{"id":47148,"date":"2024-03-18T10:21:59","date_gmt":"2024-03-18T09:21:59","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=47148"},"modified":"2024-03-18T10:22:05","modified_gmt":"2024-03-18T09:22:05","slug":"vyzkum-ukazuje-nove-perspektivy-v-lecbe-a-regeneraci","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=47148","title":{"rendered":"V\u00fdzkum ukazuje nov\u00e9 perspektivy v l\u00e9\u010db\u011b a regeneraci"},"content":{"rendered":"\n

 Trendy p\u0159i vyu\u017e\u00edv\u00e1n\u00ed pupe\u010dn\u00edkov\u00e9 krve<\/strong><\/p>\n\n\n\n

V sou\u010dasn\u00e9 dob\u011b je odb\u011br a vyu\u017eit\u00ed pupe\u010dn\u00edkov\u00e9 krve t\u00e9m\u011b\u0159 b\u011b\u017enou prax\u00ed, ale kl\u00ed\u010dov\u00fdm aspektem tohoto procesu je neust\u00e1le se rozv\u00edjej\u00edc\u00ed v\u00fdzkum. Tento v\u00fdzkum roz\u0161i\u0159uje obzory v oblasti l\u00e9ka\u0159stv\u00ed a regenera\u010dn\u00ed medic\u00edny, sm\u011b\u0159uj\u00edc\u00ed k \u00fa\u010dinn\u011bj\u0161\u00edm, rychlej\u0161\u00edm a \u0161etrn\u011bj\u0161\u00edm l\u00e9\u010debn\u00fdm metod\u00e1m. Kmenov\u00e9 bu\u0148ky z pupe\u010dn\u00edkov\u00e9 krve jsou nad\u00e1le intenzivn\u011b studov\u00e1ny v\u011bdci a l\u00e9ka\u0159i z cel\u00e9ho sv\u011bta, kte\u0159\u00ed hledaj\u00ed nov\u00e9 mo\u017enosti vyu\u017eit\u00ed t\u011bchto bun\u011bk nejen v l\u00e9\u010db\u011b zn\u00e1m\u00fdch onemocn\u011bn\u00ed, ale tak\u00e9 v dosud nedot\u010den\u00fdch oblastech.<\/strong><\/p>\n\n\n\n

Kmenov\u00e9 bu\u0148ky lze z\u00edskat z v\u00edce \u010d\u00e1st\u00ed lidsk\u00e9ho t\u011bla. Jednou z nejm\u00e9n\u011b invazivn\u00edch mo\u017enost\u00ed je odb\u011br a uchov\u00e1n\u00ed p\u0159i narozen\u00ed d\u00edt\u011bte \u2013 \u0159\u00edk\u00e1 se jim tak\u00e9 perinat\u00e1ln\u00ed kmenov\u00e9 bu\u0148ky. Tyto bu\u0148ky jsou nejmlad\u0161\u00ed, nejsou ovlivn\u011bny \u017eivotn\u00edm stylem, p\u0159ekonan\u00fdmi \u010di prob\u00edhaj\u00edc\u00edmi chorobami. Oproti kmenov\u00fdm bu\u0148k\u00e1m, kter\u00e9 lze z\u00edskat b\u011bhem dal\u0161\u00edho \u017eivota, tak maj\u00ed mnoh\u00e9 v\u00fdhody.<\/p>\n\n\n\n

V\u00fdjime\u010dn\u00e9 vlastnosti kmenov\u00fdch bun\u011bk<\/strong><\/p>\n\n\n\n

Kmenov\u00e9 bu\u0148ky z pupe\u010dn\u00edkov\u00e9 krve jsou v centru pozornosti medic\u00edny kv\u016fli sv\u00fdm jedine\u010dn\u00fdm vlastnostem. Ka\u017ed\u00fd zdroj kmenov\u00fdch bun\u011bk je jedine\u010dn\u00fd, ale bu\u0148ky z perinat\u00e1ln\u00edch tk\u00e1n\u00ed maj\u00ed tu v\u00fdhodu, \u017ee jsou mlad\u00e9, neovlivn\u011bn\u00e9 \u017eivotn\u00edm stylem a nemocemi, kter\u00fdmi \u010dlov\u011bk proch\u00e1z\u00ed sv\u00fdm \u017eivotem, co zn\u00e1sobuje jejich schopnosti. Tyto bu\u0148ky maj\u00ed schopnost p\u0159em\u011bnit se na r\u016fzn\u00e9 typy bun\u011bk a unik\u00e1tn\u00ed regenera\u010dn\u00ed potenci\u00e1l. Mohou regenerovat po\u0161kozen\u00e1 tk\u00e1n\u011b a obnovovat bu\u0148ky, kter\u00e9 se opot\u0159ebov\u00e1vaj\u00ed. Nav\u00edc maj\u00ed schopnost tlumit z\u00e1n\u011btliv\u00e9 procesy v po\u0161kozen\u00fdch tk\u00e1n\u00edch, co\u017e napom\u00e1h\u00e1 t\u011blu k regeneraci a l\u00e9\u010db\u011b.<\/p>\n\n\n\n

Perinat\u00e1ln\u00ed kmenov\u00e9 bu\u0148ky<\/strong><\/p>\n\n\n\n

Novorozeneck\u00e9 kmenov\u00e9 bu\u0148ky lze z\u00edskat z pupe\u010dn\u00edkov\u00e9 krve, tk\u00e1n\u011b pupe\u010dn\u00edku a placenty. Tyto tk\u00e1n\u011b po porodu ztr\u00e1cej\u00ed svou funkci a \u010dasto kon\u010d\u00ed nevyu\u017eit\u00e9\/ jako biologick\u00fd odpad. Je to v\u0161ak \u0161koda. Jejich odb\u011br a uskladn\u011bn\u00ed p\u0159edstavuje jednoduch\u00fd, neinvazivn\u00ed a bezpe\u010dn\u00fd zp\u016fsob uchov\u00e1n\u00ed v\u00edce typ\u016f kmenov\u00fdch bun\u011bk.<\/p>\n\n\n\n

Placenta \u2013 nov\u00fd, slibn\u00fd zdroj kmenov\u00fdch bun\u011bk<\/strong><\/p>\n\n\n\n

Uplynulo v\u00edce ne\u017e 40 let, co medic\u00edna \u00fasp\u011b\u0161n\u011b poprv\u00e9 pou\u017eila k transplantaci kmenov\u00e9 bu\u0148ky. V\u011bdci je izolovali z kostn\u00ed d\u0159en\u011b. V\u00fdznamn\u00fdm mezn\u00edkem v oblasti l\u00e9\u010den\u00ed z\u00e1va\u017en\u00fdch onemocn\u011bn\u00ed byl rok 1978 a zji\u0161t\u011bn\u00ed, \u017ee vhodn\u00fdm zdrojem kmenov\u00fdch bun\u011bk je pupe\u010dn\u00edkov\u00e1 krev. N\u00e1sledovalo dal\u0161\u00edch 10 let intenzivn\u00edch v\u00fdzkum\u016f, ne\u017e byla pupe\u010dn\u00edkov\u00e1 krev pou\u017eita k transplantaci. \u00dasp\u011b\u0161nost tohoto postupu potvrzuje fakt, \u017ee od t\u00e9 doby bylo po cel\u00e9m sv\u011bt\u011b provedeno v\u00edce ne\u017e 60 000 transplantac\u00ed pupe\u010dn\u00edkov\u00e9 krve. Pokrok se v\u0161ak nezastavil. V\u011bdci hledaj\u00ed dal\u0161\u00ed zdroje kmenov\u00fdch bun\u011bk a jak nazna\u010duj\u00ed posledn\u00ed v\u00fdzkumy, velk\u00fd potenci\u00e1l m\u00e1 i doned\u00e1vna nepov\u0161imnut\u00e1 tk\u00e1n\u011b placenty. Vzhledem k tomu, \u017ee placenta je p\u0159esn\u011b mezistupn\u011bm mezi d\u00edt\u011btem a matkou, m\u00e1 v\u00fdjime\u010dn\u00e9 imunomodula\u010dn\u00ed vlastnosti, kter\u00e9 jsou velmi \u017e\u00e1dan\u00e9 zejm\u00e9na v budouc\u00ed mo\u017en\u00e9 l\u00e9\u010db\u011b autoimunitn\u00edch onemocn\u011bn\u00ed. Tak\u00e9 proto, \u017ee pr\u016fm\u011brn\u00e1 placenta v\u00e1\u017e\u00ed 500 g, z\u00edsk\u00e1v\u00e1me mnohem v\u011bt\u0161\u00ed po\u010det bun\u011bk, kter\u00e9 mohou b\u00fdt v budoucnu pou\u017eity k l\u00e9\u010db\u011b pacienta.<\/p>\n\n\n\n

V\u00fdzkum na vzestupu<\/strong><\/p>\n\n\n\n

V sou\u010dasnosti prob\u00edh\u00e1 podle \u00fadaj\u016f z registru klinick\u00fdch zkou\u0161ek v\u00edce ne\u017e 20 studi\u00ed, pou\u017e\u00edvaj\u00edc\u00edch kmenov\u00e9 bu\u0148ky z placenty. O\u010dek\u00e1v\u00e1n\u00ed v medic\u00edn\u011b jsou velk\u00e1. Regenera\u010dn\u00ed schopnosti t\u011bchto bun\u011bk byly potvrzeny na klinick\u00fdch zkou\u0161k\u00e1ch p\u0159i l\u00e9\u010db\u011b d\u011btsk\u00e9 mozkov\u00e9 obrny, mozkov\u00e9 mrtvice, infarktu myokardu, po\u0161kozen\u00ed m\u00edchy, jatern\u00ed cirh\u00f3zy i p\u0159i obnov\u011b kostn\u00edch a chrupav\u010dit\u00fdch tk\u00e1n\u00ed. Tlum\u00ed i funkci imunitn\u00edho syst\u00e9mu, co\u017e v\u00fdrazn\u011b pom\u00e1h\u00e1 p\u0159i zm\u00edrn\u011bn\u00ed komplikac\u00ed po transplantaci krvetvorn\u00fdch kmenov\u00fdch bun\u011bk a jin\u00fdch org\u00e1n\u016f. Jsou tak\u00e9 \u00fa\u010dinn\u00e9 p\u0159i l\u00e9\u010db\u011b autoimunitn\u00edch onemocn\u011bn\u00ed, jako jsou revmatoidn\u00ed artritida, roztrou\u0161en\u00e1 skler\u00f3za a Crohnova choroba. Testuje se i vyu\u017eit\u00ed kmenov\u00fdch bun\u011bk z placenty p\u0159i l\u00e9\u010db\u011b kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed jako ischemie nebo arterioskler\u00f3za. Potenci\u00e1l kmenov\u00fdch bun\u011bk z placenty je obrovsk\u00fd a z\u016fst\u00e1v\u00e1 jen ot\u00e1zkou \u010dasu, kdy v\u011bdeck\u00e9 zkoum\u00e1n\u00ed p\u0159inese jejich dal\u0161\u00ed pozitivn\u00ed p\u0159\u00edsp\u011bvek k zachov\u00e1n\u00ed a obnov\u011b zdrav\u00ed.<\/p>\n\n\n\n

Perspektivn\u00ed vyu\u017eit\u00ed v l\u00e9\u010db\u011b onemocn\u011bn\u00ed<\/strong><\/p>\n\n\n\n

Kmenov\u00e9 bu\u0148ky v l\u00e9\u010db\u011b nemoc\u00ed \u2013 Kmenov\u00e9 bu\u0148ky z pupe\u010dn\u00edkov\u00e9 krve maj\u00ed schopnost diferencovat se na r\u016fzn\u00e9 typy bun\u011bk, co\u017e je \u010din\u00ed cenn\u00fdm zdrojem pro l\u00e9\u010dbu nemoc\u00ed. Studie zkoumaj\u00ed jejich vyu\u017eit\u00ed p\u0159i l\u00e9\u010db\u011b leuk\u00e9mi\u00ed, srde\u010dn\u00edch onemocn\u011bn\u00ed, cukrovky, mozkov\u00fdch obrn, ur\u010dit\u00fdch typ\u016f poruch autistick\u00e9ho spektra (nap\u0159. vysokofunk\u010dn\u00ed autismus), typ\u016f ischemick\u00fdch poran\u011bn\u00ed mozku a dal\u0161\u00edch onemocn\u011bn\u00ed.<\/p>\n\n\n\n

Kombinovan\u00e1 terapie \u2013 Zkoum\u00e1 se tak\u00e9 mo\u017enost kombinovat kmenov\u00e9 bu\u0148ky z pupe\u010dn\u00edkov\u00e9 krve s jin\u00fdmi l\u00e9\u010debn\u00fdmi metodami, jako je genov\u00e1 terapie a imunoterapie. Tato kombinace m\u016f\u017ee poskytnout efektivn\u011bj\u0161\u00ed l\u00e9\u010dbu.<\/p>\n\n\n\n

Terapie regenerace tk\u00e1n\u00ed a anti-st\u00e1rnut\u00ed \u2013 Kmenov\u00e9 bu\u0148ky z pupe\u010dn\u00edkov\u00e9 krve se tak\u00e9 zkoumaj\u00ed v oblasti regenerativn\u00ed medic\u00edny a anti-st\u00e1rnut\u00ed. Tyto terapie maj\u00ed potenci\u00e1l zlep\u0161it kvalitu \u017eivota pacient\u016f, zejm\u00e9na v oblasti neurodegenerativn\u00edch onemocn\u011bn\u00ed, oftalmologie, ortopedick\u00fdch probl\u00e9m\u016f a endokrinologick\u00fdch poruch.<\/p>\n\n\n\n

T\u00e9m\u011b\u0159 800 klinick\u00fdch studi\u00ed po cel\u00e9m sv\u011bt\u011b ov\u011b\u0159uje pou\u017eit\u00ed pupe\u010dn\u00edkov\u00e9 krve, tk\u00e1n\u011b pupe\u010dn\u00edku a placenty p\u0159i mnoha onemocn\u011bn\u00edch. Dosavadn\u00ed v\u00fdsledky klinick\u00fdch studi\u00ed a praktick\u00e9 vyu\u017eit\u00ed pupe\u010dn\u00edkov\u00e9 krve potvrzuj\u00ed jej\u00ed spolehlivost a efektivitu v r\u016fzn\u00fdch oblastech medic\u00edny. L\u00e9\u010dba expandovanou pupe\u010dn\u00edkovou krv\u00ed p\u0159edstavuje inovativn\u00ed p\u0159\u00edstup, kter\u00fd kombinuje rychlost hojen\u00ed s vysokou \u00fa\u010dinnost\u00ed. Vzhledem k r\u016fznorod\u00fdm v\u00fdzkumn\u00fdm sm\u011br\u016fm a perspektiv\u00e1m vyu\u017eit\u00ed kmenov\u00fdch bun\u011bk z pupe\u010dn\u00edkov\u00e9 krve a placenty z\u016fst\u00e1v\u00e1 tato oblast jedn\u00edm z nejv\u00fdznamn\u011bj\u0161\u00edch t\u00e9mat v modern\u00ed medic\u00edn\u011b. Odborn\u00edci se shoduj\u00ed na tom, \u017ee d\u016fkladn\u00fd v\u00fdzkum a inovace v t\u00e9to oblasti mohou otev\u0159\u00edt nov\u00e9 mo\u017enosti pro l\u00e9\u010dbu a regeneraci lidsk\u00e9ho t\u011bla.<\/p>\n\n\n\n

Je d\u016fle\u017eit\u00e9 si uv\u011bdomit, \u017ee vyu\u017eit\u00ed pupe\u010dn\u00edkov\u00e9 krve je st\u00e1le v\u00fdzkumnou oblast\u00ed a ne v\u0161echny aplikace jsou ji\u017e klinicky ov\u011b\u0159en\u00e9. P\u0159ed jak\u00fdmkoli rozhodnut\u00edm ohledn\u011b pupe\u010dn\u00edkov\u00e9 krve je vhodn\u00e9 konzultovat se zdravotn\u00edm odborn\u00edkem a zv\u00e1\u017eit aktu\u00e1ln\u00ed stav v\u00fdzkumu a l\u00e9\u010dby.<\/p>\n\n\n\n

— <\/p>\n\n\n\n

<\/p>\n\n\n\n

— <\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

 Trendy p\u0159i vyu\u017e\u00edv\u00e1n\u00ed pupe\u010dn\u00edkov\u00e9 krve V sou\u010dasn\u00e9 dob\u011b je odb\u011br a vyu\u017eit\u00ed pupe\u010dn\u00edkov\u00e9 krve t\u00e9m\u011b\u0159 b\u011b\u017enou prax\u00ed, ale kl\u00ed\u010dov\u00fdm aspektem tohoto procesu je neust\u00e1le se […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":44518,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-47148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/47148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=47148"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/47148\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/44518"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=47148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=47148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}