Kdy\u017e bylo Jan\u011b Pol\u00e1\u0161kov\u00e9 dvaadvacet let, dozv\u011bd\u011bla se, \u017ee m\u00e1 leuk\u00e9mii a mus\u00ed podstoupit transplantaci kostn\u00ed d\u0159en\u011b. Stala se tak jednou z pacientek stoj\u00edc\u00ed na po\u010d\u00e1tku fungov\u00e1n\u00ed Transplanta\u010dn\u00edho programu Intern\u00ed hematologick\u00e9 a onkologick\u00e9 kliniky, kter\u00fd za\u010dal v brn\u011bnsk\u00e9 Fakultn\u00ed nemocnici fungovat p\u0159ed t\u0159iceti lety. Dnes je nejv\u011bt\u0161\u00edm hematoonkologick\u00fdm pracovi\u0161t\u011bm v \u010cesk\u00e9 republice a p\u0159esto\u017ee Pol\u00e1\u0161kov\u00e1 dnes podle sv\u00fdch slov \u017eije plnohodnotn\u00fdm \u017eivotem, transplantace kostn\u00ed d\u0159en\u011b, kter\u00e1 je pova\u017eov\u00e1na za jednu z nejslo\u017eit\u011bj\u0161\u00edch medic\u00ednsk\u00fdch procedur, pro\u0161la za t\u0159icet let velk\u00fdm v\u00fdvojem.<\/p>\n\n\n\n
\u201ePrincip je podobn\u00fd, ale z hlediska toho, kolik m\u00e1me dnes na sv\u011bt\u011b spolupracuj\u00edc\u00edch registr\u016f d\u00e1rc\u016f, jak\u00e9 m\u00e1me diagnostick\u00e9 metody, jak v\u00edme, kdy spr\u00e1vn\u011b transplantaci prov\u00e9st, jak kostn\u00ed d\u0159e\u0148 zlikvidovat a sou\u010dasn\u011b co nejm\u00e9n\u011b po\u0161kodit zbyl\u00e9 org\u00e1ny, jak jsme schopni diagnostikovat nejr\u016fzn\u011bj\u0161\u00ed komplikace a zvl\u00e1dat infekce, jsme \u00fapln\u011b n\u011bkde jinde. Dnes m\u016f\u017eeme nap\u0159\u00edklad m\u011b\u0159it funkci transplant\u00e1tu, co\u017e z b\u011b\u017en\u00e9ho krevn\u00edho obrazu nepozn\u00e1me. Dozv\u00edme se, kolik je p\u0159e\u017eiv\u0161\u00edch \u010derven\u00fdch krvinek od pacienta a jak transplant\u00e1t funguje. M\u016f\u017eete tak\u00e9 zjistit, jestli tam nez\u016fstaly zatoulan\u00e9 leukemick\u00e9 bu\u0148ky,\u201d popsal p\u0159ednosta Intern\u00ed hematologick\u00e9 a onkologick\u00e9 kliniky Ji\u0159\u00ed Mayer.<\/p>\n\n\n\n
Jednou z nejz\u00e1sadn\u011bj\u0161\u00edch zm\u011bn je, \u017ee tradi\u010dn\u00ed odb\u011br kostn\u00ed d\u0159en\u011b, vy\u017eaduj\u00edc\u00ed jej\u00ed odebr\u00e1n\u00ed opakovan\u00fdmi vpichy do p\u00e1nevn\u00ed kosti, nahradil odb\u011br krvetvorn\u00fdch bun\u011bk p\u0159\u00edmo z krve. L\u00e9ka\u0159i toti\u017e p\u0159i\u0161li na to, \u017ee tyto bu\u0148ky, kter\u00e9 jsou alfou a omegou cel\u00e9 l\u00e9\u010dby, se nach\u00e1zej\u00ed nejen v kostn\u00ed d\u0159eni, kde vznikaj\u00ed, ale rovn\u011b\u017e v krvi samotn\u00e9.<\/p>\n\n\n\n
Nam\u00edsto bolestiv\u00e9ho z\u00e1kroku, kter\u00fd vy\u017eadoval celkovou nark\u00f3zu d\u00e1rce, je dnes doty\u010dn\u00fd pouze napojen\u00fd hadi\u010dkami na p\u0159\u00edstroj, kter\u00fd mu krvetvorn\u00e9 bu\u0148ky z krve s\u00e1m odd\u011bluje. Z\u00e1krok je tedy bezbolestn\u00fd, obejde se bez celkov\u00e9 anestezie a d\u00e1rce b\u011bhem n\u011bj m\u016f\u017ee sp\u00e1t, \u010d\u00edst si nebo se koukat na televizi.<\/p>\n\n\n\n
Modern\u00ed l\u00e9\u010dba v\u0161ak u\u017e s transplantac\u00ed v\u016fbec nepo\u010d\u00edt\u00e1. Takzvan\u00e1 bun\u011b\u010dn\u00e1 genov\u00e1 terapie zahrnuje pou\u017eit\u00ed pacientov\u00fdch vlastn\u00edch b\u00edl\u00fdch krvinek, kter\u00e9 jsou genetickou \u00fapravou vycvi\u010deny k rozpozn\u00e1v\u00e1n\u00ed n\u00e1doru.<\/p>\n\n\n\n
\u201eBu\u0148ky odebereme, farmaceutick\u00e1 firma do nich vlo\u017e\u00ed p\u0159\u00edslu\u0161n\u00fd gen, kter\u00fd rozpozn\u00e1 c\u00edlov\u00fd n\u00e1dor, bu\u0148ky n\u00e1m po\u0161lou zp\u011bt a my je op\u011bt pod\u00e1me pacientovi,\u201d vysv\u011btlil Franti\u0161ek Folber ze Separa\u010dn\u00edho st\u0159ediska, kter\u00e9 je sou\u010d\u00e1st\u00ed kliniky. Pod\u00e1n\u00ed p\u0159itom prob\u00edh\u00e1 podobn\u011b jako transf\u00faze.<\/p>\n\n\n\n
K transplantaci kostn\u00ed d\u0159en\u011b doch\u00e1z\u00ed v p\u0159\u00edpad\u011b jej\u00edho posti\u017een\u00ed, nej\u010dast\u011bji v d\u016fsledku n\u00e1dorov\u00e9 leuk\u00e9mie. P\u0159istupuje se k n\u00ed ale i v p\u0159\u00edpad\u011b, kdy se v t\u011ble pacienta nach\u00e1z\u00ed jin\u00fd agresivn\u00ed n\u00e1dor, kter\u00fd vy\u017eaduje intenzivn\u00ed l\u00e9\u010dbu vedouc\u00ed k likvidaci pacientovy kostn\u00ed d\u0159en\u011b.<\/p>\n\n\n\n
Za t\u0159icet let fungov\u00e1n\u00ed Transplanta\u010dn\u00edho programu Intern\u00ed hematologick\u00e9 a onkologick\u00e9 kliniky bylo v brn\u011bnsk\u00e9 Fakultn\u00ed nemocnici provedeno p\u0159ibli\u017en\u011b t\u0159i tis\u00edce transplantac\u00ed kostn\u00ed d\u0159en\u011b a krvetvorn\u00fdch bun\u011bk. I s genovou terapi\u00ed ro\u010dn\u011b l\u00e9ka\u0159i provedou na sto takov\u00fdch \u00fakon\u016f. N\u00e1r\u016fst byl p\u0159itom pom\u011brn\u011b rychl\u00fd.<\/p>\n\n\n\n
Zat\u00edmco v roce 1993 byla provedena prvn\u00ed transplantace kostn\u00ed d\u0159en\u011b, o dva roky pozd\u011bji to byly des\u00edtky z\u00e1krok\u016f ro\u010dn\u011b a v posledn\u00edch letech jich zvl\u00e1daj\u00ed stovky.<\/p>\n\n\n\n
\u201eJe to intenzivn\u00ed rutinn\u00ed provoz, ka\u017ed\u00fd t\u0159et\u00ed \u010dtvrt\u00fd den prob\u011bhne na na\u0161em pracovi\u0161ti jedna transplantace,\u201d dodal Mayer.<\/p>\n\n\n\n
Tereza H\u00e1lov\u00e1<\/p>\n\n\n\n
Brn\u011bnsk\u00fd den\u00edk<\/p>\n\n\n\n
https:\/\/brnensky.denik.cz\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Kdy\u017e bylo Jan\u011b Pol\u00e1\u0161kov\u00e9 dvaadvacet let, dozv\u011bd\u011bla se, \u017ee m\u00e1 leuk\u00e9mii a mus\u00ed podstoupit transplantaci kostn\u00ed d\u0159en\u011b. Stala se tak jednou z pacientek stoj\u00edc\u00ed na […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14587,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-38991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/38991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38991"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/38991\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14587"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=38991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=38991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}