{"id":26605,"date":"2016-10-26T06:07:12","date_gmt":"2016-10-26T04:07:12","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=26605"},"modified":"2016-10-26T06:07:12","modified_gmt":"2016-10-26T04:07:12","slug":"krev-lekarum-rekne-zda-je-rakovina-pryc","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=26605","title":{"rendered":"Krev l\u00e9ka\u0159\u016fm \u0159ekne, zda je rakovina pry\u010d"},"content":{"rendered":"<p><strong>Tekut\u00e1 biopsie zvy\u0161uje \u0161ance p\u0159i n\u00e1dorech plic<\/strong><!--more--><\/p>\n<p>Pacienta s rakovinou plic, kter\u00fd podstoupil chemoterapii nebo operaci, \u010dek\u00e1 hned n\u011bkolik dal\u0161\u00edch nep\u0159\u00edjemn\u00fdch okam\u017eik\u016f.<br \/>\nAby l\u00e9ka\u0159i zjistili, jestli byla dosavadn\u00ed l\u00e9\u010dba \u00fa\u010dinn\u00e1, mus\u00ed mu odebrat \u010d\u00e1st posti\u017een\u00e9 tk\u00e1n\u011b. A nap\u0159\u00edklad v p\u0159\u00edpad\u011b rakoviny plic je tento odb\u011br velmi nep\u0159\u00edjemn\u00fd. Tk\u00e1\u0148 je h\u016f\u0159e dostupn\u00e1 a odeb\u00edr\u00e1 se z hrudi dutou jehlou. Pokud se v\u016fbec poda\u0159\u00ed pot\u0159ebn\u00e9 mno\u017estv\u00ed tk\u00e1n\u011b z\u00edskat, na v\u00fdsledky vy\u0161et\u0159en\u00ed se \u010dek\u00e1 t\u0159i a\u017e \u010dty\u0159i t\u00fddny.<br \/>\nV\u00fdzkumn\u00edci nyn\u00ed vyv\u00edjej\u00ed novou metodu, kter\u00e1 n\u00e1dorovou DNA dok\u00e1\u017ee odhalit z krve pacienta. Ozna\u010duj\u00ed ji jako tekutou biopsii. Dok\u00e1\u017ee p\u0159esn\u011bji identifikovat rozsah onemocn\u011bn\u00ed, nen\u00ed pro pacienta tak nep\u0159\u00edjemn\u00e1 a uspo\u0159\u00ed i \u010das, kter\u00fd je v p\u0159\u00edpad\u011b onkologick\u00fdch vy\u0161et\u0159en\u00ed tak d\u016fle\u017eit\u00fd. M\u00edsto n\u011bkolika t\u00fddn\u016f jsou v\u00fdsledky k dispozici ji\u017e za t\u0159i a\u017e p\u011bt dn\u016f.<br \/>\nOnkologov\u00e9 vkl\u00e1daj\u00ed do tekut\u00e9 bio- psie velk\u00e9 nad\u011bje. Hlavn\u00ed prosp\u011bch z t\u00e9to metody by m\u011bli nap\u0159\u00edklad pacienti, u nich\u017e je napaden\u00e1 tk\u00e1\u0148 obt\u00ed\u017en\u011b dostupn\u00e1. L\u00e9ka\u0159i by mohli d\u00edky n\u00ed tak\u00e9 l\u00e9pe sledovat stav pacient\u016f po operaci nebo b\u011bhem onkologick\u00e9 l\u00e9\u010dby. S novou metodou u\u017e maj\u00ed prvn\u00ed pozitivn\u00ed zku\u0161enosti. Nap\u0159\u00edklad na plicn\u00ed klinice ve Fakultn\u00ed nemocnici v Plzni tekutou biopsii vyzkou\u0161eli zhruba na dvaceti pacientech.<br \/>\nNad\u011bjn\u00e9 v\u00fdsledky hl\u00e1s\u00ed firmy, kter\u00e9 se sna\u017e\u00ed metodu tekut\u00e9 biopsie d\u00e1le vyv\u00edjet. V\u00fdzkumn\u00fd \u00fastav Genomac spolupracuje vedle uveden\u00e9 plicn\u00ed kliniky v Plzni tak\u00e9 s pra\u017eskou \u00fast\u0159edn\u00ed vojenskou nemocnic\u00ed a fakultn\u00edmi nemocnicemi v Praze Motole nebo Hradci Kr\u00e1lov\u00e9.<\/p>\n<p>Nov\u00e1 metoda odhal\u00ed v\u00edc<\/p>\n<p>P\u0159ed t\u0159emi t\u00fddny Genomac zve\u0159ejnil v\u00fdsledky sv\u00e9 studie \u00fa\u010dastn\u00edk\u016fm odborn\u00e9 konference na Florid\u011b.<br \/>\n&#8222;Sledovali jsme t\u00e9m\u011b\u0159 stovku pacient\u016f s pokro\u010dilou rakovinou kone\u010dn\u00edku a tlust\u00e9ho st\u0159eva, kter\u00fdm l\u00e9ka\u0159i p\u0159i operaci odstranili metast\u00e1zy v j\u00e1trech. Po dobu n\u011bkolika let jsme porovn\u00e1vali pravideln\u011b hladiny rakovinn\u00e9 DNA v krvi p\u0159ed a po operac\u00edch. Uk\u00e1zalo se, \u017ee hladiny rakovinn\u00e9 DNA v krvi odpov\u00eddaj\u00ed tomu, jak byla operace radik\u00e1ln\u00ed. Pokud l\u00e9ka\u0159i odstranili n\u00e1dor cel\u00fd, byly hladiny rakovinn\u00e9 DNA nulov\u00e9, zat\u00edmco kdy\u017e odebrali pouze \u010d\u00e1st n\u00e1doru, hladina byla v\u00fdrazn\u011b vy\u0161\u0161\u00ed. Testy z krve tak\u00e9 dok\u00e1zaly v\u010das odhalit n\u00e1vrat onemocn\u011bn\u00ed,&#8220; \u0159\u00edk\u00e1 Lucie Bene\u0161ov\u00e1 z v\u00fdzkumn\u00e9ho \u00fastavu. V zahrani\u010d\u00ed se v\u00fdvojem nov\u00e9 metody zab\u00fdv\u00e1 tak\u00e9 nap\u0159\u00edklad americk\u00e1 firma Biocept a konsorcium firem Merck a Sysmex.<\/p>\n<p>Zat\u00edm nen\u00ed stoprocentn\u011b \u00fasp\u011b\u0161n\u00e1<\/p>\n<p>Letos se nav\u00edc v\u00fdzkumn\u00edk\u016fm poda\u0159ilo dokon\u010dit n\u011bkolik slibn\u00fdch studi\u00ed. Na mezin\u00e1rodn\u00edm onkologick\u00e9m kongresu ASCO se l\u00e9ka\u0159i z kalifornsk\u00e9 univerzity pochlubili v\u00fdsledky rozs\u00e1hl\u00e9 studie na 15 tis\u00edc\u00edch onkologick\u00fdch pacientech. Porovn\u00e1vali spolehlivost test\u016f z krve a tk\u00e1n\u011b. Uk\u00e1zalo se, \u017ee tekut\u00e1 biopsie &#8222;na\u0161la&#8220; DNA rakovinn\u00fdch bun\u011bk v p\u0159\u00edpadech, kter\u00e9 pak potvrdily i odb\u011bry z tk\u00e1n\u011b. N\u011bkter\u00e9 dal\u0161\u00ed ale nezachytila.<br \/>\nStudie tak\u00e9 zdokumentovala, \u017ee u t\u00e9m\u011b\u0159 dvou t\u0159etin pacient\u016f s rakovinou plic se nepoda\u0159ilo odebrat dostate\u010dn\u00e9 mno\u017estv\u00ed tk\u00e1n\u011b pot\u0159ebn\u00e9 ke klasick\u00e9 biopsii a l\u00e9ka\u0159i tak nemohli ud\u011blat spolehlivou diagn\u00f3zu. A v t\u011bchto p\u0159\u00edpadech se uk\u00e1zala jako vhodn\u00e1 pr\u00e1v\u011b tekut\u00e1 biopsie.<br \/>\nNad\u011bji do t\u00e9to metody vkl\u00e1d\u00e1 i p\u0159edn\u00ed \u010desk\u00fd onkolog Lubo\u0161 Petru\u017eelka. P\u0159ed n\u011bkolika dny se vr\u00e1til z evropsk\u00e9ho onkologick\u00e9ho kongresu ESMO v Kodani, kde byla tekut\u00e1 biopsie velk\u00e9 t\u00e9ma. &#8222;Tato metoda m\u016f\u017ee nahradit opakovan\u00e9 odb\u011bry tk\u00e1n\u011b p\u0159i n\u00e1vratu n\u00e1dorov\u00e9ho onemocn\u011bn\u00ed a zbytky choroby po chirurgick\u00e9 l\u00e9\u010db\u011b.&#8220;<br \/>\nPon\u011bkud skepti\u010dt\u00ed jsou zat\u00edm k tekut\u00e9 biopsii n\u011bkte\u0159\u00ed patologov\u00e9. Novou metodu v\u00edtaj\u00ed, ale nev\u011b\u0159\u00ed, \u017ee by v dohledn\u00e9 dob\u011b mohla zcela nahradit klasick\u00fd odb\u011br tk\u00e1n\u011b. Tvrd\u00ed toti\u017e, \u017ee nen\u00ed tak spolehliv\u00e1. &#8222;Tekut\u00e1 biopsie se v sou\u010dasn\u00e9 dob\u011b m\u016f\u017ee uplatnit u n\u011bkter\u00fdch nemocn\u00fdch s rakovinou plic. Bohu\u017eel v\u0161ak vy\u0161et\u0159en\u00ed z krve nezachyt\u00ed a\u017e t\u0159etinu p\u0159\u00edpad\u016f. Pokud by tak v\u0161ichni nemocn\u00ed byli vy\u0161et\u0159eni pouze tekutou biopsi\u00ed bez odebr\u00e1n\u00ed vzorku tk\u00e1n\u011b, nemusela by se jim dostat pot\u0159ebn\u00e1 c\u00edlen\u00e1 l\u00e9\u010dba,&#8220; upozor\u0148uje patolog Ale\u0161 Ry\u0161ka.<\/p>\n<p>Fakta Jak funguje nov\u00e1 metoda zvan\u00e1 tekut\u00e1 biopsie * Jedinou rakovinotvornou bu\u0148ku najde mezi miliardami ostatn\u00edch zdrav\u00fdch. * Barvivo na speci\u00e1ln\u00edm mikro\u010dipu rakovinnou bu\u0148ku ozna\u010d\u00ed. * Vy\u0161et\u0159en\u00ed dok\u00e1\u017ee izolovat z krve cirkuluj\u00edc\u00ed n\u00e1dorovou DNA (ctDNA). * Pou\u017e\u00edt se d\u00e1 nej\u010dast\u011bji v p\u0159\u00edpad\u011b rakoviny plic, prsu, st\u0159ev a kone\u010dn\u00edku.<\/p>\n<p>Iva Bezd\u011bkov\u00e1, report\u00e9rka MF DNES<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Tekut\u00e1 biopsie zvy\u0161uje \u0161ance p\u0159i n\u00e1dorech plic<\/p>\n<\/div>","protected":false},"author":1,"featured_media":2344,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-26605","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/26605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26605"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/26605\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/2344"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}