{"id":25023,"date":"2016-03-23T18:08:00","date_gmt":"2016-03-23T17:08:00","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=25023"},"modified":"2016-03-23T18:10:59","modified_gmt":"2016-03-23T17:10:59","slug":"studie-zrak-se-po-stredni-otrave-metanolem-umi-zregenerovat","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=25023","title":{"rendered":"Studie: Zrak se po st\u0159edn\u00ed otrav\u011b metanolem um\u00ed zregenerovat"},"content":{"rendered":"

Zrak se po m\u00edrn\u00e9 a st\u0159edn\u011b t\u011b\u017ek\u00e9 otrav\u011b metanolem dok\u00e1\u017ee zregenerovat. Zjistil to v\u00fdzkumn\u00fd t\u00fdm pod veden\u00edm Sergeje Zacharova z kliniky pracovn\u00edho l\u00e9ka\u0159stv\u00ed 1.l\u00e9ka\u0159sk\u00e9 fakulty UK a V\u0161eobecn\u00e9 fakultn\u00ed nemocnice (VFN).<\/strong><\/p>\n

<\/p>\n

T\u00fdm dlouhodob\u011b sleduje p\u011bt des\u00edtek lid\u00ed, kte\u0159\u00ed se otr\u00e1vili p\u0159i tzv. metanolov\u00e9 af\u00e9\u0159e v letech 2012 a 2013. V dob\u011b otravy m\u011bli v pr\u016fm\u011bru 46 let. O v\u00fdsledc\u00edch studie informoval Zacharov.<\/p>\n

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„Uk\u00e1zalo se, \u017ee se n\u00e1mi nam\u011b\u0159en\u00e9 parametry zrakov\u00fdch funkc\u00ed u v\u011bt\u0161iny pacient\u016f po roce a p\u016fl od otravy vr\u00e1tily k norm\u00e1ln\u00edm hodnot\u00e1m. Lid\u00e9 subjektivn\u011b poci\u0165ovali, \u017ee vid\u00ed l\u00e9pe ne\u017e kr\u00e1tce po propu\u0161t\u011bn\u00ed z nemocnice. U t\u011b\u017ece posti\u017een\u00fdch pacient\u016f, jich\u017e byla zhruba p\u011btina, jsme v\u0161ak \u017e\u00e1dn\u00e9 zlep\u0161en\u00ed zrakov\u00fdch funkc\u00ed nezaznamenali, naopak u n\u011bkter\u00fdch se zrak zhor\u0161il,“ uvedl.<\/p>\n

U t\u00e9m\u011b\u0159 poloviny pacient\u016f po\u0161kodila kyselina mraven\u010d\u00ed vznikaj\u00edc\u00ed v t\u011ble p\u0159i otrav\u011b metanolem i neurony v hlubok\u00fdch struktur\u00e1ch mozku. Z dlouhodob\u00e9ho hlediska to m\u016f\u017ee v\u00e9st k poklesu intelektu\u00e1ln\u00edch schopnost\u00ed, pam\u011bti a poru\u0161e jemn\u00e9 motoriky. Rychl\u00fd z\u00e1nik neuron\u016f je p\u0159\u00edzna\u010dn\u00fd pro Parkinsonovu a Alzheimerovu chorobu. V\u011bdci nyn\u00ed zkoumaj\u00ed, zda procesy obnovy a z\u00e1niku podobn\u00e9 t\u011bm, kter\u00e9 se d\u011bj\u00ed ve zrakov\u00e9m nervu v pr\u016fb\u011bhu let po otrav\u011b metanolem, jsou p\u0159\u00edtomny i v hlubok\u00fdch struktur\u00e1ch mozku.<\/p>\n

Metanol se \u010dasto vyskytuje v n\u00edzk\u00fdch koncentrac\u00edch v ovzdu\u0161\u00ed pracovi\u0161\u0165, v pr\u016fmyslu potravin\u00e1\u0159sk\u00e9m, chemick\u00e9m \u010di farmaceutick\u00e9m. Pou\u017e\u00edv\u00e1 se jako rozpou\u0161t\u011bdlo, sou\u010d\u00e1st barviv, nemrznouc\u00edch sm\u011bs\u00ed a pohonn\u00fdch hmot. Dlouhodob\u00e9 sledov\u00e1n\u00ed n\u00e1sledku akutn\u00ed otravy m\u016f\u017ee d\u00e1t odpov\u011b\u010f na ot\u00e1zku, zda vystaven\u00ed \u010dlov\u011bka p\u016fsoben\u00ed tohoto jedu, by\u0165 v mal\u00fdch koncentrac\u00edch, ale po del\u0161\u00ed dobu, m\u016f\u017ee m\u00edt vliv na vznik Parkinsonovy a Alzheimerovy choroby nebo po\u0161kozen\u00ed perifern\u00edch nerv\u016f.<\/p>\n

„Ve zkoum\u00e1n\u00ed neurodegenerativn\u00edch proces\u016f u pacient\u016f po akutn\u00ed otrav\u011b metanolem bude t\u00fdm pokra\u010dovat i v p\u0159\u00ed\u0161t\u00edch letech, proto\u017ee usp\u011bl ve ve\u0159ejn\u00e9 sout\u011b\u017ei o grant z ministerstva zdravotnictv\u00ed na roky 2016 a\u017e 2019,“ uvedl d\u011bkan 1. l\u00e9ka\u0159sk\u00e9 fakulty UK profesor Aleksi \u0160edo.<\/p>\n

Na studii se pod\u00edlej\u00ed tak\u00e9 l\u00e9ka\u0159i z klinik neurologick\u00e9, radiodiagnostick\u00e9, o\u010dn\u00ed a adiktologie VFN, v\u011bdci z Institutu klinick\u00e9 a experiment\u00e1ln\u00ed medic\u00edny a Vysok\u00e9 \u0161koly chemicko-technologick\u00e9.<\/p>\n

V obdob\u00ed hromadn\u00fdch otrav metanolem ze z\u00e1vadn\u00fdch alkoholick\u00fdch n\u00e1poj\u016f v letech 2012 a\u017e 2013 bylo ve zdravotnick\u00fdch za\u0159\u00edzen\u00edch v cel\u00e9 \u010cR hospitalizov\u00e1no p\u0159es 100 pacient\u016f po akutn\u00ed otrav\u011b, z nich zhruba 80 procent p\u0159e\u017eilo.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Zrak se po m\u00edrn\u00e9 a st\u0159edn\u011b t\u011b\u017ek\u00e9 otrav\u011b metanolem dok\u00e1\u017ee zregenerovat. Zjistil to v\u00fdzkumn\u00fd t\u00fdm pod veden\u00edm Sergeje Zacharova z kliniky pracovn\u00edho l\u00e9ka\u0159stv\u00ed 1.l\u00e9ka\u0159sk\u00e9 fakulty […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-25023","post","type-post","status-publish","format-standard","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/25023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25023"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/25023\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}