{"id":19009,"date":"2014-12-18T15:34:25","date_gmt":"2014-12-18T14:34:25","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=19009"},"modified":"2014-12-18T15:34:25","modified_gmt":"2014-12-18T14:34:25","slug":"objev-roku-hradecti-vedci-nasli-nove-lecivo","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=19009","title":{"rendered":"Objev roku. Hrade\u010dt\u00ed v\u011bdci na\u0161li nov\u00e9 l\u00e9\u010divo"},"content":{"rendered":"

Revolu\u010dn\u00ed objev. Pr\u00e1v\u011b tak se d\u00e1 hovo\u0159it o pr\u00e1ci v\u011bdeck\u00e9ho t\u00fdmu z Hradce Kr\u00e1lov\u00e9, kter\u00fd po n\u011bkolika letech v\u00fdzkumu p\u0159ipravil nov\u00fd typ l\u00e9\u010diva na Alzheimerovu chorobu.<\/strong><\/p>\n

Hradec Kr\u00e1lov\u00e9 \u2013 V\u011bdci maj\u00ed nyn\u00ed podanou p\u0159ihl\u00e1\u0161ku na \u010desk\u00fd patent l\u00e9ku, u\u017e v tuto chv\u00edli se o n\u011bj ale zaj\u00edmaj\u00ed p\u0159edn\u00ed sv\u011btov\u00e9 odborn\u00e9 \u010dasopisy.<\/p>\n

Ale p\u011bkn\u011b popo\u0159\u00e1dku. Na co vlastn\u011b hrade\u010dt\u00ed v\u011bdci p\u0159i\u0161li? Nov\u00fd typ l\u00e9\u010diva by m\u011bl vylep\u0161it aktu\u00e1ln\u00ed l\u00e9ky, kter\u00e9 u\u017e\u00edvaj\u00ed lid\u00e9 s Alzheimerovou chorobou. L\u00e9ky, kter\u00e9 jsou v tuto chv\u00edli na trhu, nejsou p\u0159\u00edli\u0161 komplexn\u00ed. Nov\u00fd medikament se sna\u017e\u00ed zas\u00e1hnout v\u00edce c\u00edl\u016f najednou, a hlavn\u011b co nejv\u00edce omezit ne\u017e\u00e1douc\u00ed \u00fa\u010dinky spojen\u00e9 s jeho pod\u00e1v\u00e1n\u00edm. „L\u00e9\u010diva jsou potenci\u00e1ln\u011b vyu\u017eiteln\u00e1 pro l\u00e9\u010dbu Alzheimerovy choroby. Ne\u0159e\u0161\u00ed samoz\u0159ejm\u011b probl\u00e9m, kdy by \u010dlov\u011bka z nemoci vyl\u00e9\u010dila \u00fapln\u011b, ale d\u00e1vaj\u00ed si za c\u00edl postihnout v\u00edce patologick\u00fdch projev\u016f dan\u00e9 nemoci,“ up\u0159es\u0148uje Jan Kor\u00e1be\u010dn\u00fd z Katedry toxikologie a vojensk\u00e9 farmacie Fakulty vojensk\u00e9ho zdravotnictv\u00ed, kter\u00fd v\u011bdeck\u00fd t\u00fdm vedl. Spolupracoval na n\u011bm s Centrem biomedic\u00ednsk\u00e9ho v\u00fdzkumu Fakultn\u00ed nemocnice Hradec Kr\u00e1lov\u00e9 a z\u00e1rove\u0148 s v\u011bdci z It\u00e1lie a Slovenska.<\/p>\n

P\u016fvodn\u011b hledali protijed pro voj\u00e1ky<\/p>\n

Jan Kor\u00e1be\u010dn\u00fd za\u010dal s v\u00fdzkumem u\u017e v roce 2008. Tak trochu paradoxn\u00ed je, \u017ee vyu\u017eil poznatk\u016f, kter\u00e9 se Alzheimerovy choroby v\u016fbec net\u00fdkaly. „Na Fakult\u011b vojensk\u00e9ho zdravotnictv\u00ed se dlouhodob\u011b pracovalo s nervov\u011b paralytick\u00fdmi l\u00e1tkami, jako je nap\u0159\u00edklad sarin, ke kter\u00e9mu se hledali r\u016fzn\u00e9 protijedy. V\u00fdsledky v\u00fdzkumu jsme pou\u017eili pr\u00e1v\u011b p\u0159i objevov\u00e1n\u00ed l\u00e9\u010diva Alzheimerovy choroby,“ vysv\u011btluje s \u00fasm\u011bvem v\u011bdec.
\nT\u00fdm expert\u016f pracoval s p\u016fvodn\u011b vyvinut\u00fdm l\u00e9\u010divem na „Alzheimera“ \u2013 takrinem. Ten ale byl sta\u017een z trhu kv\u016fli sv\u00fdm z\u00e1va\u017en\u00fdm vedlej\u0161\u00edm \u00fa\u010dink\u016fm.<\/p>\n

Kdy se l\u00e9k dostane na trh? \u010cek\u00e1 ho je\u0161t\u011b dlouh\u00e1 cesta<\/p>\n

P\u0159i u\u017e\u00edv\u00e1n\u00ed „star\u00e9ho“ l\u00e9ku na Alzheimerovu chorobu byla nap\u0159\u00edklad nam\u011b\u0159ena vysok\u00e1 toxicita na j\u00e1tra. „Vzali jsme p\u0159edlohu takrinu, jeho\u017e struktura je dob\u0159e obm\u011bniteln\u00e1, a sna\u017eili jsme se ji spojit s n\u011b\u010d\u00edm, co by molekule dalo dal\u0161\u00ed p\u0159idanou hodnotu,“ popisuje \u00fasp\u011b\u0161n\u00fd v\u00fdzkum Jan Kor\u00e1be\u010dn\u00fd. V\u0161echny studie, kter\u00e9 se zkou\u0161ely nap\u0159\u00edklad i na zv\u00ed\u0159atech, prok\u00e1zaly, \u017ee je nov\u00fd l\u00e9k v porovn\u00e1n\u00ed se star\u00fdm mnohem m\u00e9n\u011b toxick\u00fd.
\nV\u00fdzkumu, o kter\u00e9m se nyn\u00ed p\u00ed\u0161e po cel\u00e9m sv\u011bt\u011b, v\u0161ak p\u0159edch\u00e1zela zdlouhav\u00e1 p\u0159\u00edprava. „Nejt\u011b\u017e\u0161\u00ed ze v\u0161eho bylo sesum\u00edrovat poznatky toho, co u\u017e je ve sv\u011bt\u011b zn\u00e1mo a co by se dalo d\u011blat,“ p\u0159izn\u00e1v\u00e1 hradeck\u00fd v\u011bdec. P\u0159\u00edprava samotn\u00e9ho l\u00e9\u010diva v laborato\u0159i pak prob\u00edhala tak, \u017ee se st\u00e1le dokola „zkou\u0161elo“ co bude fungovat a co ne.<\/p>\n

Objevem l\u00e9\u010diva v\u0161e teprve za\u010d\u00edn\u00e1<\/p>\n

\u00dasp\u011b\u0161n\u00fdm objevem medikamentu cesta ale ani zdaleka nekon\u010d\u00ed. Ne\u017e se l\u00e9k dostane na pulty l\u00e9k\u00e1ren, potrv\u00e1 to je\u0161t\u011b dlouhou dobu. Od synt\u00e9zy po jeho zaveden\u00ed na trh toti\u017e uplyne zhruba dvan\u00e1ct a\u017e patn\u00e1ct let, nyn\u00ed se d\u00e1 mluvit o prvn\u00edm roce. Cel\u00fd proces nav\u00edc stoj\u00ed a\u017e jednu miliardu americk\u00fdch dolar\u016f.<\/p>\n

„Uvid\u00edme, jestli se patentu, kter\u00fd pr\u00e1v\u011b pod\u00e1v\u00e1me, chytne n\u011bjak\u00e1 firma. D\u00e1l u\u017e se z finan\u010dn\u00edch d\u016fvod\u016f na tomto v\u00fdzkumu pod\u00edlet nebudeme,“ uzav\u00edr\u00e1 mlad\u00fd doktor a dod\u00e1v\u00e1, \u017ee v sou\u010dasnosti m\u00e1 jeho v\u011bdeck\u00fd t\u00fdm rozjeto hned n\u011bkolik dal\u0161\u00edch slibn\u00fdch l\u00e1tek. Op\u011bt se t\u00fdkaj\u00ed v\u00fdzkumu l\u00e1tky takrin.<\/p>\n

—<\/p>\n

Alzheimerovou chorobou trp\u00ed v \u010cesku p\u0159es 100 tis\u00edc lid\u00ed<\/p>\n

Alzheimerova choroba je posti\u017een\u00ed centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu, tedy mozku, p\u0159i n\u011bm\u017e doch\u00e1z\u00ed k postupn\u00e9 demenci. Nemoc v\u0161ak za\u010d\u00edn\u00e1 pozvolna. \u010clov\u011bk zapom\u00edn\u00e1, trp\u00ed prostorovou dezorientac\u00ed, je zmaten\u00fd, d\u011bl\u00e1 mu probl\u00e9m nap\u0159\u00edklad vyjad\u0159ov\u00e1n\u00ed. Pr\u016fb\u011bh je v\u0161ak u ka\u017ed\u00e9ho velmi individu\u00e1ln\u00ed. Alzheimerova choroba se ve v\u011bt\u0161in\u011b p\u0159\u00edpad\u016f t\u00fdk\u00e1 star\u00fdch lid\u00ed, v \u010cesk\u00e9 republice j\u00ed trp\u00ed p\u0159es 100 tis\u00edc osob. Sou\u010dasn\u00e1 v\u011bda nem\u00e1 \u017e\u00e1dn\u00fd l\u00e9k, kter\u00fd by ji dok\u00e1zal \u00fapln\u011b vyl\u00e9\u010dit.<\/p>\n

V\u011bdec Jan Kor\u00e1be\u010dn\u00fd<\/p>\n

Jan Kor\u00e1be\u010dn\u00fd vystudoval Farmaceutickou fakultu v Hradci Kr\u00e1lov\u00e9 v roce 2008. O \u010dty\u0159i roky pozd\u011bji zde \u00fasp\u011b\u0161n\u011b obh\u00e1jil doktorskou pr\u00e1ci na kated\u0159e Farmaceutick\u00e9 chemie a kontroly l\u00e9\u010div ve spolupr\u00e1ci s Fakultou vojensk\u00e9ho zdravotnictv\u00ed. V sou\u010dasn\u00e9 dob\u011b pracuje jako akademick\u00fd pracovn\u00edk na Kated\u0159e toxikologie a vojensk\u00e9 farmacie a na Centru biomedic\u00ednsk\u00e9ho v\u00fdzkumu ve Fakultn\u00ed nemocnici Hradec Kr\u00e1lov\u00e9. Jeho oblast v\u00fdzkumu zahrnuje krom\u011b v\u00fdvoje nov\u00fdch l\u00e9\u010div pro l\u00e9\u010dbu Alzheimerovy choroby i v\u00fdzkum protin\u00e1dorov\u00fdch l\u00e9\u010div. Spole\u010dn\u011b se sv\u00fdm t\u00fdmem p\u0159ipravil nov\u00fd typ l\u00e9\u010diva na Alzheimerovu chorobu, na kter\u00fd je nyn\u00ed podan\u00e1 p\u0159ihl\u00e1\u0161ka na \u010desk\u00fd patent l\u00e9ku.<\/p>\n

http:\/\/hradecky.denik.cz\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Revolu\u010dn\u00ed objev. Pr\u00e1v\u011b tak se d\u00e1 hovo\u0159it o pr\u00e1ci v\u011bdeck\u00e9ho t\u00fdmu z Hradce Kr\u00e1lov\u00e9, kter\u00fd po n\u011bkolika letech v\u00fdzkumu p\u0159ipravil nov\u00fd typ l\u00e9\u010diva na Alzheimerovu […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14127,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-19009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/19009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19009"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/19009\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14127"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}