{"id":3110,"date":"2013-03-26T10:11:22","date_gmt":"2013-03-26T09:11:22","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=3110"},"modified":"2013-03-26T23:00:54","modified_gmt":"2013-03-26T22:00:54","slug":"genova-terapie-vylecila-pacienty-s-leukemii","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=3110","title":{"rendered":"Genov\u00e1 terapie vyl\u00e9\u010dila pacienty s leuk\u00e9mi\u00ed"},"content":{"rendered":"

Ameri\u010dt\u00ed v\u011bdci zdokonalili genovou terapii u smrteln\u00e9 kon\u010d\u00edc\u00ed akutn\u00ed leuk\u00e9mie natolik, \u017ee podstatn\u011b zvy\u0161uje jejich \u0161ance na vyl\u00e9\u010den\u00ed a z\u00e1chranu \u017eivota. Metodu studuj\u00ed tak\u00e9 \u010de\u0161t\u00ed l\u00e9ka\u0159i.<\/strong> <\/p>\n

Podle listu Science Translational Medicine se poda\u0159ilo p\u011bt pacient\u016f trp\u00edc\u00edch akutn\u00ed lymfoblastivkou leuk\u00e9mi\u00ed zcela vyl\u00e9\u010dit genetickou \u00fapravou bun\u011bk z jejich imunitn\u00edho syst\u00e9mu tak, aby napadly leukemick\u00e9 bu\u0148ky a zni\u010dily je.<\/p>\n

Tato akutn\u00ed forma leuk\u00e9mie rychle sp\u011bje ke smrti pacienta. Mnoz\u00ed um\u00edraj\u00ed d\u0159\u00edve, ne\u017e se do\u010dkaj\u00ed vhodn\u00e9ho d\u00e1rce k transplantaci kostn\u00ed d\u0159en\u011b, je\u017e by je mohla rakoviny zbavit.<\/p>\n

Na v\u011bdce siln\u011b zap\u016fsobilo, \u017ee se toto t\u011b\u017ek\u00e9 onemocn\u011bn\u00ed poda\u0159ilo vym\u00fdtit u v\u0161ech p\u011bti pacient\u016f. U jednoho zmizela rakovina za pouh\u00fdch osm dn\u00ed l\u00e9\u010dby.<\/p>\n

„V\u00fdsledky jsou pr\u016flomov\u00e9,“ \u0159ekl hlavn\u00ed autor studie, onkolog Renier Brentjens z Memorial Sloan-Kettering Cancer Center.<\/p>\n

L\u00e9ka\u0159i nasadili genovou terapii u p\u011bti vybran\u00fdch pacient\u016f ve v\u011bku od 23 do 66 let, u kter\u00fdch nepomohla standardn\u00ed chemoterapie a kte\u0159\u00ed dosud nenalezli d\u00e1rce pro transplantaci kostn\u00ed d\u0159en\u011b.<\/p>\n

P\u0159i leuk\u00e9mii se imunitn\u00ed syst\u00e9m st\u00e1v\u00e1 v\u016f\u010di leukemick\u00fdm bu\u0148k\u00e1m nete\u010dn\u00fd a nelikviduje je. V\u011bdci izolovali T-lymfocyty z t\u011bla nemocn\u00e9ho a vpravili do nich geneticky upraven\u00fd faktor,\u00a0 aby byly schopny rozeznat bu\u0148ky leukemick\u00e9 a napadnout je.<\/p>\n

L\u00e9ka\u0159i v\u0161ak nem\u011bli mo\u017enost posoudit, zda genov\u00e1 terapie vyl\u00e9\u010dila pacienty natrvalo. U \u010dty\u0159 z nich toti\u017e po \u00fasp\u011b\u0161n\u00e9 l\u00e9\u010db\u011b genovou terapi\u00ed provedli transplantaci kostn\u00ed d\u0159en\u011b, u jednoho z nich do\u0161lo po \u010dtvrt roce k n\u00e1vratu rakoviny a zem\u0159el.<\/p>\n

Metodu zkoumaj\u00ed tak\u00e9 \u010de\u0161t\u00ed v\u011bdci<\/strong><\/p>\n

„Jedn\u00e1 se o pozoruhodn\u00fd v\u00fdsledek a je mo\u017en\u00e9, \u017ee by to mohlo v budoucnosti i nahradit transplantaci. To v\u0161ak zat\u00edm nikdo \u0159\u00edci nem\u016f\u017ee,“ \u0159ekl p\u0159ednosta pra\u017esk\u00e9ho \u00dastavu hematologie a krevn\u00ed transf\u00faze Marek Trn\u011bn\u00fd.<\/p>\n

Tak\u00e9 p\u0159edn\u00ed \u010desk\u00fd hematoonkolog profesor Pavel Klener soud\u00ed, \u017ee jde o jednu z cest, jak p\u0159isp\u011bt k \u00fa\u010dinn\u00e9 l\u00e9\u010db\u011b leuk\u00e9mie. Ne\u017e se ale \u00fa\u010dinnost potvrd\u00ed a ne\u017e se metoda dostane do b\u011b\u017en\u00e9 praxe, m\u016f\u017ee je\u0161t\u011b uplynout n\u011bkolik let, p\u0159ipomn\u011bl Klener.<\/p>\n

invArena<\/p>\n

MUDr. Jan \u010cin\u010dura<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Ameri\u010dt\u00ed v\u011bdci zdokonalili genovou terapii u smrteln\u00e9 kon\u010d\u00edc\u00ed akutn\u00ed leuk\u00e9mie natolik, \u017ee podstatn\u011b zvy\u0161uje jejich \u0161ance na vyl\u00e9\u010den\u00ed a z\u00e1chranu \u017eivota. Metodu studuj\u00ed tak\u00e9 \u010de\u0161t\u00ed […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-3110","post","type-post","status-publish","format-standard","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/3110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3110"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/3110\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}