Ur\u010dit, kter\u00e9 pacientky s n\u00e1dorem prsu jsou n\u00e1chyln\u011bj\u0161\u00ed ke vzniku ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f po chemoterapeutick\u00e9 l\u00e9\u010db\u011b, by mohli l\u00e9ka\u0159i z Masarykova onkologick\u00e9ho \u00fastavu v Brn\u011b. Skon\u010dit by mohlo brn\u011bn\u00ed \u010di necitlivost prst\u016f u nohou nebo zhor\u0161en\u00ed jemn\u00e9 motoriky. Kvalita \u017eivota \u017een po vyl\u00e9\u010den\u00ed bude vy\u0161\u0161\u00ed d\u00edky tomu, \u017ee l\u00e9ka\u0159i budou p\u0159edv\u00eddat m\u00edru posti\u017een\u00ed ne\u017e\u00e1douc\u00edmi \u00fa\u010dinky u konkr\u00e9tn\u00edch pacientek.<\/p>\n\n\n\n
Pom\u016f\u017ee jim k tomu v\u00fdzkum nov\u00fdch soubor\u016f specifick\u00fdch protein\u016f v krvi, kter\u00e9 se koncentrac\u00ed nebo strukturou li\u0161\u00ed od zdrav\u00fdch jedinc\u016f. Nezbytnou sou\u010d\u00e1st\u00ed v\u00fdzkumu jsou anal\u00fdzy vyu\u017e\u00edvaj\u00edc\u00ed hmotnostn\u00ed spektrometr. Nov\u00fd p\u0159\u00edstroj tak zdokonal\u00ed v\u00fdzkum onkologick\u00fdch onemocn\u011bn\u00ed.<\/p>\n\n\n\n
\u201eV \u010cesk\u00e9 republice ka\u017edoro\u010dn\u011b m\u00e1me v\u00edce ne\u017e sedm tis\u00edc nov\u011b diagnostikovan\u00fdch pacientek s karcinomem prsu. P\u0159esto\u017ee po\u010det pacientek s touto diagn\u00f3zou nar\u016fst\u00e1, \u00famrtnost z\u016fst\u00e1v\u00e1 stejn\u00e1. \u010c\u00edm d\u00e1l v\u00edce pacientek jsme tedy schopni vyl\u00e9\u010dit. Na\u0161\u00edm c\u00edlem je v\u0161ak i to, aby pacientky m\u011bly co nejm\u00e9n\u011b trval\u00fdch n\u00e1sledk\u016f zp\u016fsoben\u00fdch onkologickou l\u00e9\u010dbou,\u201c uvedl n\u00e1m\u011bstek l\u00e9\u010debn\u011b preventivn\u00ed p\u00e9\u010de Igor Kiss.<\/p>\n\n\n\n
\u017deny po chemoterapeutick\u00e9 l\u00e9\u010db\u011b se toti\u017e mohou pot\u00fdkat s do\u017eivotn\u00edm posti\u017een\u00edm perifern\u00edch nerv\u016f. To se projevuje brn\u011bn\u00edm \u010di necitlivost\u00ed prst\u016f na nohou a rukou \u010di zhor\u0161en\u00edm jemn\u00e9 motoriky. Probl\u00e9mem pak pro pacientku m\u016f\u017ee b\u00fdt i zav\u00e1zat si tkani\u010dku u bot nebo si zapnout knofl\u00edk. Ch\u016fze ze schod\u016f pak m\u016f\u017ee b\u00fdt pro \u010dlov\u011bka s t\u00edmto posti\u017een\u00edm t\u00e9m\u011b\u0159 nemo\u017en\u00e1. Posti\u017een\u00edm perifern\u00edch nerv\u016f p\u0159itom m\u016f\u017ee trp\u011bt a\u017e osmdes\u00e1t procent pacientek l\u00e9\u010den\u00fdch ur\u010dit\u00fdm typem chemoterapie.<\/p>\n\n\n\n
\u201eSna\u017e\u00edme se zjistit rozd\u00edl, v \u010dem se jednotliv\u00e9 pacientky li\u0161\u00ed. Pro\u010d u n\u011bkter\u00fdch neuropatie vznikne, u jin\u00fdch ne, u n\u011bkter\u00fdch pouze m\u00edrn\u00fd stupe\u0148, u dal\u0161\u00edch naopak velmi v\u00fdznamn\u00e9 posti\u017een\u00ed, \u017ee nemohou t\u0159eba chodit ze schod\u016f, proto\u017ee kv\u016fli neuropatii nec\u00edt\u00ed, \u017ee do\u0161l\u00e1ply. Mohou to b\u00fdt symptomy, kter\u00e9 velmi v\u00fdznamn\u011b ovliv\u0148uj\u00ed kvalitu \u017eivota pacientek. C\u00edlem projektu je tak naj\u00edt n\u011bjak\u00e9 biomarkery pro p\u0159edv\u00edd\u00e1n\u00ed neurotoxicity, abychom mohli je\u0161t\u011b p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby identifikovat \u017eeny, kte\u0159\u00ed maj\u00ed to riziko posti\u017een\u00ed nejvy\u0161\u0161\u00ed,\u201c sd\u011blil Kiss.<\/p>\n\n\n\n
L\u00e9ka\u0159i jim pak uprav\u00ed l\u00e9\u010dbu na m\u00edru. Jednou z mo\u017enost\u00ed je zvolen\u00ed n\u00e1hradn\u00ed l\u00e9\u010dby. C\u00edlem v\u00fdzkumu je v\u0161ak do budoucna podobn\u00fdm \u00fa\u010dink\u016fm zamezit. Dan\u00fd typ chemoterapie je toti\u017e pro pacientky s n\u00e1dory prsu velmi efektivn\u00ed. Stejn\u00e1 se nav\u00edc pou\u017e\u00edv\u00e1 pro onemocn\u011bn\u00ed rakovinou prostaty nebo plic.<\/p>\n\n\n\n
Samostatn\u00fd \u00fastav pro rakovinu prsu<\/p>\n\n\n\n
V\u00fdzkumu rakoviny prsu se aku\u00e1ln\u011b v\u011bnuj\u00ed v samotn\u00e9m \u00fastavu. Masaryk\u016fv onkologick\u00fd \u00fastav m\u00e1 toti\u017e vlastn\u00ed v\u00fdzkumn\u00e9 pracovi\u0161t\u011b zam\u011b\u0159uj\u00edc\u00ed se na oblast n\u00e1dorov\u00e9 biologie. V sedmi samostatn\u00fdch v\u00fdzkumn\u00fdch skupin\u00e1ch v n\u011bm pracuje na pades\u00e1t v\u00fdzkumn\u00edk\u016f.<\/p>\n\n\n\n
\u201eDo na\u0161\u00ed studie byly vybr\u00e1ny pacientky se zhoubn\u00fdm n\u00e1dorem prsu, z nich\u017e asi polovina m\u011bla p\u0159\u00edznaky neurotoxicity a druh\u00e1 \u010d\u00e1st byla bez p\u0159\u00edznak\u016f. Od ka\u017ed\u00e9 pacientky jsme vyhodnotili krevn\u00ed vzorek odebran\u00fd p\u0159ed chemoterapeutickou l\u00e9\u010dbou a pak po jej\u00edm ukon\u010den\u00ed. Z\u00e1rove\u0148 byly k dispozici kontroln\u00ed vzorky od zdrav\u00fdch d\u00e1rky\u0148,\u201c popsala klinick\u00e1 onkolo\u017eka a vedouc\u00ed l\u00e9ka\u0159ka Centra prevence Jana Hal\u00e1mkov\u00e1.<\/p>\n\n\n\n
V\u0161echny vzorky krve putovaly do v\u00fdzkumn\u00e9ho pracovi\u0161t\u011b, kter\u00e9 anal\u00fdzou krve za\u010dalo hledat nov\u00e9 biomarkery. Pro anal\u00fdzu krve je p\u0159itom hmotnostn\u00ed spektrometr kl\u00ed\u010dov\u00fd.<\/p>\n\n\n\n
\u201eNa\u0161\u00edm c\u00edlem je naj\u00edt v krvi pacientek, u kter\u00fdch se v pr\u016fb\u011bhu nebo po l\u00e9\u010db\u011b vyskytla neurotoxicita, glykoproteiny s definovan\u00fdmi glykanov\u00fdmi strukturami p\u0159\u00edtomn\u00fdmi unik\u00e1tn\u011b nebo v pozm\u011bn\u011bn\u00e9 koncentraci p\u0159ed chemoterapeutickou l\u00e9\u010dbou,\u201c vysv\u011btlila vedouc\u00ed jedn\u00e9 z v\u00fdzkumn\u00fdch skupin Lenka Hernychov\u00e1.<\/p>\n\n\n\n
Tereza H\u00e1lov\u00e1<\/p>\n\n\n\n
T\u0159eb\u00ed\u010dsk\u00fd den\u00edk<\/p>\n\n\n\n
https:\/\/trebicsky.denik.cz\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Ur\u010dit, kter\u00e9 pacientky s n\u00e1dorem prsu jsou n\u00e1chyln\u011bj\u0161\u00ed ke vzniku ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f po chemoterapeutick\u00e9 l\u00e9\u010db\u011b, by mohli l\u00e9ka\u0159i z Masarykova onkologick\u00e9ho \u00fastavu v Brn\u011b. Skon\u010dit by mohlo brn\u011bn\u00ed […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":27888,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-38514","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/38514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38514"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/38514\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/27888"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=38514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=38514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}