\u010cesk\u00fd rozhlas o jedn\u00e9 l\u00e9kov\u00e9 novince. Revmatoidn\u00ed artritidu by mo\u017en\u00e1 bylo mo\u017en\u00e9 l\u00e9\u010dit efektivn\u011bji a p\u0159edev\u0161\u00edm bez vedlej\u0161\u00edch \u00fa\u010dink\u016f, z\u00e1n\u011bty v kloubech p\u0159i n\u00ed zp\u016fsobuje p\u0159ehnan\u00e1 \u010dinnost imunitn\u00edho syst\u00e9mu, na artritidu se p\u0159edepisuj\u00ed l\u00e9ky, kter\u00e9 potla\u010duj\u00ed pr\u00e1v\u011b imunitu, jen\u017ee ty samoz\u0159ejm\u011b funguj\u00ed nejen v m\u00edst\u011b z\u00e1n\u011btu. V\u011bdci z Akademie v\u011bd a Masarykovy univerzity a mezin\u00e1rodn\u00edho centra klinick\u00e9ho v\u00fdzkumu proto v sou\u010dasnosti testuj\u00ed tzv. nanop\u0159ena\u0161e\u010de, kter\u00e9 l\u00e9ky doprav\u00ed p\u0159\u00edmo do kloub\u016f, ani\u017e by potla\u010dily imunitu v cel\u00e9m pacientov\u011b t\u011ble.
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Pan\u00ed \u0159editelko, jak se da\u0159\u00ed? Co va\u0161e klouby v minul\u00e9 n\u00e1v\u0161t\u011bv\u011b.
mluv\u010d\u00ed 11,
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No, \u0161estadvac\u00e1t\u00fdho mi otekl mal\u00ed\u010dek docela brut\u00e1ln\u011b, te\u010f u\u017e to m\u00e1m jako v pohod\u011b.
mluv\u010d\u00ed 12,
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A \u010delistn\u00ed kloub. Revmatolog Petr N\u011bmec vy\u0161et\u0159uje pacientku s artritidou, revmatoidn\u00ed artritida je autoimunitn\u00ed onemocn\u011bn\u00ed, imunitn\u00ed bu\u0148ky. Za\u010dnou v podstat\u011b bezd\u016fvodn\u011b vytv\u00e1\u0159et z\u00e1n\u011bt nej\u010dast\u011bji v kloubech.
mluv\u010d\u00ed 11,
——————–
No, beru ten metodrixat a k tomu biologickou l\u00e9\u010dbu, zji\u0161\u0165uju, \u017ee m\u00e1m sn\u00ed\u017eenou imunitu, proto\u017ee docela \u010dasto trp\u00edm nachlazen\u00edm, z\u00e1n\u011btem dutin.
mluv\u010d\u00ed 12,
——————–
Toto b\u00fdvaj\u00ed \u010dast\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky sou\u010dasn\u00e9 l\u00e9\u010dby revmatoidn\u00ed artritidy, vysv\u011btluje Daniela Rubanov\u00e1 z biofyzik\u00e1ln\u00edho \u00fastavu Akademie v\u011bd \u010cesk\u00e9 republiky.
Ta l\u00e9\u010dba jim tlum\u00ed obecn\u011b jejich imunitn\u00ed syst\u00e9m. Daniela Rubanov\u00e1 proto s kolegy tato l\u00e9\u010diva vylep\u0161uje, aby vedlej\u0161\u00edch \u00fa\u010dink\u016f zp\u016fsobovaly co nejm\u00e9n\u011b.
Daniela Rubanov\u00e1
——————–
My bychom r\u00e1di nav\u00e1zali ta sou\u010dasn\u011b pou\u017e\u00edvan\u00e1 terapeutika na nanopolymern\u00ed nosi\u010de, kter\u00e9 umo\u017en\u00ed jej specificky c\u00edlit do toho zan\u00edcen\u00e9ho kloubu.
——————–
Tento nosi\u010d je molekula, kter\u00e1 funkci l\u00e9k\u016f v podstat\u011b vypne, a to a\u017e do chv\u00edle, ne\u017e se dostane do m\u00edsta z\u00e1n\u011btu, tam je kyselej\u0161\u00ed pH, co\u017e molekulu nosi\u010de od l\u00e9ku odd\u011bl\u00ed a l\u00e9k za\u010dne \u00fa\u010dinkovat, tedy potla\u010dovat imunitu. To ale bylo pot\u0159eba otestovat.
——————–
Zde vid\u00edme sn\u00ed\u017een\u00ed produkce toho proz\u00e1n\u011btliv\u00e9ho medi\u00e1toru.
——————–
Tak\u017ee opravdu ten nanop\u0159ena\u0161e\u010d odpadne a l\u00e9\u010divo za\u010dne fungovat. Ten z\u00e1n\u011bt bude potla\u010den.
——————–
V\u00fdzkumn\u00edci l\u00e9k vyzkou\u0161eli i na my\u0161\u00edch.
——————–
Toto je obr\u00e1zek jednoho z na\u0161ich model\u016f. Na t\u00e9to kon\u010detin\u011b my\u0161i byla indukov\u00e1na artritida.
mluv\u010d\u00ed 12,
——————–
A pak jste ji l\u00e9\u010dili.
Daniela Rubanov\u00e1
——————–
Ano A v pr\u016fb\u011bhu \u010dasu jsme sledovali, jak doch\u00e1z\u00ed k poklesu otoku v t\u00e9to nemocn\u00e9 noze.
mluv\u010d\u00ed 12,
——————–
Tyto p\u0159edklinick\u00e9 studie ukazuj\u00ed, \u017ee l\u00e9\u010divo s nanosi\u010di l\u00e9pe c\u00edl\u00ed na m\u00edsto z\u00e1n\u011btu a p\u016fsob\u00ed d\u00e9le. I proto jsou \u00fa\u010dinn\u00e9 i ni\u017e\u0161\u00ed d\u00e1vky, ne\u017e je tomu u sou\u010dasn\u00fdch l\u00e9\u010div. Podle v\u011bdc\u016f bude hotov\u00e9 nejd\u0159\u00edve za sedm let. <\/p>\n\n\n\n
\u010cesk\u00fd rozhlas.
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u010cesk\u00fd rozhlas o jedn\u00e9 l\u00e9kov\u00e9 novince. Revmatoidn\u00ed artritidu by mo\u017en\u00e1 bylo mo\u017en\u00e9 l\u00e9\u010dit efektivn\u011bji a p\u0159edev\u0161\u00edm bez vedlej\u0161\u00edch \u00fa\u010dink\u016f, z\u00e1n\u011bty v kloubech p\u0159i n\u00ed zp\u016fsobuje […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":15606,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-45155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/45155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45155"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/45155\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/15606"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}