{"id":24894,"date":"2016-03-11T11:35:21","date_gmt":"2016-03-11T10:35:21","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=24894"},"modified":"2016-03-12T07:40:03","modified_gmt":"2016-03-12T06:40:03","slug":"prvni-biologickou-lecbou-byl-humulin-na-cukrovku","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=24894","title":{"rendered":"Prvn\u00ed biologickou l\u00e9\u010dbou byl humulin na cukrovku"},"content":{"rendered":"<p><strong>Klinika pom\u00e1h\u00e1 pacient\u016fm s lup\u00e9nkou, s artr\u00f3zou kolen, ky\u010dl\u00ed, p\u00e1te\u0159e, ale i lidem po infarktu myokardu, \u010di c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b<\/strong> <!--more--><\/p>\n<p>Pardubice \u2013 V roce 2004 bylo v Pardubic\u00edch zalo\u017eeno Centrum pro klinick\u00fd a z\u00e1kladn\u00ed v\u00fdzkum, kter\u00e9 nab\u00edz\u00ed pacient\u016fm biologickou l\u00e9\u010dbu. Podobn\u00e1 za\u0159\u00edzen\u00ed pracuj\u00ed je\u0161t\u011b v Praze, v Brn\u011b a otev\u0159en\u00ed dal\u0161\u00edho se chyst\u00e1 v Ostrav\u011b. O t\u00e9to ojedin\u011bl\u00e9 l\u00e9\u010db\u011b s Den\u00edkem hovo\u0159il MUDr. TOM\u00c1\u0160 H\u00c1LA z pardubick\u00e9 kliniky CCBR.<\/p>\n<p>&#8211; Co je biologick\u00e1 l\u00e9\u010dba?<\/p>\n<p>L\u00e9\u010dba, b\u011bhem n\u00ed\u017e jsou pacient\u016fm pod\u00e1v\u00e1ny l\u00e1tky, kter\u00e9 zasahuj\u00ed do imunitn\u00edch a z\u00e1n\u011btliv\u00fdch d\u011bj\u016f v t\u011ble a t\u00edm ovliv\u0148uj\u00ed vznik a v\u00fdvoj chorob.<\/p>\n<p>&#8211; Odkdy se biologick\u00e1 l\u00e9\u010dba v medic\u00edn\u011b pou\u017e\u00edv\u00e1?<\/p>\n<p>Jako prvn\u00ed biologick\u00e9 l\u00e9\u010divo byl pod\u00e1n humulin (inzulin) v 80. letech 20. stolet\u00ed k l\u00e9\u010db\u011b cukrovky. N\u00e1sledovaly dal\u0161\u00ed l\u00e1tky jako interferony k l\u00e9\u010db\u011b \u017eloutenky nebo roztrou\u0161en\u00e9 skler\u00f3zy, erytropoetin k l\u00e9\u010db\u011b an\u00e9mie. Na za\u010d\u00e1tku 21. stolet\u00ed nastoupily monoklon\u00e1ln\u00ed protil\u00e1tky, jejich\u017e v\u00fdvoj a pou\u017eit\u00ed jde velmi rychle vp\u0159ed a jsou nej\u010dast\u011bji pou\u017e\u00edvanou formou biologick\u00e9 l\u00e9\u010dby dodnes. Nejv\u00edce se pou\u017e\u00edvaj\u00ed v onkologii, revmatologii, dermatologii, gastroenterologii, neurologii, ale i v jin\u00fdch oborech.<\/p>\n<p>&#8211; V \u010dem je biologick\u00e1 l\u00e9\u010dba unik\u00e1tn\u00ed?<\/p>\n<p>Zvl\u00e1\u0161tnost\u00ed biologick\u00e9 l\u00e9\u010dby je jej\u00ed p\u016fvod. L\u00e1tky, kter\u00e9 se k l\u00e9\u010db\u011b pou\u017e\u00edvaj\u00ed, jsou zalo\u017eeny na biologick\u00e9m p\u016fvodu \u2013 \u00fa\u010dinn\u00e1 l\u00e1tka je bu\u010f produktem \u017eiv\u00e9ho organismu nebo ze \u017eiv\u00e9ho organismu vych\u00e1z\u00ed (r\u016fzn\u00e9 toxiny, antitoxiny, produkty \u017eiv\u00fdch \u010di usmrcen\u00fdch organism\u016f, s\u00e9ra, org\u00e1ny nebo tk\u00e1n\u011b rostlinn\u00e9ho i \u017eivo\u010di\u0161n\u00e9ho p\u016fvodu). Proto n\u00e1zev biologick\u00e1 l\u00e9\u010dba. Dal\u0161\u00ed velkou v\u00fdhodou biologick\u00e9 l\u00e9\u010dby je jej\u00ed c\u00edlen\u00e9 p\u016fsoben\u00ed. Biologick\u00e1 l\u00e9\u010dba je zac\u00edlen\u00e1 pouze na molekuly nebo pochody, kter\u00e9 jsou jen v nemocn\u00fdch bu\u0148k\u00e1ch a v norm\u00e1ln\u00edch bu\u0148k\u00e1ch se bu\u010f nevyskytuj\u00ed nebo jen v mal\u00e9 m\u00ed\u0159e. T\u00edm, \u017ee biologick\u00e1 l\u00e9\u010dba p\u016fsob\u00ed jen na nemocn\u00e9 bu\u0148ky a &#8222;norm\u00e1ln\u00ed&#8220; zdrav\u00e9 bu\u0148ky neovliv\u0148uje nebo jen v minim\u00e1ln\u00ed m\u00ed\u0159e, zp\u016fsobuje m\u00e9n\u011b v\u00fdznamn\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, kter\u00e9 obvykle rychle odezn\u00ed. P\u0159\u00edkladem t\u011bchto ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f jsou: tzv. ch\u0159ipkov\u00e9 p\u0159\u00edznaky \u2013 hore\u010dka, bolesti hlavy a sval\u016f, alergick\u00e9 reakce v m\u00edst\u011b vpichu \u2013 za\u010derven\u00e1n\u00ed, bolestivost, sv\u011bd\u011bn\u00ed, otok.<\/p>\n<p>&#8211; Pro\u010d je biologick\u00e1 l\u00e9\u010dba sm\u011b\u0159ov\u00e1na jen do specializovan\u00fdch center?<\/p>\n<p>Biologick\u00e1 l\u00e9\u010dba je vysoce n\u00e1kladn\u00e1 a tyto n\u00e1klady st\u00e1le rostou do stovek mili\u00f3n\u016f korun, proto biologickou l\u00e9\u010dbu nedostanou v\u0161ichni pacienti, kte\u0159\u00ed by ji pot\u0159ebovali. D\u016fvodem vysok\u00fdch n\u00e1klad\u016f je zvy\u0161ov\u00e1n\u00ed \u00fahrad za biologickou l\u00e9\u010dbu a neust\u00e1l\u00e9 roz\u0161i\u0159ov\u00e1n\u00ed indikac\u00ed t\u00e9to l\u00e9\u010dby. To m\u00e1 za n\u00e1sledek, \u017ee biologickou l\u00e9\u010dbu pacient nedostane v &#8222;b\u011b\u017en\u00e9&#8220; ambulanci nebo nemocnici, ale pouze ve specializovan\u00fdch centrech. Jedn\u00edm z t\u011bchto center je CCBR, ve kter\u00e9m jsou pacient\u016fm provedena pot\u0159ebn\u00e1 vy\u0161et\u0159en\u00ed a je jim biologick\u00e1 l\u00e9\u010dba bezplatn\u011b nab\u00eddnuta a pod\u00e1v\u00e1na.<\/p>\n<p>&#8211; Kte\u0159\u00ed pacienti v\u00e1s mohou kontaktovat?<\/p>\n<p>Jsou to pacienti s lup\u00e9nkou, kte\u0159\u00ed maj\u00ed posti\u017een\u00fdch minim\u00e1ln\u011b deset procent t\u011bla. D\u00e1le lid\u00e9 s psoriatickou artritidou, B\u011bcht\u011brevovou chorobou, artr\u00f3zou kolen, ky\u010dl\u00ed nebo p\u00e1te\u0159e. Biologick\u00e1 l\u00e9\u010dba pom\u00e1h\u00e1 i p\u0159i ulcerozn\u00ed colitid\u011b, Crohnov\u011b chorob\u011b, d\u00e1le po infarktu myokardu, c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b, operaci kr\u010dn\u00edch tepen i po ischemick\u00e9 chorob\u011b doln\u00edch kon\u010detin.<\/p>\n<p>Pardubick\u00fd den\u00edk<br \/>\n<a href=\"http:\/\/pardubicky.denik.cz\/\">http:\/\/pardubicky.denik.cz\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Klinika pom\u00e1h\u00e1 pacient\u016fm s lup\u00e9nkou, s artr\u00f3zou kolen, ky\u010dl\u00ed, p\u00e1te\u0159e, ale i lidem po infarktu myokardu, \u010di c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b<\/p>\n<\/div>","protected":false},"author":1,"featured_media":14126,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-24894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/24894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24894"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/24894\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14126"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}