{"id":31908,"date":"2019-07-03T14:10:50","date_gmt":"2019-07-03T12:10:50","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=31908"},"modified":"2019-07-03T14:10:50","modified_gmt":"2019-07-03T12:10:50","slug":"vedci-zrejme-objevili-novy-lek-proti-rakovine","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=31908","title":{"rendered":"V\u011bdci z\u0159ejm\u011b objevili nov\u00fd l\u00e9k proti rakovin\u011b"},"content":{"rendered":"

Stra\u0161\u00e1k, kter\u00fd p\u0159edstavuje onemocn\u011bn\u00ed rakovinou, by se \u010dasem mohl st\u00e1t o n\u011bco men\u0161\u00edm bub\u00e1kem ne\u017e dnes. Usiluj\u00ed o to v\u011bdeck\u00e9 t\u00fdmy pracuj\u00edc\u00ed v centru Biocev ve Vestci na Praze-z\u00e1pad.<\/strong> <\/p>\n

Zam\u011b\u0159uj\u00ed se na b\u00e1d\u00e1n\u00ed, jak nejnov\u011bj\u0161\u00ed technologie a pochopen\u00ed fungov\u00e1n\u00ed organismu na bun\u011b\u010dn\u00e9 \u00farovni vyu\u017e\u00edt ke zdokonalen\u00ed medic\u00edny. Ve prosp\u011bch pacient\u016f.<\/p>\n

PROJEKTY PROTI N\u00c1DOR\u016eM<\/p>\n

V oblasti v\u00fdzkumu spojen\u00e9ho s n\u00e1dorov\u00fdm bujen\u00edm se ji\u017e r\u00fdsuj\u00ed velmi nad\u011bjn\u00e9 v\u00fdsledky, p\u0159ipomn\u011bl \u0159editel centra Biocev Pavel Mart\u00e1sek, kter\u00fd je sou\u010dasn\u011b p\u0159edsedou Rady pro konkurenceschopnost St\u0159edo\u010desk\u00e9ho kraje (a tak\u00e9 t\u0159eba \u010dlenem p\u0159edstavenstva St\u0159edo\u010desk\u00e9ho inova\u010dn\u00edho centra).<\/p>\n

„V t\u00e9to oblasti aktu\u00e1ln\u011b prob\u00edhaj\u00ed dva velk\u00e9 projekty. Prvn\u00edm z nich je nov\u00e1 protirakovinn\u00e1 l\u00e1tka MitoTam z laborato\u0159\u00ed profesora Ji\u0159\u00edho Neu\u017eila. Dal\u0161\u00edm v\u00fdzkumem jsou takzvan\u00e1 migrastatika, kter\u00fdmi se zab\u00fdv\u00e1 laborato\u0159 docenta Jana Br\u00e1bka,“ upozornil Mart\u00e1sek na v\u00fdzkumy, je\u017e maj\u00ed nad\u011bji zapsat se nejenom do v\u011bdeck\u00fdch publikac\u00ed. Zat\u00edm to vypad\u00e1, \u017ee by mohly dok\u00e1zat i „p\u0159episovat“ lidsk\u00e9 osudy.<\/p>\n

Migrastatika v\u011bdci pojmenovali skute\u010dn\u011b podle cestov\u00e1n\u00ed \u2013 migrace. Na rozd\u00edl od dosavadn\u00ed l\u00e9\u010dby pomoc\u00ed cytostatik, je\u017e omezuje r\u016fst a d\u011blen\u00ed n\u00e1dorov\u00fdch bun\u011bk a \u010dasto zas\u00e1hne i zdrav\u00e9 bu\u0148ky, nov\u00e9 l\u00e9\u010debn\u00e9 postupy zkouman\u00e9 Br\u00e1bkov\u00fdm t\u00fdmem maj\u00ed p\u016fsobit jinak: br\u00e1nit agresivn\u00edm bu\u0148k\u00e1m v „cestov\u00e1n\u00ed“ po organismu. \u0158e\u010d ov\u0161em nen\u00ed o mo\u017en\u00e9m nahrazen\u00ed cytostatik zastavuj\u00edc\u00edch n\u00e1dorov\u00e9 bujen\u00ed migrastatiky k omezen\u00ed vzniku metast\u00e1z. Nov\u00e9 nad\u011bje pro pacienty by m\u011bly spo\u010d\u00edvat v jejich ide\u00e1ln\u00ed kombinaci. A v\u00fdhled na zlep\u0161en\u00ed je vysok\u00fd: pr\u00e1v\u011b vznik metast\u00e1z p\u0159edstavuje z 90 procent p\u0159\u00ed\u010dinu \u00famrt\u00ed pacient\u016f s pevn\u00fdmi n\u00e1dory.<\/p>\n

NOV\u00dd L\u00c9K SE U\u017d TESTUJE<\/p>\n

Pokud jde o MitoTam, prepar\u00e1t zac\u00edlen\u00fd na \u010dinnost mitochondri\u00ed (organel laicky p\u0159irovn\u00e1van\u00fdch k \u010dinnosti „elektr\u00e1ren“ nezbytn\u00fdch pro fungov\u00e1n\u00ed jak bun\u011bk zdrav\u00fdch, tak i n\u00e1dorov\u00fdch), prvotn\u00ed poznatky z experiment\u00e1ln\u00ed l\u00e9\u010dby nazna\u010duj\u00ed \u00fa\u010dinnost proti rakovin\u011b prsu i dal\u0161\u00edm n\u00e1dorov\u00fdm onemocn\u011bn\u00edm. „Potenci\u00e1ln\u00ed l\u00e9k je nyn\u00ed testov\u00e1n ve V\u0161eobecn\u00e9 fakultn\u00ed nemocnici v Praze \u2013 a v brzk\u00e9 dob\u011b lze o\u010dek\u00e1vat v\u00fdsledky prvn\u00ed f\u00e1ze klinick\u00fdch test\u016f,“ potvrdil \u0159editel Mart\u00e1sek, \u017ee tady u\u017e rozhodn\u011b nen\u00ed \u0159e\u010d jen o pr\u00e1ci ve v\u00fdzkumn\u00fdch laborato\u0159\u00edch. P\u0159\u00edmo v nemocni\u010dn\u00ed praxi ji\u017e rok ov\u011b\u0159uje \u00fa\u010dinnost t\u00fdm onkologa Lubo\u0161e Petru\u017eelky.<\/p>\n

V\u00fdzkumn\u00e9 t\u00fdmy pracuj\u00edc\u00ed ve Vestci u Prahy se v\u0161ak nezam\u011b\u0159uj\u00ed pouze na boj s n\u00e1dorov\u00fdmi onemocn\u011bn\u00edmi. Z dal\u0161\u00edch oblast\u00ed v\u00fdzkumu vyzdvihl \u0159editel Mart\u00e1sek nap\u0159\u00edklad kardiovaskul\u00e1rn\u00ed choroby, metabolick\u00e1 i neurodegenerativn\u00ed onemocn\u011bn\u00ed nebo takzvan\u00e9 vz\u00e1cn\u00e9 choroby (rare diseases), jimi\u017e se rozum\u00ed \u017eivot ohro\u017euj\u00edc\u00ed nebo z\u00e1va\u017en\u00e1 chronick\u00e1 onemocn\u011bn\u00ed zhor\u0161uj\u00edc\u00ed kvalitu \u017eivota posti\u017een\u00fdch, postihuj\u00edc\u00ed jen mal\u00e9 procento populace. „Jejich prevalence je men\u0161\u00ed ne\u017e p\u011bt osob z deseti tis\u00edc,“ up\u0159esnil Mart\u00e1sek.<\/p>\n

—————-<\/p>\n

V\u00fdzkumn\u00e9 centrum Biocev ve Vestci<\/p>\n

– Biocev ve Vestci je spole\u010dn\u00fdm projektem dvou fakult Univerzity Karlovy a \u0161esti \u00fastav\u016f Akademie v\u011bd \u010cR, jejich\u017e spole\u010dn\u00fdm c\u00edlem je detailn\u00ed pozn\u00e1n\u00ed organism\u016f na molekul\u00e1rn\u00ed \u00farovni umo\u017e\u0148uj\u00edc\u00ed v\u00fdvoj nov\u00fdch l\u00e9\u010debn\u00fdch postup\u016f<\/p>\n

– Na p\u011bti v\u00fdzkumn\u00fdch programech se pod\u00edlej\u00ed v\u011bdci z oboru molekul\u00e1rn\u00ed a bun\u011b\u010dn\u00e9 biologie, fenogenomiky (obor vyu\u017e\u00edvaj\u00edc\u00ed zkoum\u00e1n\u00ed gen\u016f), strukturn\u00ed biologie, tk\u00e1\u0148ov\u00e9ho in\u017een\u00fdrstv\u00ed a biomedic\u00edny; centrum propojuje \u010dinnost v\u00fdzkumn\u00edk\u016f z r\u016fzn\u00fdch v\u011bdeck\u00fdch discipl\u00edn: z oblasti technick\u00fdch a p\u0159\u00edrodn\u00edch v\u011bd jako jsou virologie, genetika nebo chemie<\/p>\n

– Pln\u011bn\u00ed v\u00fdzkumn\u00fdch \u00fakol\u016f nyn\u00ed zaji\u0161\u0165uje p\u0159es 450 v\u011bdeck\u00fdch a technick\u00fdch pracovn\u00edk\u016f, z nich\u017e t\u00e9m\u011b\u0159 t\u0159etina poch\u00e1z\u00ed ze zahrani\u010d\u00ed; jako z\u00e1jemci o pr\u00e1ci se sami aktivn\u011b hl\u00e1s\u00ed \u010de\u0161t\u00ed i zahrani\u010dn\u00ed v\u011bdci a studenti<\/p>\n

Zdroj: \u0159editel centra Biocev Pavel Mart\u00e1sek<\/p>\n

MILAN HOLAKOVSK\u00dd
\nBene\u0161ovsk\u00fd den\u00edk
\nhttp:\/\/www.benesovsky.denik.cz\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Stra\u0161\u00e1k, kter\u00fd p\u0159edstavuje onemocn\u011bn\u00ed rakovinou, by se \u010dasem mohl st\u00e1t o n\u011bco men\u0161\u00edm bub\u00e1kem ne\u017e dnes. Usiluj\u00ed o to v\u011bdeck\u00e9 t\u00fdmy pracuj\u00edc\u00ed v centru Biocev […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14877,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-31908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/31908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31908"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/31908\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14877"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}