\u010ce\u0161t\u00ed hematologov\u00e9 ve spolupr\u00e1ci se zahrani\u010dn\u00edmi kolegy letos zahajuj\u00ed studii\u00a0 l\u00e9\u010dby d\u011bt\u00ed s akutn\u00ed leukemi\u00ed. Do n\u011bkolikalet\u00e9 studie nov\u00fdch mo\u017enost\u00ed l\u00e9\u010dby p\u0159ijmou p\u0159ibli\u017en\u011b 1500 d\u011bt\u00ed. <\/b><\/p>\n
Je to v\u016fbec poprv\u00e9, co takov\u00e1 studie vznikne, a odborn\u00edci \u010dekaj\u00ed, \u017ee jej\u00ed v\u00fdsledky ovlivn\u00ed budoucnost l\u00e9\u010dby nej\u010dast\u011bj\u0161\u00ed formy d\u011btsk\u00e9 leukemie.\u00a0<\/b><\/p>\n
\u010ce\u0161t\u00ed experti na d\u011btskou hemato-onkologii se do studie pou\u0161t\u00ed s kolegy z N\u011bmecka, Rakouska, \u0160v\u00fdcarska, It\u00e1lie, Izraele, Austr\u00e1lie a Slovenska. V \u010cesk\u00e9 republice si verdikt akutn\u00ed lymfoblastick\u00e9 leukemie ro\u010dn\u011b vyslechnou rodi\u010de asi 80 d\u011bt\u00ed, nej\u010dast\u011bji ve v\u011bku mezi 2\u00a0a\u00a05\u00a0lety. Nemoc se ohla\u0161uje \u00fanavou, bolest\u00ed kloub\u016f, kon\u010detin, hore\u010dkami, kter\u00e9 nereaguj\u00ed na l\u00e9ky.<\/p>\n
\u201eN\u00e1stup je rychl\u00fd, a pokud se okam\u017eit\u011b neza\u010dne s l\u00e9\u010dbou, vede to z\u00e1hy ke smrti d\u00edt\u011bte na krv\u00e1cen\u00ed, infekci, multiorg\u00e1nov\u00e9 selh\u00e1n\u00ed. D\u00edky modern\u00edm l\u00e9k\u016fm se v sou\u010dasn\u00e9 dob\u011b na\u0161t\u011bst\u00ed da\u0159\u00ed vyl\u00e9\u010dit 90 % v\u0161ech d\u011bt\u00ed s leukemi\u00ed. Jen u n\u011bkter\u00fdch vz\u00e1cn\u011bj\u0161\u00edch typ\u016f t\u00e9to nemoci je \u00fasp\u011b\u0161nost ni\u017e\u0161\u00ed. V posledn\u00edch 5 letech pokro\u010dila medic\u00edna natolik, \u017ee jsme schopni vyl\u00e9\u010dit ty d\u011bti, kter\u00e9 bychom d\u0159\u00edve ztratili,\u201c<\/i> \u0159\u00edk\u00e1 prof. MUDr. Jan Star\u00fd, DrSc., z Kliniky d\u011btsk\u00e9 hematologie a onkologie 2. LF UK a FN Motol v Praze.<\/p>\n
Pro srovn\u00e1n\u00ed, po\u010d\u00e1tkem 70. let 20. stolet\u00ed se da\u0159ilo vyl\u00e9\u010dit jednu t\u0159etinu d\u011bt\u00ed, v 80. letech dv\u011b t\u0159etiny. Pokrok v medic\u00edn\u011b umo\u017e\u0148uje hematoonkolog\u016fm \u010d\u00edm d\u00e1l p\u0159esn\u011bji zkoumat n\u00e1dor a p\u0159esn\u011b upravovat l\u00e9ky a l\u00e9\u010dbu podle toho, jak reaguje a jak se vyv\u00edj\u00ed.<\/p>\n
\u201eL\u00e9\u010dba leukemie trv\u00e1 v\u017edy 2 roky, ale pro n\u00e1s jsou nejd\u016fle\u017eit\u011bj\u0161\u00ed prvn\u00ed dny a t\u00fddny, kdy za pomoci molekul\u00e1rn\u00ed genetiky zkoum\u00e1me, jak rakovina na l\u00e9\u010dbu reaguje, kolik leukemick\u00fdch bun\u011bk je mezi zdrav\u00fdmi. Citlivost t\u00e9to metody je obrovsk\u00e1, um\u00ed odhalit jednu leukemickou bu\u0148ku mezi statis\u00edci norm\u00e1ln\u00edmi. \u010c\u00edm rychleji tyto n\u00e1dorov\u00e9 bu\u0148ky v pr\u016fb\u011bhu t\u00fddn\u016f miz\u00ed, t\u00edm lep\u0161\u00ed je progn\u00f3za pacienta. Tam, kde hned zpo\u010d\u00e1tku vid\u00edme, \u017ee leukemick\u00e9 bu\u0148ky reaguj\u00ed pomaleji, rovnou zvy\u0161ujeme intenzitu l\u00e9\u010dby nebo pl\u00e1nujeme transplantaci kostn\u00ed d\u0159en\u011b,\u201c<\/i> vysv\u011btluje prof. Star\u00fd.<\/p>\n
Dan\u00ed za zachra\u0148uj\u00edc\u00ed l\u00e9\u010dbu je vysok\u00fd v\u00fdskyt akutn\u00edch i pozdn\u00edch n\u00e1sledk\u016f l\u00e9\u010dby. Podle posledn\u00edch studi\u00ed 10\u201315 % d\u011bt\u00ed prod\u011bl\u00e1 p\u0159i l\u00e9\u010db\u011b \u017eivot ohro\u017euj\u00edc\u00ed a 50 % z\u00e1va\u017en\u00e9 komplikace l\u00e9\u010dby. Podle prof. Star\u00e9ho tak p\u0159ed hematoonkology stoj\u00ed v\u00fdzva, jak sn\u00ed\u017eit toxicitu l\u00e9\u010dby p\u0159i zachov\u00e1n\u00ed jej\u00ed \u00fa\u010dinnosti.<\/p>\n
Nad\u011bj\u00ed do budoucna je zapojen\u00ed vlastn\u00ed imunity<\/strong> \u010dlov\u011bka \u2013 imunoterapie. Jedn\u00e1 s o protil\u00e1tky aktivuj\u00edc\u00ed b\u00edl\u00e9 krvinky, kter\u00e9 za\u010dnou likvidovat n\u00e1dorov\u00e9 bu\u0148ky. Dal\u0161\u00ed nad\u011bj\u00ed jsou genov\u011b upraven\u00e9 b\u00edl\u00e9 krvinky, kter\u00e9 po vr\u00e1cen\u00ed zp\u011bt do krevn\u00edho ob\u011bhu ni\u010d\u00ed ty n\u00e1dorov\u00e9.<\/p>\n \u201eJe t\u0159eba p\u0159ipomenout, \u017ee naprost\u00e1 v\u011bt\u0161ina vyl\u00e9\u010den\u00fdch d\u011bt\u00ed, u nich\u017e se nemoc nevr\u00e1tila, \u017eije norm\u00e1ln\u00ed \u017eivot, pracuje, zakl\u00e1d\u00e1 vlastn\u00ed rodiny a rod\u00ed zdrav\u00e9 potomky,\u201c<\/i> dopl\u0148uje prof. Star\u00fd. V sou\u010dasnosti se l\u00e9\u010dba d\u011bt\u00ed s leukemi\u00ed soust\u0159ed\u00ed do 8 center v \u010cesk\u00e9 republice. D\u00edky pokroku v medic\u00edn\u011b l\u00e9ka\u0159i um\u00ed rozpoznat a\u017e 20 r\u016fzn\u00fdch podtyp\u016f nemoci a uplatnit \u201ena m\u00edru \u0161itou\u201c l\u00e9\u010dbu.<\/p>\n Takzvan\u00e1 precizn\u00ed medic\u00edna, kdy se l\u00e9ka\u0159i soust\u0159ed\u00ed na dokonalou diagnostiku, pozn\u00e1n\u00ed typu n\u00e1doru a jeho chov\u00e1n\u00ed, je hlavn\u00edm trendem hematoonkologie i medic\u00edny v\u016fbec. \u201eAbychom mohli zah\u00e1jit modern\u00ed, \u00fa\u010dinnou, ale tak\u00e9 velmi n\u00e1kladnou l\u00e9\u010dbu, kter\u00e1 u jedince dosahuje a\u017e statis\u00edc\u016f korun m\u011bs\u00ed\u010dn\u011b, mus\u00edme ur\u010dit p\u0159esnou diagn\u00f3zu nemocn\u00e9ho. Tedy nejenom perfektn\u011b zn\u00e1t jeho typ onemocn\u011bn\u00ed, ale i aktu\u00e1ln\u00ed stav jeho organismu, p\u0159idru\u017een\u00e9 choroby, dal\u0161\u00ed l\u00e9ky, kter\u00e9 u\u017e\u00edv\u00e1, jeho soci\u00e1ln\u00ed stav a rodinn\u00e9 z\u00e1zem\u00ed. To je velmi d\u016fle\u017eit\u00e9 pro to, zda a jak je schopen l\u00e9\u010dbu dodr\u017eovat,\u201c <\/i>\u0159\u00edk\u00e1 prof. MUDr. Tom\u00e1\u0161 Papaj\u00edk, CSc., p\u0159ednosta Hemato-onkologick\u00e9 kliniky Fakultn\u00ed nemocnice Olomouc (FNOL).<\/p>\n O studii, stejn\u011b jako o novink\u00e1ch v oblasti chorob krvetvorby, se budou bavit stovky hematolog\u016f z cel\u00e9 republiky i ze zahrani\u010dn\u00ed na leto\u0161n\u00edch Olomouck\u00fdch hematologick\u00fdch dnech, kter\u00e9 startuj\u00ed 26. kv\u011btna a kon\u010d\u00ed 28. 5. v olomouck\u00e9m kongresov\u00e9m centru.<\/p>\n V sobotu, den p\u0159ed startem, po\u0159\u00e1daj\u00ed organiz\u00e1to\u0159i tradi\u010dn\u011b Pacientsk\u00fd den<\/strong>, kdy se pacienti setk\u00e1vaj\u00ed se sv\u00fdmi l\u00e9ka\u0159i a mohou si poslechnout zaj\u00edmav\u00e9 p\u0159edn\u00e1\u0161ky.<\/p>\n V\u00edce ne\u017e 100 pacient\u016f, kte\u0159\u00ed prod\u011blali rakovinu krve nebo s\u00a0touto nemoc\u00ed aktu\u00e1ln\u011b bojuj\u00ed, se setk\u00e1 tuto sobotu se sv\u00fdmi l\u00e9ka\u0159i na Pacientsk\u00e9m dnu v\u00a0Olomouci.\u00a0<\/b><\/p>\n Motivaci sv\u00fdm l\u00e9ka\u0159\u016fm p\u0159in\u00e1\u0161\u00ed nap\u0159\u00edklad Ivan Kocm\u00e1nek (45), kter\u00e9mu diagnostikovali akutn\u00ed myeloidn\u00ed leukemii ve 40 letech. \u201eNejd\u0159\u00edv l\u00e9ka\u0159i samoz\u0159ejm\u011b hledali d\u00e1rce u n\u00e1s v\u00a0rodin\u011b, ale bohu\u017eel nikdo nem\u011bl dostate\u010dnou shodu. Musel jsem tedy \u010dekat na d\u00e1rce z\u00a0registru,\u201c<\/i> vzpom\u00edn\u00e1 a pokra\u010duje: \u201eNa\u0161t\u011bst\u00ed jsem se za 4 m\u011bs\u00edce do\u010dkal a vhodn\u00fd d\u00e1rce se na\u0161el. To mi zachr\u00e1nilo \u017eivot.\u201c<\/i><\/p>\n \u010cas je v\u00a0t\u011bchto chv\u00edl\u00edch rozhoduj\u00edc\u00ed. \u010c\u00edm d\u0159\u00edve se vhodn\u00fd d\u00e1rce najde, t\u00edm v\u011bt\u0161\u00ed \u0161anci na p\u0159e\u017eit\u00ed nemocn\u00fd m\u00e1. \u201eVe chv\u00edli, kdy jsem se dozv\u011bd\u011bl diagn\u00f3zu, se mi zhroutil sv\u011bt. Te\u010f jsem ale op\u011bt \u0161\u0165astn\u00fd, m\u00e1m dv\u011b skv\u011bl\u00e9 dcery a loni se mi narodil syn. Tomu, \u017ee m\u011b m\u016f\u017ee potkat n\u011bco tak \u00fa\u017easn\u00e9ho, bych p\u0159i \u010dek\u00e1n\u00ed na transplantaci nev\u011b\u0159il,\u201c<\/i> dod\u00e1v\u00e1 pan Ivan.<\/p>\n Stejn\u00e9 pocity za\u017e\u00edv\u00e1 i pan Petr Hyn\u010dica. \u201eP\u0159i \u010dek\u00e1n\u00ed na to, jestli pro m\u011b l\u00e9ka\u0159i najdou vhodn\u00e9ho d\u00e1rce kostn\u00ed d\u0159en\u011b, jsem byl \u00fapln\u011b na dn\u011b. Ani samotn\u00e1 transplantace pro m\u011b nebyla v\u016fbec jednoduch\u00e1, ale d\u00edky skv\u011bl\u00e9mu p\u0159\u00edstup\u016f l\u00e9ka\u0159\u016f a sest\u0159i\u010dek v\u00a0olomouck\u00e9 nemocnici jsem to nakonec zvl\u00e1dl a te\u010f se pomalu vrac\u00edm do \u201enorm\u00e1lu\u201c. Jsem vd\u011b\u010dn\u00fd v\u0161em, kte\u0159\u00ed se odv\u00e1\u017e\u00ed a do registru d\u00e1rc\u016f kostn\u00ed d\u0159en\u011b vstoup\u00ed, m\u011b jeden z\u00a0nich zachr\u00e1nil \u017eivot.\u201c<\/i><\/p>\n N\u00e1rodn\u00ed registr d\u00e1rc\u016f kostn\u00ed d\u0159en\u011b eviduje kolem 80\u00a0000 d\u00e1rc\u016f, pot\u0159eba by bylo minim\u00e1ln\u011b 200\u00a0000 registrovan\u00fdch d\u00e1rc\u016f.<\/p>\n Pacientsk\u00fd den startuje v Clarion Congress Hotelu Olomouc v\u00a0sobotu 25. kv\u011btna v\u00a08.30 hodin. Hlavn\u00edmi t\u00e9maty leto\u0161n\u00edho ro\u010dn\u00edku budou rizika alternativn\u00ed l\u00e9\u010dby v\u00a0onkologii a vliv na\u0161ich emoc\u00ed na imunitn\u00ed syst\u00e9m a zdrav\u00ed. V\u00edce informac\u00ed lze naj\u00edt na www.olhemdny.cz<\/a><\/u><\/span>.<\/p>\n Akci po\u0159\u00e1d\u00e1 Haimaom, nadace na podporu transplantace kostn\u00ed d\u0159en\u011b ve spolupr\u00e1ci s LF UP v Olomouci a Hemato-onkologickou klinikou FNOL a LF UP v Olomouci.<\/p>\n","protected":false},"excerpt":{"rendered":" \u010ce\u0161t\u00ed hematologov\u00e9 ve spolupr\u00e1ci se zahrani\u010dn\u00edmi kolegy letos zahajuj\u00ed studii\u00a0 l\u00e9\u010dby d\u011bt\u00ed s akutn\u00ed leukemi\u00ed. Do n\u011bkolikalet\u00e9 studie nov\u00fdch mo\u017enost\u00ed l\u00e9\u010dby p\u0159ijmou p\u0159ibli\u017en\u011b 1500 d\u011bt\u00ed.<\/p>\n<\/div>","protected":false},"author":1,"featured_media":14373,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-31680","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/31680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31680"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/31680\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14373"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}