{"id":23580,"date":"2015-11-20T19:41:56","date_gmt":"2015-11-20T18:41:56","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=23580"},"modified":"2015-11-20T19:41:56","modified_gmt":"2015-11-20T18:41:56","slug":"kmenove-bunky-mohou-zpomalit-postup-als","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=23580","title":{"rendered":"Kmenov\u00e9 bu\u0148ky mohou zpomalit postup ALS"},"content":{"rendered":"

Zahrani\u010dn\u00ed studie z roku 2015 potvrdila, \u017ee kmenov\u00e9 bu\u0148ky mohou zpomalit postup ALS<\/strong><\/p>\n

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Amyotrofick\u00e1 later\u00e1ln\u00ed skler\u00f3za (ALS) je smrteln\u00e9 nevyl\u00e9\u010diteln\u00e9 neurodegenerativn\u00ed onemocn\u011bn\u00ed mozku a m\u00edchy, u kter\u00e9ho je statisticky ov\u011b\u0159eno, \u017ee l\u00e9\u010dbou l\u00e9ky doch\u00e1z\u00ed k prodlou\u017een\u00ed \u017eivota o t\u0159i a\u017e \u0161est m\u011bs\u00edc\u016f.<\/p>\n

L\u00e9\u010dba kmenov\u00fdmi bu\u0148kami dle v\u00fdsledk\u016f v\u011bdeck\u00e9 studie ukazuje, \u017ee tato metoda p\u0159in\u00e1\u0161\u00ed zkvalitn\u011bn\u00ed a prodlou\u017een\u00ed \u017eivota pacient\u016f s ALS s lep\u0161\u00edm efektem a v del\u0161\u00edm \u010dasov\u00e9m horizontu.<\/p>\n

Obdobn\u00e9 z\u00e1v\u011bry vykazuj\u00ed i dal\u0161\u00ed nez\u00e1visl\u00e9 studie. I p\u0159es tyto p\u0159\u00edzniv\u00e9 v\u00fdsledky je l\u00e9\u010dba kmenov\u00fdmi bu\u0148kami st\u00e1le ve f\u00e1zi klinick\u00e9ho v\u00fdzkumu, a proto nen\u00ed hrazen\u00e1 st\u00e1tem a na jej\u00edm financov\u00e1n\u00ed se pod\u00edl\u00ed r\u016fzn\u00e9 soukrom\u00e9 subjekty.<\/p>\n

Nemoc\u00ed ALS trp\u00ed v cel\u00e9m sv\u011bt\u011b stovky tis\u00edc osob. V \u010cesk\u00e9 republice jsou to stovky nemocn\u00fdch. Na 100 tis\u00edc osob p\u0159ipad\u00e1 \u0161est lid\u00ed, kte\u0159\u00ed maj\u00ed ALS a ka\u017ed\u00fd rok onemocn\u00ed dal\u0161\u00ed dv\u011b osoby z populace 100 tis\u00edc obyvatel. Nemoc zp\u016fsobuje degeneraci a ztr\u00e1tu mozkov\u00fdch a m\u00ed\u0161n\u00edch motoneuron\u016f, tj. bun\u011bk centr\u00e1ln\u00ed nervov\u00e9 soustavy, kter\u00e9 ovl\u00e1daj\u00ed v\u016fl\u00ed ovlivniteln\u00e9 svalov\u00e9 pohyby.<\/p>\n

Kv\u016fli tomu doch\u00e1z\u00ed k postupn\u00e9 svalov\u00e9 slabosti a\u017e atrofii. Mozek nakonec nen\u00ed schopen ovl\u00e1dat v\u011bt\u0161inu sval\u016f a pacient z\u016fst\u00e1v\u00e1 paralyzov\u00e1n, p\u0159i zachov\u00e1n\u00ed psychick\u00fdch a ment\u00e1ln\u00edch schopnost\u00ed. Rychlost, jakou nemoc postupuje, je individu\u00e1ln\u00ed. Pr\u016fm\u011brn\u00e1 doba trv\u00e1n\u00ed nemoci se uv\u00e1d\u00ed 2 a\u017e 4,3 let, p\u0159i\u010dem\u017e:<\/p>\n

– zhruba 25 procent pacient\u016f p\u0159e\u017eije 5 let<\/p>\n

– 8 a\u017e 16 procent pacient\u016f p\u0159e\u017eije 10 let<\/p>\n

– 5 procent pacient\u016f \u017eije 20 let.<\/p>\n

L\u00e9\u010dba ALS se zam\u011b\u0159uje na prodlou\u017een\u00ed kvality a d\u00e9lky \u017eivota pacienta, nebo\u0165 nemoc nen\u00ed sou\u010dasnou l\u00e9ka\u0159skou v\u011bdou l\u00e9\u010diteln\u00e1.<\/p>\n

Prof. MUDr. Eva Sykov\u00e1, DrSc., FCMA, \u0159editelka \u00dastavu experiment\u00e1ln\u00ed medic\u00edny AV \u010cR, v. v. i. vysv\u011btluje: „Je nutn\u00e9 si uv\u011bdomit, \u017ee u ALS bohu\u017eel nejde o vyl\u00e9\u010den\u00ed nemocn\u00e9ho, to sou\u010dasn\u00e1 medic\u00edna neum\u00ed. C\u00edlem je zlep\u0161it kvalitu \u017eivota a prodlou\u017eit jej. Zlep\u0161en\u00ed kvality \u017eivota pacienta m\u016f\u017ee p\u0159edstavovat v\u00fdznamn\u00fd benefit, dojde-li nap\u0159\u00edklad k zlep\u0161en\u00ed pohyblivosti cel\u00e9ho t\u011bla, mluven\u00ed, \u010di polyk\u00e1n\u00ed. Pro zdrav\u00e9ho \u010dlov\u011bka zcela b\u011b\u017en\u00e9 v\u011bci, ale pro nemocn\u00e9ho ALS naprosto z\u00e1sadn\u00ed zm\u011bny k lep\u0161\u00edmu pro\u017eit\u00ed ka\u017ed\u00e9ho dne. Druh\u00fdm p\u0159\u00ednosem je pak prodlou\u017een\u00ed \u017eivota. L\u00e9\u010dba ALS pomoc\u00ed kmenov\u00fdch bun\u011bk nab\u00edz\u00ed zat\u00edm nejlep\u0161\u00ed v\u00fdsledky, potvrzen\u00e9 mnoha experiment\u00e1ln\u00edmi studiemi i publikovan\u00fdmi klinick\u00fdmi v\u00fdsledky, proto jsme se rozhodli zp\u0159\u00edstupnit tuto l\u00e9\u010dbu nemocn\u00fdm, i kdy\u017e jej\u00ed pozitivn\u00ed efekt m\u016f\u017ee b\u00fdt pro jednoho pacienta v\u011bt\u0161\u00ed a pro druh\u00e9ho men\u0161\u00ed.“<\/p>\n<\/div>\n

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\u00daSTAV EXPERIMENT\u00c1LN\u00cd MEDIC\u00cdNY Akademie v\u011bd \u010cR, v. v. i. (\u00daEM) je sv\u011btov\u011b uzn\u00e1van\u00fdm centrem z\u00e1kladn\u00edho biomedic\u00ednsk\u00e9ho v\u00fdzkumu a m\u00e1 status Centra excellence EU – MEDIPRA. C\u00edlem jeho \u010dinnosti je vyv\u00edjet l\u00e9\u010debn\u00e9 postupy a techniky aplikovateln\u00e9 v mnoha oborech klinick\u00e9 praxe. horoby srde\u010dn\u00ed<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Zahrani\u010dn\u00ed studie z roku 2015 potvrdila, \u017ee kmenov\u00e9 bu\u0148ky mohou zpomalit postup ALS<\/p>\n<\/div>","protected":false},"author":1,"featured_media":904,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-23580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/23580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23580"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/23580\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/904"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}