M\u016f\u017ee b\u00fdt p\u016fst cestou, jak p\u0159ekonat cukrovku? Snad ano, pokud se potvrd\u00ed v\u00fdsledky pokus\u016f na my\u0161\u00edch a na lidsk\u00fdch bu\u0148k\u00e1ch. Z dosavadn\u00edch poznatk\u016f se toti\u017e zd\u00e1, \u017ee \u010d\u00e1ste\u010dn\u00fd p\u016fst je schopen „opravit“ bu\u0148ky slinivky b\u0159i\u0161n\u00ed, kter\u00e9 produkuj\u00ed inzulin. Tyto bu\u0148ky jsou tak z\u0159ejm\u011b „p\u0159eprogramov\u00e1ny“, tak\u017ee jsou schopny znovu vyr\u00e1b\u011bt dostate\u010dn\u00e9 mno\u017estv\u00ed hormonu.<\/p>\n
V\u00fd\u017eiva, kterou dost\u00e1valy pokusn\u00e9 my\u0161i, je \u010d\u00e1ste\u010dn\u00fd p\u016fst. Vypracoval jej Valter Longo z mil\u00e1nsk\u00e9ho Institutu molekul\u00e1rn\u00ed onkologie FIRC, dnes v \u010dele Institutu dlouhov\u011bkosti p\u0159i Jihokalifornsk\u00e9 univerzit\u011b. Navr\u017een\u00e1 dieta m\u011bla b\u00fdt p\u016fvodn\u011b metodou k omezen\u00ed stresu a k ochran\u011b bun\u011bk p\u0159i chemoterapii. Spo\u010d\u00edv\u00e1 v tom, \u017ee se p\u011bt dn\u00ed konzumuje strava s n\u00edzk\u00fdm obsahem tuk\u016f a cukr\u016f a pot\u00e9 n\u00e1sleduje n\u00e1vrat k norm\u00e1ln\u00ed v\u00fd\u017eiv\u011b.<\/p>\n
Dosavadn\u00ed studie ukazuj\u00ed, \u017ee na fyziologick\u00e9 \u00farovni tento typ diety jakoby napodobuje \u00fa\u010dinky mnohem p\u0159\u00edsn\u011bj\u0161\u00edho p\u016fstu a p\u0159edev\u0161\u00edm funguje jako jak\u00e9si o\u017eiven\u00ed organismu, b\u011bhem n\u011bho\u017e jsou produkov\u00e1ny nov\u00e9 bu\u0148ky a zpomaluje se st\u00e1rnut\u00ed d\u00edky redukci p\u016fsoben\u00ed t\u0159\u00ed kl\u00ed\u010dov\u00fdch gen\u016f, a sice IGF-1, TOR a PKA. Drastick\u00fd pokles t\u011bchto gen\u016f vrac\u00ed podle Longa bu\u0148ky do jak\u00fdchsi embryon\u00e1ln\u00edch podm\u00ednek.<\/p>\n
„Bu\u0148ky upadaj\u00ed b\u011bhem p\u016fstu do jak\u00e9hosi sp\u00e1nku a pak, kdy\u017e za\u010dneme j\u00edst norm\u00e1ln\u011b, mohou vytvo\u0159it mnoh\u00e9 rozmanit\u00e9 bun\u011b\u010dn\u00e9 typologie, mezi nimi i beta bu\u0148ky, tedy ty bu\u0148ky ve slinivce b\u0159i\u0161n\u00ed, kter\u00e9 produkuj\u00ed inzulin,“ cituje Longa italsk\u00fd den\u00edk Corriere della Sera.<\/p>\n
Longo pou\u017eil ke studiu \u00fa\u010dink\u016f sv\u00e9 diety dva r\u016fzn\u00e9 modely cukrovky: v jednom p\u0159\u00edpad\u011b m\u011bly my\u0161i genetickou mutaci, kter\u00e1 vyvol\u00e1v\u00e1 rezistenci v\u016f\u010di inzulinu a ztr\u00e1tu sekrece tohoto hormonu (tedy model pro cukrovku 2. typu), ve druh\u00e9m p\u0159\u00edpad\u011b byly my\u0161i l\u00e9\u010deny chemickou l\u00e1tkou, kter\u00e1 zab\u00edj\u00ed beta bu\u0148ky (model pro cukrovku 1. typu). Ob\u011bma skupin\u00e1m byla pod\u00e1v\u00e1na dieta ve t\u0159ech cyklech. V\u00fdsledky byly vynikaj\u00edc\u00ed: u obou model\u016f se diferencovaly nov\u00e9 bu\u0148ky schopn\u00e9 produkovat inzulin a zaru\u010dit spr\u00e1vnou rovnov\u00e1hu glykemie.<\/p>\n
V\u00fdsledky se potvrdily tak\u00e9 u pokus\u016f na bu\u0148k\u00e1ch slinivky b\u0159i\u0161n\u00ed zdrav\u00fdch lid\u00ed a lid\u00ed s cukrovkou 1. typu. Jestli\u017ee byly podrobeny diet\u011b, produkce inzulinu v t\u011bchto bu\u0148k\u00e1ch byla \u00fa\u010dinn\u011b stimulov\u00e1na. „To na jedn\u00e9 stran\u011b ukazuje, jak je mo\u017eno p\u0159eprogramovat bu\u0148ky jen pomoc\u00ed diety, beze zm\u011bny genomu, na druh\u00e9 stran\u011b to ukazuje potenci\u00e1l v\u00fd\u017eivy k omezen\u00ed p\u0159\u00edznak\u016f cukrovky,“ uvedl Longo. „V\u00fdznam diety v\u0161ak p\u0159esahuje tuto chorobu: \u00fa\u010dinky \u0159\u00edzen\u00e9ho p\u016fstu se studuj\u00ed i na dal\u0161\u00edch bun\u011b\u010dn\u00fdch syst\u00e9mech. Tento mechanismus m\u016f\u017ee b\u00fdt zp\u016fsobem, jak zlep\u0161it zdravotn\u00ed stav,“ dodal.<\/p>\n
Longo v \u00fanoru publikoval na str\u00e1nk\u00e1ch magaz\u00ednu Science Translational Medicine studii na dobrovoln\u00edc\u00edch, v n\u00ed\u017e uk\u00e1zal, \u017ee t\u0159i cykly jeho diety sni\u017euj\u00ed nebezpe\u010d\u00ed vzniku nejen cukrovky, ale i rakoviny a kardiovaskul\u00e1rn\u00edch chorob t\u00edm, \u017ee sni\u017euj\u00ed \u00farove\u0148 IGF-1 a glyk\u00e9mie. Krom\u011b toho pozitivn\u011b p\u016fsob\u00ed na parametry jako je v\u00e1ha, cholesterol \u010di triglyceridy.<\/p>\n","protected":false},"excerpt":{"rendered":"
M\u016f\u017ee b\u00fdt p\u016fst cestou, jak p\u0159ekonat cukrovku? Snad ano, pokud se potvrd\u00ed v\u00fdsledky pokus\u016f na my\u0161\u00edch a na lidsk\u00fdch bu\u0148k\u00e1ch. Z dosavadn\u00edch poznatk\u016f se toti\u017e […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":19374,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-27643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/27643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27643"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/27643\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/19374"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}