{"id":50023,"date":"2024-06-20T12:47:22","date_gmt":"2024-06-20T10:47:22","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=50023"},"modified":"2024-06-20T12:47:23","modified_gmt":"2024-06-20T10:47:23","slug":"klic-k-uspesnemu-oplodneni-dukladna-znalost-vajicek","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=50023","title":{"rendered":"Kl\u00ed\u010d k\u00a0\u00fasp\u011b\u0161n\u00e9mu oplodn\u011bn\u00ed? D\u016fkladn\u00e1 znalost vaj\u00ed\u010dek"},"content":{"rendered":"\n

Praha, 20. 6. 2024 \u2013 N\u011bkter\u00e9 reproduk\u010dn\u00ed kliniky si u\u017e bez nich svoji pr\u00e1ci neum\u00ed p\u0159edstavit \u2013 zkoumaj\u00ed v\u00fdvoj lidsk\u00fdch vaj\u00ed\u010dek a embry\u00ed, pom\u00e1haj\u00ed zav\u00e1d\u011bt do praxe nov\u00e9 metody um\u011bl\u00e9ho oplodn\u011bn\u00ed (IVF) a posuzuj\u00ed \u00fasp\u011b\u0161nost t\u011bch st\u00e1vaj\u00edc\u00edch. <\/strong><\/p>\n\n\n\n

\u0158e\u010d je o t\u00fdmech v\u011bdc\u016f, kter\u00e9 jsou sou\u010d\u00e1st\u00ed modern\u00edch center asistovan\u00e9 reprodukce<\/strong>. Pozornost v nich v\u011bdci v\u00a0posledn\u00ed dob\u011b zam\u011b\u0159uj\u00ed zejm\u00e9na na pochopen\u00ed vnit\u0159n\u00ed struktury \u017eensk\u00e9ho vaj\u00ed\u010dka. To, jak vaj\u00ed\u010dko (oocyt) vypad\u00e1 zevnit\u0159, podobn\u011b jako jeho genetika v\u00fdznamn\u011b ovliv\u0148uje \u00fasp\u011b\u0161nost l\u00e9\u010dby neplodnosti.<\/strong><\/p>\n\n\n\n

\u201eLidsk\u00e1 vaj\u00ed\u010dka jsme st\u00e1le je\u0161t\u011b dostate\u010dn\u011b neprozkoumali. Nejv\u00edc zmapovan\u00fd je probl\u00e9m nerovnom\u011brn\u00e9ho rozlo\u017een\u00ed chromozom\u016f, s\u00a0n\u00edm\u017e souvis\u00ed genetick\u00e9 poruchy. Vaj\u00ed\u010dko je ale bu\u0148ka, kter\u00e1 \u017eije a m\u00e1 svoje bun\u011b\u010dn\u00e9 t\u011bl\u00ed\u010dko. I to je pot\u0159eba zkoumat. P\u0159\u00ed\u010dinou neplodnosti toti\u017e m\u016f\u017ee b\u00fdt tak\u00e9 \u0161patn\u00e1 cytoplazma, tedy vnit\u0159n\u00ed prost\u0159ed\u00ed vaj\u00ed\u010dka,\u201c <\/em>popisuje v\u011bdkyn\u011b PharmDr. Zuzana Holubcov\u00e1, kter\u00e1 se dlouhodob\u011b zab\u00fdv\u00e1 studiem v\u00fdvoje oocyt\u016f. Tento v\u00fdzkum zah\u00e1jila b\u011bhem pracovn\u00edho pobytu v\u00a0anglick\u00e9 Cambridge, pot\u00e9 se vr\u00e1tila do \u010cesk\u00e9 republiky a v\u00a0roce 2015 za\u010dala spolupracovat s\u00a0brn\u011bnskou klinikou Reprofit.<\/p>\n\n\n\n

\u201eVaj\u00ed\u010dko sice m\u016f\u017ee vykazovat vn\u011bj\u0161\u00ed znaky oplozen\u00ed, to v\u0161ak nemus\u00ed b\u00fdt \u00fapln\u011b vypov\u00eddaj\u00edc\u00ed. Proto se v\u00a0odd\u011blen\u00ed v\u011bdy a v\u00fdzkumu zam\u011b\u0159ujeme i\u00a0na pochopen\u00ed vnit\u0159n\u00ed struktury vaj\u00ed\u010dka. Pomoc\u00ed speci\u00e1ln\u00edch vysokorozli\u0161ovac\u00edch mikroskop\u016f je s\u00a0kolegy zkoum\u00e1me na \u00farovni nanometr\u016f,\u201c<\/em> popisuje v\u011bdkyn\u011b. <\/p>\n\n\n\n

\u201e<\/em>Na v\u011bt\u0161in\u011b klinik se v\u011bdecky prezentuje pouze laboratorn\u00ed \u010d\u00e1st nebo genetika. Na\u0161e klinika je unik\u00e1tn\u00ed v\u00a0tom, \u017ee m\u00e1 sv\u00e9 vlastn\u00ed odd\u011blen\u00ed v\u011bdy a v\u00fdzkumu,\u201c <\/em>dopl\u0148uje vedouc\u00ed l\u00e9ka\u0159 Reprofitu Brno MUDr. Pavel Otev\u0159el.<\/p>\n\n\n\n

Pr\u00e1v\u011b v\u011bdeck\u00fd v\u00fdzkum a aplikace z\u00edskan\u00fdch poznatk\u016f do praxe jsou jedn\u00edm z\u00a0kl\u00ed\u010d\u016f \u00fasp\u011bchu l\u00e9\u010dby pomoc\u00ed IVF. V\u011bdci v Reprofitu \u00fazce spolupracuj\u00ed s\u00a0embryology, kte\u0159\u00ed d\u00edky nim dok\u00e1\u017eou l\u00e9pe posoudit, zda je vaj\u00ed\u010dko dostate\u010dn\u011b kvalitn\u00ed a zral\u00e9.<\/p>\n\n\n\n

\u201eZjednodu\u0161en\u011b lze \u0159\u00edct, \u017ee vaj\u00ed\u010dko je maminka, kter\u00e1 d\u00edt\u011bti sbal\u00ed sva\u010dinu na cestu, a spermie tat\u00ednek, kter\u00fd ho odveze na autobus. Teprve na v\u00fdlet\u011b se uk\u00e1\u017ee, jestli bez nich d\u00edt\u011b \u2013 tedy embryo \u2013 dok\u00e1\u017ee fungovat samostatn\u011b,\u201c<\/em> vysv\u011btluje PharmDr.\u00a0Holubcov\u00e1. Aby se embrya vyv\u00edjela spr\u00e1vn\u011b, mus\u00ed odborn\u00edci vybrat ta nejkvalitn\u011bj\u0161\u00ed vaj\u00ed\u010dka a spr\u00e1vn\u011b na\u010dasovat jejich oplozen\u00ed. Jak v\u011bdkyn\u011b upozor\u0148uje, kvalita genetick\u00e9 v\u00fdbavy vaj\u00ed\u010dek u \u017een s p\u0159ib\u00fdvaj\u00edc\u00edmi roky kles\u00e1 a s\u00a0n\u00ed i \u00fasp\u011b\u0161nost IVF.<\/p>\n\n\n\n

\u201eNen\u00ed to tak, \u017ee se vzbud\u00edm ve 34\u00a0letech a \u0159eknu si \u2013 jsem zdrav\u00e1, v\u0161e je v\u00a0pohod\u011b a te\u010f budu m\u00edt d\u00edt\u011b. Ide\u00e1ln\u00ed v\u011bk na t\u011bhotenstv\u00ed je kolem 25 let,\u201c<\/em> \u0159\u00edk\u00e1 PharmDr. Holubcov\u00e1. Vnit\u0159n\u00ed prost\u0159ed\u00ed vaj\u00ed\u010dka ale podle n\u00ed m\u016f\u017ee b\u00fdt \u0161patn\u00e9 v\u00a0jak\u00e9mkoli v\u011bku \u017eeny. \u201eNad t\u00edm, pro\u010d se\u00a0p\u0159\u00edpadn\u011b oplozen\u00ed nepovedlo, je proto t\u0159eba p\u0159em\u00fd\u0161let v\u00a0\u0161ir\u0161\u00edch souvislostech,\u201c <\/em>zd\u016fraz\u0148uje v\u011bdkyn\u011b.<\/p>\n\n\n\n

Spolupr\u00e1ci s\u00a0v\u011bdci reproduk\u010dn\u00ed kliniky oce\u0148uj\u00ed. Pom\u00e1h\u00e1 jim monitorovat \u00fasp\u011b\u0161nost vyu\u017e\u00edvan\u00fdch metod a neust\u00e1le se zdokonalovat. \u201eU\u017e v\u00a0minulosti tato spolupr\u00e1ce na na\u0161\u00ed klinice p\u0159isp\u011bla k\u00a0zaveden\u00ed n\u011bkter\u00fdch nov\u00fdch metod, a zv\u00fd\u0161ila tak \u0161anci na oplodn\u011bn\u00ed i u pacient\u016f s ur\u010dit\u00fdmi specifick\u00fdmi pot\u00ed\u017eemi, nap\u0159\u00edklad s\u00a0problematick\u00fdm dozr\u00e1v\u00e1n\u00edm vaj\u00ed\u010dek. V\u00a0l\u00e9\u010db\u011b pacient\u016f je tak velk\u00fdm p\u0159\u00ednosem,\u201c <\/em>vysv\u011btluje Mgr. So\u0148a Kloudov\u00e1, vedouc\u00ed laborato\u0159\u00ed brn\u011bnsk\u00e9 kliniky Reprofit. \u201ePr\u00e1ce v\u00a0dob\u0159e funguj\u00edc\u00ed embryologick\u00e9 laborato\u0159i je do zna\u010dn\u00e9 m\u00edry rutinn\u00ed. D\u00edky v\u011bdeck\u00fdm t\u00fdm\u016fm si nejenom v\u00a0Brn\u011b, ale i na na\u0161\u00ed klinice v\u00a0Ostrav\u011b v\u00fdznamn\u011b roz\u0161i\u0159ujeme obzory,\u201c<\/em> dod\u00e1v\u00e1.<\/p>\n\n\n\n

O PharmDr. Zuzan\u011b Holubcov\u00e9, Ph.D.:<\/strong><\/p>\n\n\n\n

PharmDr. Zuzana Holubcov\u00e1 m\u00e1 rozs\u00e1hl\u00e9 zku\u0161enosti z v\u00fdzkumu v oboru reproduk\u010dn\u00ed medic\u00edny. Titul Ph.D. obdr\u017eela za pr\u00e1ci na v\u00fdzkumu genetick\u00e9 nestability lidsk\u00fdch embryon\u00e1ln\u00edch kmenov\u00fdch bun\u011bk. Jako postgradu\u00e1ln\u00ed v\u00fdzkumn\u00edk vypracovala v Cambridge nov\u00e9 postupy umo\u017e\u0148uj\u00edc\u00ed studium v\u00fdvoje lidsk\u00fdch vaj\u00ed\u010dek. Jej\u00ed v\u00fdzkumn\u00e1 pr\u00e1ce, kter\u00e1 mimo jin\u00e9 objasnila p\u0159\u00ed\u010diny genetick\u00fdch poruch lidsk\u00fdch vaj\u00ed\u010dek, byla publikov\u00e1na ve \u0161pi\u010dkov\u00fdch v\u011bdeck\u00fdch \u010dasopisech. PharmDr. Zuzana Holubcov\u00e1 byla tak\u00e9 ocen\u011bna presti\u017en\u00ed Basic Science Award ud\u011blovanou evropskou embryologickou spole\u010dnost\u00ed ESHRE (European Society for Human Reproduction and Embryology) a cenou pro origin\u00e1ln\u00ed v\u011bdeck\u00e9 projekty Neuron Impulsy za rok 2016, obor Medic\u00edna.<\/p>\n","protected":false},"excerpt":{"rendered":"

Praha, 20. 6. 2024 \u2013 N\u011bkter\u00e9 reproduk\u010dn\u00ed kliniky si u\u017e bez nich svoji pr\u00e1ci neum\u00ed p\u0159edstavit \u2013 zkoumaj\u00ed v\u00fdvoj lidsk\u00fdch vaj\u00ed\u010dek a embry\u00ed, pom\u00e1haj\u00ed zav\u00e1d\u011bt […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14161,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-50023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/50023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=50023"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/50023\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14161"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=50023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=50023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=50023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}