{"id":18894,"date":"2014-12-11T11:56:44","date_gmt":"2014-12-11T10:56:44","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=18894"},"modified":"2014-12-11T11:58:14","modified_gmt":"2014-12-11T10:58:14","slug":"test-na-rakovinu-prostaty-bude-podobny-tehotenskemu","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=18894","title":{"rendered":"Test na rakovinu prostaty bude mo\u017en\u00e9 si d\u011blat i doma"},"content":{"rendered":"

Brn\u011bn\u0161t\u00ed v\u011bdci zkoumaj\u00ed l\u00e1tku sarkosin. V\u00fdsledkem v\u00fdzkumu je test, kter\u00fd dok\u00e1\u017ee u mu\u017e\u016f rychle, jednodu\u0161e a bez bolesti odhalit rakovinu prostaty, a to i doma. V podstat\u011b bude podobn\u00fd t\u011bhotensk\u00e9mu testu. <\/strong>
\n<\/p>\n

foto: CENTRUM TRANSFERU TECHNOLOGI\u00cd – MENDELOVA UNIVERZITA V BRN\u011a<\/p>\n

Rakovina prostaty<\/strong> je nej\u010dast\u011bj\u0161\u00edm typem zhoubn\u00e9ho n\u00e1dorov\u00e9ho onemocn\u011bn\u00ed \u010desk\u00fdch mu\u017e\u016f a nemocn\u00fdch ka\u017edoro\u010dn\u011b o dv\u011b a\u017e t\u0159i procenta p\u0159ib\u00fdv\u00e1. Odhalit karcinom prostaty p\u0159itom nen\u00ed a\u017e tak jednoduch\u00e9. Vy\u0161et\u0159en\u00ed prob\u00edh\u00e1 v\u017edy u l\u00e9ka\u0159e a pro pacienta je stanoven\u00ed diagn\u00f3zy nep\u0159\u00edjemn\u00e9 a \u010dasto bolestiv\u00e9. Spolehliv\u00e9 v\u00fdsledky odhal\u00ed a\u017e rozbor odebran\u00e9 tk\u00e1n\u011b z prostaty. V\u011bdci z Laborato\u0159e metalomiky a nanotechnologi\u00ed Mendelovy univerzity v Brn\u011b \u010dty\u0159i roky zkoumali l\u00e1tku zvanou sarkosin. V\u00fdsledkem jejich v\u00fdzkumu je test podobn\u00fd t\u011bhotensk\u00e9mu. M\u00e1 upozornit mu\u017ee na ne\u017e\u00e1douc\u00ed zm\u011bny jejich prostaty a v\u010dasnou n\u00e1v\u0161t\u011bvu l\u00e9ka\u0159e. M\u016f\u017ee tak pomoci v\u010das odhalit p\u0159edev\u0161\u00edm agresivn\u00ed formy rakoviny.<\/p>\n

Vy\u0161et\u0159en\u00ed per rektum \u2013 tedy pohmatem p\u0159es kone\u010dn\u00edk, a \u0159ada laboratorn\u00edch test\u016f. Tak dnes vypad\u00e1 pro mu\u017ee n\u00e1ro\u010dn\u00e1 a p\u0159esto ne zcela spolehliv\u00e1 diagnostika karcinomu prostaty. Jistou diagn\u00f3zu poskytne a\u017e biopsie, kdy se jehlou p\u0159es kone\u010dn\u00edk odebere vzorek tk\u00e1n\u011b prostaty.<\/p>\n

I kv\u016fli nekomfortnosti t\u011bchto vy\u0161et\u0159en\u00ed mu\u017ei \u010dasto n\u00e1v\u0161t\u011bvu u l\u00e9ka\u0159e odkl\u00e1daj\u00ed. Varovn\u00e9 sign\u00e1ly, jako jsou \u010dast\u00e9 mo\u010den\u00ed \u010di pocit ne\u00fapln\u011b vypr\u00e1zdn\u011bn\u00e9ho m\u011bch\u00fd\u0159e, jsou toti\u017e shodn\u00e9 jako u zbytn\u011bn\u00ed prostaty – nemoci, kter\u00e1 po pades\u00e1t\u00e9m roce \u017eivota ztrp\u010duje \u017eit\u00ed polovin\u011b mu\u017esk\u00e9 populace. P\u0159ehl\u00ed\u017een\u00ed t\u011bchto p\u0159\u00edznak\u016f v\u0161ak m\u016f\u017ee b\u00fdt nebezpe\u010dn\u00e9 p\u0159edev\u0161\u00edm u agresivn\u00edch forem karcinomu pror\u016fstaj\u00edc\u00edch do kost\u00ed.<\/p>\n

V\u011bdci z Mendelovy univerzity v Brn\u011b vyv\u00edj\u00ed zp\u016fsob, jak mohou mu\u017ei jednodu\u0161e, rychle a spolehliv\u011b sami sledovat, zda jejich prostata vykazuje ne\u017e\u00e1douc\u00ed zm\u011bny. Pomoci jim v tom m\u00e1 test podobn\u00fd t\u011bhotensk\u00e9mu.<\/p>\n

V\u00fdsledky jednodu\u0161e z mo\u010di<\/p>\n

V\u011bdci z Laborato\u0159e Metalomiky a nanotechnologi\u00ed si vzali na pomoc aminokyselinu zvanou sarkosin. Jej\u00ed p\u0159\u00edtomnost v mo\u010di u zhoubn\u00fdch n\u00e1dor\u016f prostaty objevili v\u011bdci z Michigansk\u00e9 univerzity teprve p\u0159ed p\u011bti lety.<\/p>\n

V\u011bdeck\u00fd t\u00fdm profesora Ren\u00e9ho Kizka \u010dty\u0159i roky prov\u00e1d\u011bl v\u00fdzkum, jeho\u017e c\u00edlem bylo prok\u00e1zat, zda je sarkosin spolehliv\u00fdm vod\u00edtkem k ur\u010den\u00ed p\u0159edev\u0161\u00edm zhoubn\u00fdch n\u00e1dor\u016f prostaty. V\u011bdci sledovali mno\u017estv\u00ed sarkosinu v mo\u010di pacient\u016f s r\u016fzn\u00fdmi n\u00e1dory prostaty a srovn\u00e1vali je se zdrav\u00fdmi jedinci. \u201eV\u00fdsledky, kter\u00e9 jsme anal\u00fdzou vzork\u016f mo\u010di z\u00edskali p\u0159ibli\u017en\u011b od 500 pacient\u016f, ukazuj\u00ed, \u017ee sarkosin skute\u010dn\u011b m\u016f\u017ee slou\u017eit jako diagnosticky velmi efektivn\u00ed molekula. Velkou v\u00fdhodou je nav\u00edc jeho jednoduch\u00e1 anal\u00fdza,\u201c \u0159\u00edk\u00e1 Zbyn\u011bk Heger, pracovn\u00edk Laborato\u0159e metalomiky a nanotechnologi\u00ed, kter\u00fd se na v\u00fdzkumu pod\u00edlel.<\/p>\n

V sou\u010dasn\u00e9 dob\u011b se diagnostika tohoto typu n\u00e1doru zakl\u00e1d\u00e1 na stanoven\u00ed prostatick\u00e9ho specifick\u00e9ho antigenu v krevn\u00edm s\u00e9ru. Tento zp\u016fsob diagnostiky je spolehliv\u00fd jen asi na 70 a\u017e 80 procent a \u010dasto tak doch\u00e1z\u00ed k fale\u0161n\u011b pozitivn\u00edm \u010di negativn\u00edm v\u00fdsledk\u016fm. Biopsii se pak zbyte\u010dn\u011b podrobuje a\u017e 30 procent pacient\u016f. V\u00fdzkum brn\u011bnsk\u00fdch v\u011bdc\u016f, kter\u00fd potvrzuje d\u016fle\u017eitost sarkosinu p\u0159i \u00fa\u010dinn\u00e9 diagn\u00f3ze v\u00fdskytu p\u0159edev\u0161\u00edm agresivn\u011bj\u0161\u00edch forem n\u00e1dor\u016f prostaty z mo\u010di, je pro pacienty i l\u00e9ka\u0159e velmi v\u00fdznamn\u00fd.<\/p>\n

Kdy bude prepar\u00e1t na trhu?<\/p>\n

Brn\u011bn\u0161t\u00ed v\u011bdci pl\u00e1nuj\u00ed zhotoven\u00ed jednoduch\u00e9ho a levn\u00e9ho testu, kter\u00fd mohou mu\u017ei pou\u017e\u00edvat sami z domova. Z\u00e1kladn\u00ed p\u0159edstavu, jak by m\u011bl test vypadat, u\u017e maj\u00ed. \u201eV sou\u010dasn\u00e9 dob\u011b hled\u00e1me partnera z komer\u010dn\u00ed sf\u00e9ry, kter\u00fd by tester uvedl na trh. Jednali jsme u\u017e s n\u011bkolika zahrani\u010dn\u00edmi firmami, zat\u00edm ne\u00fasp\u011b\u0161n\u011b,\u201c konstatuje Robert Plaga, \u0159editel Centra transferu technologi\u00ed Mendelovy univerzity v Brn\u011b.<\/p>\n

Podle v\u011bdc\u016f bude tento test ur\u010den\u00fd p\u0159edev\u0161\u00edm pro dom\u00e1c\u00ed pou\u017eit\u00ed. M\u00e1 upozornit mu\u017ee na patologick\u00e9 zv\u00fd\u0161en\u00ed sarkosinu v jejich mo\u010di a v\u010dasnou n\u00e1v\u0161t\u011bvu l\u00e9ka\u0159e, \u010d\u00edm\u017e m\u016f\u017ee pomoci zv\u00fd\u0161it z\u00e1chyt p\u0159edev\u0161\u00edm agresivn\u00edch karcinom\u016f prostaty.<\/p>\n

P\u0159elomov\u00fd v\u00fdznam pro poopera\u010dn\u00ed progn\u00f3zu<\/p>\n

Vyvinut\u00ed jednoduch\u00e9ho testeru pro dom\u00e1c\u00ed pou\u017eit\u00ed v\u0161ak nen\u00ed jedin\u00fdm c\u00edlem brn\u011bnsk\u00fdch v\u011bdc\u016f. V Laborato\u0159i metalomiky a nanotechnologi\u00ed z\u00e1rove\u0148 b\u011b\u017e\u00ed experiment\u00e1ln\u00ed pr\u00e1ce, kter\u00e1 zkoum\u00e1, nakolik m\u016f\u017ee sarkosin odhadnout poopera\u010dn\u00ed progn\u00f3zu pacienta. \u201eJde o pacienty, kter\u00fdm byla prostata opera\u010dn\u011b odstran\u011bna. Ukazuje se, \u017ee mu\u017ei, kter\u00fdm se n\u00e1dor po z\u00e1kroku vr\u00e1til, m\u011bli p\u0159ed operac\u00ed zv\u00fd\u0161enou koncentraci sarkosinu oproti t\u011bm, kte\u0159\u00ed se po odebr\u00e1n\u00ed prostaty zcela uzdravili,\u201c \u0159\u00edk\u00e1 Zbyn\u011bk Heger.<\/p>\n

Pokud v\u00fdzkum prok\u00e1\u017ee vliv sarkosinu p\u0159i rozli\u0161en\u00ed agresivn\u00edch forem n\u00e1dor\u016f proti m\u00edrn\u011bj\u0161\u00edm typ\u016fm je\u0161t\u011b p\u0159ed operac\u00ed, bude pro l\u00e9ka\u0159e v\u00fdznamn\u00fdm vod\u00edtkem pro pl\u00e1nov\u00e1n\u00ed dal\u0161\u00ed poopera\u010dn\u00ed l\u00e9\u010dby v\u010detn\u011b rozhodnut\u00ed, zda je pro pacienta n\u00e1sledn\u00e1 chemoterapie nutn\u00e1, \u010di nikoliv. Tento jev je p\u0159edm\u011btem dal\u0161\u00edho zkoum\u00e1n\u00ed.<\/p>\n

Dlouhodob\u00fd v\u00fdzkum prob\u00edh\u00e1 ve spolupr\u00e1ci s urologick\u00fdmi odd\u011blen\u00edmi fakultn\u00edch nemocnic v pra\u017esk\u00e9m Motole a u svat\u00e9 Anny v Brn\u011b. Pro potvrzen\u00ed v\u00fdznamu sarkosinu v odborn\u00e9 diagnostice karcinom\u016f prostaty cht\u011bj\u00ed brn\u011bn\u0161t\u00ed v\u011bdci vyhodnotit je\u0161t\u011b velk\u00e9 mno\u017estv\u00ed vzork\u016f. Z toho d\u016fvodu hledaj\u00ed zahrani\u010dn\u00ed partnery, mezi kter\u00e9 ji\u017e pat\u0159\u00ed nemocnice v N\u011bmecku a Rakousku, je\u017e p\u0159isl\u00edbily, \u017ee budou laborato\u0159 vzorky mo\u010di z\u00e1sobovat.<\/p>\n

Denisa Ranochov\u00e1
\nTiskov\u00e1 zpr\u00e1va – Centrum transferu technologi\u00ed Mendelovy univerzity v Brn\u011b<\/p>\n","protected":false},"excerpt":{"rendered":"

Brn\u011bn\u0161t\u00ed v\u011bdci zkoumaj\u00ed l\u00e1tku sarkosin. V\u00fdsledkem v\u00fdzkumu je test, kter\u00fd dok\u00e1\u017ee u mu\u017e\u016f rychle, jednodu\u0161e a bez bolesti odhalit rakovinu prostaty, a to i doma. […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":18908,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,9],"tags":[],"class_list":["post-18894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/18894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18894"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/18894\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/18908"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}