{"id":27529,"date":"2017-03-14T11:24:17","date_gmt":"2017-03-14T10:24:17","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=27529"},"modified":"2017-03-14T11:24:17","modified_gmt":"2017-03-14T10:24:17","slug":"rozpad-osobnosti-cesti-vedci-dali-nadeji-tezce-nemocnym","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=27529","title":{"rendered":"Rozpad osobnosti. \u010ce\u0161t\u00ed v\u011bdci dali nad\u011bji t\u011b\u017ece nemocn\u00fdm"},"content":{"rendered":"

Za\u010dalo to zcela nen\u00e1padn\u011b: oby\u010dejn\u00fdm zapom\u00edn\u00e1n\u00edm. Postupn\u011b se ale nemoc rozvinula do ob\u0159\u00edch rozm\u011br\u016f. Pavl\u00edna Vestf\u00e1lov\u00e1 propadala \u00fazkostem a depres\u00edm. P\u0159id\u00e1valy se poruchy \u0159e\u010di, probl\u00e9my s polyk\u00e1n\u00edm a nezvladateln\u00e9 svalov\u00e9 tiky.<\/strong> <\/p>\n

Nakonec ani nevstala z postele. T\u0159icetilet\u00e1 pacientka skon\u010dila s rozkladem osobnosti a demenc\u00ed v invalidn\u00edm d\u016fchodu. Je odk\u00e1zan\u00e1 na pomoc okol\u00ed. Huntingtonova choroba j\u00ed zcela zni\u010dila \u017eivot.<\/p>\n

Nyn\u00ed m\u00e1 ale tis\u00edcovka \u010desk\u00fdch pacient\u016f, kte\u0159\u00ed touto nemoc\u00ed trp\u00ed, nad\u011bji na vyl\u00e9\u010den\u00ed. \u010ce\u0161t\u00ed v\u011bdci toti\u017e usp\u011bli s preklinickou studi\u00ed, b\u011bhem kter\u00e9 zkoumali na prasatech \u00fa\u010dinky adenoviru. P\u0159\u00ed\u0161t\u00ed rok by se podle nich mohla metoda za\u010d\u00edt zkou\u0161et na lidech. V r\u00e1mci T\u00fddne mozku to v\u010dera \u0159ekla \u010dlenka v\u011bdeck\u00e9ho t\u00fdmu Zdenka Ellederov\u00e1.<\/p>\n

„M\u00e1me za sebou \u00fasp\u011b\u0161nou studii, kterou jsme prov\u00e1d\u011bli u\u017e na \u010dtvrt\u00e9 generaci miniaturn\u00edch prasat,“ popsala pr\u00e1ci v\u011bdc\u016f z Lib\u011bchova na M\u011blnicku Zdenka Ellederov\u00e1.<\/p>\n

Prasata jsou podle n\u00ed speci\u00e1ln\u011b upraven\u00e1. „Vytvo\u0159ili jsme modely, kter\u00e9 by m\u011bly co nejv\u00edce p\u0159ipom\u00ednat lidsk\u00fd organismus \u2013 v\u00e1hou i velikost\u00ed org\u00e1n\u016f jsou podobn\u00e1 \u010dlov\u011bku,“ dopl\u0148uje. V\u011bdci je nav\u00edc vybavili zmutovan\u00fdm lidsk\u00fdm genem, kter\u00fd nespr\u00e1vn\u011b k\u00f3duje tvarovan\u00fd protein zvan\u00fd huntingtin \u2013 to znamen\u00e1 l\u00e1tku, kter\u00e1 se vznikem smrteln\u00e9 choroby souvis\u00ed.<\/p>\n

JEDIN\u00cd NA SV\u011aT\u011a<\/p>\n

„Do nervov\u00fdch bun\u011bk t\u011bchto zv\u00ed\u0159ec\u00edch model\u016f jsme vpravili adenovirus, kter\u00fd zp\u016fsob\u00ed, \u017ee se tvorba zmutovan\u00e9ho huntingtinu utlum\u00ed. N\u011bkdy se dokonce zcela zastav\u00ed,“ pokou\u0161\u00ed se jednodu\u0161e vysv\u011btlit v\u00fdzkum biolo\u017eka. \u00dasp\u011b\u0161nost podle n\u00ed byla stoprocentn\u00ed. Genov\u00e1 terapie zabrala u v\u0161ech prasat. P\u0159\u00ed\u0161t\u00ed rok se proto v\u00fdzkum p\u0159esouv\u00e1 ze st\u00e1j\u00ed v Lib\u011bchov\u011b do opera\u010dn\u00edch s\u00e1l\u016f v Brn\u011b. Tam u\u017e na n\u011bm budou krom\u011b veterin\u00e1\u0159\u016f spolupracovat tak\u00e9 lid\u0161t\u00ed neurochirurgov\u00e9 \u2013 budou se u\u010dit, jak terapii v mozku co nejp\u0159esn\u011bji zac\u00edlit.<\/p>\n

\u010ce\u0161t\u00ed v\u011bdci z lib\u011bchovick\u00e9ho Centra Pigmod jsou jedin\u00ed na sv\u011bt\u011b, komu se jedine\u010dn\u00fd model z\u00e1va\u017en\u00e9ho onemocn\u011bn\u00ed poda\u0159ilo sestavit. Dal\u0161\u00ed v\u00fdzkum \u2013 ov\u0161em na ovc\u00edch \u2013 prob\u00edh\u00e1 v Austr\u00e1lii.<\/p>\n

N\u00e1ro\u010dn\u00fd v\u00fdzkum finan\u010dn\u011b podpo\u0159ila americk\u00e1 nadace CHDI Foundation.<\/p>\n

Huntingtonovu chorobu poprv\u00e9 popsal v roce 1872 americk\u00fd l\u00e9ka\u0159 George Huntington. Jedn\u00e1 se o v\u00e1\u017en\u00e9 d\u011bdi\u010dn\u00e9 onemocn\u011bn\u00ed, kter\u00fdm trp\u00ed \u010dty\u0159i a\u017e deset lid\u00ed ze 100 tis\u00edc obyvatel. Propuk\u00e1 nej\u010dast\u011bji ve st\u0159edn\u00edm v\u011bku, tedy mezi t\u0159ic\u00e1t\u00fdm a \u010dty\u0159ic\u00e1t\u00fdm rokem. Mezi nejv\u00fdrazn\u011bj\u0161\u00ed p\u0159\u00edznaky pat\u0159\u00ed poruchy pozornosti, zapom\u00edn\u00e1n\u00ed, nekontrolovateln\u00e9 pohyby, zm\u011bny osobnosti a demence. Choroba trv\u00e1 obvykle kolem deseti let a kon\u010d\u00ed smrt\u00ed.<\/p>\n

VERONIKA RODRIGUEZ
\nPra\u017esk\u00fd den\u00edk
\nhttp:\/\/www.prazsky.denik.cz\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Za\u010dalo to zcela nen\u00e1padn\u011b: oby\u010dejn\u00fdm zapom\u00edn\u00e1n\u00edm. Postupn\u011b se ale nemoc rozvinula do ob\u0159\u00edch rozm\u011br\u016f. Pavl\u00edna Vestf\u00e1lov\u00e1 propadala \u00fazkostem a depres\u00edm. P\u0159id\u00e1valy se poruchy \u0159e\u010di, probl\u00e9my […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-27529","post","type-post","status-publish","format-standard","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/27529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27529"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/27529\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}