Stephena Hawkinga (foto).<\/p>\n","protected":false},"excerpt":{"rendered":"

Kmenov\u00e9 bu\u0148ky kostn\u00ed d\u0159en\u011b mohou m\u00edt p\u0159\u00edzniv\u00fd \u00fa\u010dinek na pr\u016fb\u011bh amyotrofick\u00e9 later\u00e1ln\u00ed skler\u00f3zy (ALS), neurodegenerativn\u00edho onemocn\u011bn\u00ed, kter\u00e9 vede b\u011bhem dvou a\u017e p\u011bti let ke smrti […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":10622,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-17321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/17321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17321"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/17321\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/10622"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}