{"id":29739,"date":"2017-12-07T11:47:24","date_gmt":"2017-12-07T10:47:24","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=29739"},"modified":"2017-12-07T11:47:24","modified_gmt":"2017-12-07T10:47:24","slug":"vedci-objevili-v-leku-pro-alkoholiky-protinadorove-ucinky","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=29739","title":{"rendered":"V\u011bdci objevili v l\u00e9ku pro alkoholiky protin\u00e1dorov\u00e9 \u00fa\u010dinky"},"content":{"rendered":"<p><strong>V\u011bdc\u016fm z mezin\u00e1rodn\u00edho t\u00fdmu, ve kter\u00e9m byli zapojeni tak\u00e9 badatel\u00e9 z Olomouce, se poda\u0159ilo objevit v l\u00e9ku proti alkoholov\u00e9 z\u00e1vislosti mimo\u0159\u00e1dn\u00e9 protin\u00e1dorov\u00e9 \u00fa\u010dinky. <\/strong><!--more--><\/p>\n<p>Disulfiram, zn\u00e1m\u00fd pod komer\u010dn\u00edm n\u00e1zvem Antabus, by tak bylo mo\u017en\u00e9 v budoucnu vyu\u017e\u00edt v boji proti rakovin\u011b. Studii t\u00fdmu veden\u00e9ho v\u011bdci z \u00dastavu molekul\u00e1rn\u00ed a transla\u010dn\u00ed medic\u00edny (\u00daMTM) L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Palack\u00e9ho v Olomouci zve\u0159ejnil jeden z nejpresti\u017en\u011bj\u0161\u00edch v\u011bdeck\u00fdch \u010dasopis\u016f Nature. \u010cTK o tom informovali z\u00e1stupci univerzity.<\/p>\n<p>Nakolik bude mo\u017en\u00e9 objev skute\u010dn\u011b vyu\u017e\u00edt pro zaveden\u00ed nov\u00e9 l\u00e9\u010dby rakoviny, uk\u00e1\u017eou klinick\u00e9 studie.<\/p>\n<p>Na v\u00fdzkumu se pod\u00edleli \u010de\u0161t\u00ed v\u011bdci v \u010dele s Ji\u0159\u00edm B\u00e1rtkem a dal\u0161\u00ed badatel\u00e9 z D\u00e1nska, \u0160v\u00e9dska, \u0160v\u00fdcarska, USA a Kanady. &#8222;Pr\u00e1ce vych\u00e1z\u00ed z epidemiologick\u00e9 studie proveden\u00e9 na d\u00e1nsk\u00fdch pacientech &#8211; alkoholic\u00edch, u nich\u017e bylo zji\u0161t\u011bno malign\u00ed onemocn\u011bn\u00ed. Uk\u00e1zalo se, \u017ee pacienti, kte\u0159\u00ed i po n\u00e1dorov\u00e9 diagn\u00f3ze nad\u00e1le u\u017e\u00edvali disulfiram, m\u011bli v\u00fdrazn\u011b men\u0161\u00ed riziko \u00famrt\u00ed ne\u017e pacienti, kte\u0159\u00ed s u\u017e\u00edv\u00e1n\u00edm p\u0159estali,&#8220; uvedli z\u00e1stupci univerzity.<\/p>\n<p>T\u0159i des\u00edtky v\u011bdc\u016f, kte\u0159\u00ed jsou pod studi\u00ed podepsan\u00ed, b\u011bhem v\u00fdzkumu protin\u00e1dorov\u00e9ho efektu disulfiramu zjistili, \u017ee l\u00e9k je v lidsk\u00e9m t\u011ble za p\u0159isp\u011bn\u00ed m\u011bdi metabolizov\u00e1n na jinou l\u00e1tku, kter\u00e1 se hromad\u00ed v n\u00e1dorov\u00fdch bu\u0148k\u00e1ch a v nich se v\u00e1\u017ee na NPL4 protein. T\u00edm zp\u016fsobuje jeho imobilizaci a ztr\u00e1tu funk\u010dnosti, uvedli v\u011bdci. V\u00fdzkum aktivn\u00edho metabolitu l\u00e9ku disulfiram ozna\u010duj\u00ed za pr\u016flomov\u00e9 zji\u0161t\u011bn\u00ed.<\/p>\n<p>V b\u00e1d\u00e1n\u00ed odborn\u00edci z \u00daMTM a Fakultn\u00ed nemocnice Olomouc pokra\u010duj\u00ed a \u00fa\u010dinky disulfiramu v kombinaci s m\u011bd\u00ed ov\u011b\u0159uj\u00ed v klinick\u00e9 studii, kter\u00e1 je otev\u0159ena pro pacientky s metastatick\u00fdm karcinomem prsu.<\/p>\n<p>Disulfiram je l\u00e9k pou\u017e\u00edvan\u00fd v l\u00e9\u010db\u011b z\u00e1vislosti na alkoholu. P\u0159i l\u00e9\u010db\u011b alkoholismu je vyu\u017e\u00edv\u00e1n ji\u017e des\u00edtky let. P\u016fvodn\u011b byl pou\u017e\u00edv\u00e1n v l\u00e9\u010db\u011b st\u0159evn\u00edch infekc\u00ed. L\u00e9k m\u016f\u017ee fungovat jako u\u017eite\u010dn\u00e1 pom\u016fcka u lid\u00ed, kte\u0159\u00ed se rozhodnou p\u0159estat p\u00edt alkohol, ale pot\u0159ebuj\u00ed z\u00edskat pojistku, kter\u00e1 jim umo\u017en\u00ed plnou abstinenci od alkoholu dodr\u017eet.<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>V\u011bdc\u016fm z mezin\u00e1rodn\u00edho t\u00fdmu, ve kter\u00e9m byli zapojeni tak\u00e9 badatel\u00e9 z Olomouce, se poda\u0159ilo objevit v l\u00e9ku proti alkoholov\u00e9 z\u00e1vislosti mimo\u0159\u00e1dn\u00e9 protin\u00e1dorov\u00e9 \u00fa\u010dinky.<\/p>\n<\/div>","protected":false},"author":1,"featured_media":14127,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-29739","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/29739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29739"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/29739\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14127"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}