{"id":21675,"date":"2015-06-09T10:15:29","date_gmt":"2015-06-09T08:15:29","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=21675"},"modified":"2015-06-09T10:15:29","modified_gmt":"2015-06-09T08:15:29","slug":"zlepseni-videni-po-genove-lecbe-slepoty-je-zatim-jen-docasne","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=21675","title":{"rendered":"Zlep\u0161en\u00ed vid\u011bn\u00ed po genov\u00e9 l\u00e9\u010db\u011b slepoty je zat\u00edm jen do\u010dasn\u00e9"},"content":{"rendered":"<p><strong>Ameri\u010dt\u00ed v\u011bdci zaznamenali v l\u00e9\u010db\u011b slepoty \u00fasp\u011bch, i kdy\u017e jen do\u010dasn\u00fd. K v\u00fdrazn\u00e9mu zlep\u0161en\u00ed zraku toti\u017e sice do\u0161lo a\u017e na obdob\u00ed n\u011bkolika let, ale pak se za\u010dal op\u011bt zhor\u0161ovat.\u00a0\u00a0 <\/strong><!--more--><\/p>\n<p>Renomovan\u00fd l\u00e9ka\u0159sk\u00fd \u010dasopis New England Journal of Medicine informoval o studii v\u011bdc\u016f z University of Pennsylvania o v\u00fdsledc\u00edch genov\u00e9 l\u00e9\u010dby Leberovy kongenit\u00e1ln\u00ed amaur\u00f3zy &#8211; jedn\u00e9 z geneticky zap\u0159\u00ed\u010din\u011bn\u00fdch onemocn\u011bn\u00ed s\u00edtnice znamenaj\u00edc\u00edch do\u017eivotn\u00ed slepotu.<\/p>\n<p>Asi 10 procent lid\u00ed s touto slepotou m\u00e1 mutaci genu RPE65, podle kter\u00e9ho je v s\u00edtnici &#8222;vyr\u00e1b\u011bna&#8220; b\u00edlkovina, kter\u00e1 je d\u016fle\u017eit\u00e1 pro spr\u00e1vnou funkci s\u00edtnicov\u00fdch bun\u011bk. P\u0159i poru\u0161e tohoto genu v\u0161ak doch\u00e1z\u00ed k odum\u00edr\u00e1n\u00ed bun\u011bk s\u00edtnice a ke ztr\u00e1t\u011b zraku.<\/p>\n<p>V\u011bdci provedli genovou l\u00e9\u010dbu u patn\u00e1cti lid\u00ed s t\u00edmto typem slepoty (Leberovou kongenit\u00e1ln\u00ed amaur\u00f3zou) v roce 2007. Pomoc\u00ed virov\u00e9ho nosi\u010de vpravili do bun\u011bk s\u00edtnice spr\u00e1vn\u00fd gen RPE65.<\/p>\n<p>U\u017e po n\u011bkolika dnech pozorovali n\u011bkte\u0159\u00ed pacienti v\u00fdznamn\u00e9 zlep\u0161en\u00ed zraku. Krom\u011b zv\u00fd\u0161en\u00e9 citlivosti ke sv\u011btlu za\u010dali \u010dty\u0159i pacienti vyu\u017e\u00edvat \u010d\u00e1st s\u00edtnice, kter\u00e1 byla opravena funk\u010dn\u00edm genem, k vn\u00edm\u00e1n\u00ed ost\u0159ej\u0161\u00edho obrazu. Dok\u00e1zali nap\u0159\u00edklad \u010d\u00edst velk\u00e1 p\u00edsmena.<\/p>\n<p>Zlep\u0161en\u00e9 vid\u011bn\u00ed opraven\u00e9 \u010d\u00e1sti s\u00edtnice se udr\u017eelo \u0159adu m\u011bs\u00edc\u016f a u n\u011bkter\u00fdch pacient\u016f p\u0159etrv\u00e1valo i n\u011bkolik let.<\/p>\n<p>Anal\u00fdza zraku t\u011bchto lid\u00ed ale uk\u00e1zala, \u017ee i kdy\u017e doch\u00e1z\u00ed a\u017e n\u011bkolik let k postupn\u00e9mu n\u00e1r\u016fstu ostrosti zraku, za n\u011bkolik let po l\u00e9\u010db\u011b za\u010dne ostrost zraku zase pozvolna klesat.<\/p>\n<p>Zjistilo se tak\u00e9, \u017ee se \u00fabytek bun\u011bk s\u00edtnice po genov\u00e9 l\u00e9\u010db\u011b nezastavil a pokra\u010doval nezm\u011bn\u011bn\u00fdm tempem. A to p\u0159esto, \u017ee prokazateln\u011b do\u0161lo ke zlep\u0161en\u00ed zraku po l\u00e9\u010db\u011b, kter\u00e9 bylo vyvol\u00e1no pozitivn\u00edm \u00fa\u010dinkem funk\u010dn\u00edho genu na funkce p\u0159e\u017e\u00edvaj\u00edc\u00edch s\u00edtnicov\u00fdch bun\u011bk.<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Ameri\u010dt\u00ed v\u011bdci zaznamenali v l\u00e9\u010db\u011b slepoty \u00fasp\u011bch, i kdy\u017e jen do\u010dasn\u00fd. K v\u00fdrazn\u00e9mu zlep\u0161en\u00ed zraku toti\u017e sice do\u0161lo a\u017e na obdob\u00ed n\u011bkolika let, ale pak <a class=\"mh-excerpt-more\" href=\"https:\/\/www.invarena.cz\/?p=21675\" title=\"Zlep\u0161en\u00ed vid\u011bn\u00ed po genov\u00e9 l\u00e9\u010db\u011b slepoty je zat\u00edm jen do\u010dasn\u00e9\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":21567,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-21675","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/21675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21675"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/21675\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/21567"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}