Fakultn\u00ed nemocnice Olomouc z\u0159\u00eddila mozkovou banku, ve kter\u00e9 budou uchov\u00e1v\u00e1ny vzorky mozkov\u00e9 tk\u00e1n\u011b darovan\u00e9 zejm\u00e9na pacienty s neurodegenerativn\u00edmi onemocn\u011bn\u00edmi, jako jsou nap\u0159\u00edklad Parkinsonova nebo Alzheimerova nemoc. Tento po \u00famrt\u00ed v r\u00e1mci pitvy odebran\u00fd biologick\u00fd materi\u00e1l poslou\u017e\u00ed v\u011bdc\u016fm p\u0159i v\u00fdzkumu z\u00e1va\u017en\u00fdch nemoc\u00ed mozku. P\u0159\u00ed\u010diny a podstatu rozvoje t\u011bchto chorob se nepoda\u0159ilo dosud zcela vysv\u011btlit. St\u00e1le neexistuje \u00fa\u010dinn\u00e1 l\u00e9\u010dba.<\/p>\n\n\n\n
\u201eNavazujeme na zhruba patn\u00e1ctiletou klinickou a patologickou \u010dinnost v brainbankingu, kterou na\u0161e klinika a \u00dastav klinick\u00e9 a molekul\u00e1rn\u00ed patologie prakticky provozuj\u00ed ji\u017e od roku 2009, p\u0159edev\u0161\u00edm z\u00e1sluhou profesorky Kate\u0159iny Men\u0161\u00edkov\u00e9 a doktorky Lucie Tu\u010dkov\u00e9, tehdy jako v\u016fbec prvn\u00ed v r\u00e1mci \u010cesk\u00e9 republiky,\u201c pouk\u00e1zal p\u0159ednosta Neurologick\u00e9 kliniky FN Olomouc Petr Ka\u0148ovsk\u00fd.<\/p>\n\n\n\n
Olomouck\u00e9 odborn\u00edky pozd\u011bji inspirovala n\u00e1v\u0161t\u011bva lond\u00fdnsk\u00e9 mozkov\u00e9 banky, kde vid\u011bli v\u00fdsledky pr\u00e1ce tamn\u00edch v\u011bdc\u016f v oblasti sb\u011bru tk\u00e1n\u00ed a v\u00fdzkumu neurodegenerativn\u00edch onemocn\u011bn\u00ed.<\/p>\n\n\n\n
\u201ePo n\u00e1vratu jsme zavedli stejn\u00fd syst\u00e9m i u n\u00e1s. Nyn\u00ed tedy tato \u010dinnost z\u00edsk\u00e1v\u00e1 ofici\u00e1ln\u00ed status v n\u00e1vaznosti na nov\u011b po\u0159\u00edzen\u00e9 \u0161pi\u010dkov\u00e9 vybaven\u00ed, kter\u00e9 n\u00e1s posouv\u00e1 na \u00farove\u0148 p\u0159edn\u00edch center nap\u0159\u00edklad pr\u00e1v\u011b v Lond\u00fdn\u011b, V\u00eddni, Var\u0161av\u011b \u010di Torontu,\u201c popisoval profesor Ka\u0148ovsk\u00fd.<\/p>\n\n\n\n
Mozkov\u00e1 banka zaji\u0161\u0165uje standardizovan\u00fd postup p\u0159i odb\u011bru, vy\u0161et\u0159en\u00ed a skladov\u00e1n\u00ed biologick\u00e9ho materi\u00e1lu, co\u017e jsou nezbytn\u00e9 podm\u00ednky \u00fasp\u011b\u0161n\u00e9ho v\u00fdzkumu v oblasti neurodegenerativn\u00edch onemocn\u011bn\u00ed. Je druhou v \u010cesk\u00e9 republice. Prvn\u00ed ofici\u00e1ln\u00ed vznikla ve Fakultn\u00ed Thomayerov\u011b nemocnici v Praze.<\/p>\n\n\n\n
Ob\u011b banky podle olomouck\u00fdch expert\u016f ji\u017e spolupracuj\u00ed. Vz\u00e1jemn\u00e9 sd\u00edlen\u00ed v\u00fdsledk\u016f v\u00fdzkumu je z\u00e1sadn\u00ed pro zlep\u0161ov\u00e1n\u00ed diagnostiky neurodegenerativn\u00edch onemocn\u011bn\u00ed a pro pochopen\u00ed z\u00e1kladn\u00edch mechanism\u016f jejich rozvoje a v\u00fdvoj nov\u00fdch l\u00e9k\u016f do budoucna.<\/p>\n\n\n\n
Ur\u010den\u00ed spr\u00e1vn\u00e9 diagn\u00f3zy b\u011bhem \u017eivota pacienta je podle expert\u016f v p\u0159\u00edpad\u011b neurodegenerativn\u00edch onemocn\u011bn\u00ed v sou\u010dasn\u00e9 dob\u011b st\u00e1le velmi obt\u00ed\u017en\u00e9.<\/p>\n\n\n\n
\u201eA\u017e ve dvaceti procentech p\u0159\u00edpad\u016f je stanovena klinick\u00e1 diagn\u00f3za nespr\u00e1vn\u011b, tedy je nap\u0159\u00edklad diagnostikov\u00e1na Parkinsonova nemoc, p\u0159esto\u017ee m\u011bl pacient \u00fapln\u011b jin\u00e9 neurodegenerativn\u00ed onemocn\u011bn\u00ed nebo kombinaci r\u016fzn\u00fdch forem neurodegenerace,\u201c vysv\u011btloval p\u0159ednosta kliniky.<\/p>\n\n\n\n
Definitivn\u00ed diagn\u00f3zu, tedy jak\u00fdm typem onemocn\u011bn\u00ed pacient skute\u010dn\u011b trp\u011bl, je podle n\u011bj mo\u017en\u00e9 stanovit a\u017e neuropatologick\u00fdm vy\u0161et\u0159en\u00edm mozkov\u00e9 tk\u00e1n\u011b.<\/p>\n\n\n\n
\u201eDetailn\u00ed zkoum\u00e1n\u00ed mozkov\u00e9 tk\u00e1n\u011b darovan\u00e9 pacienty, kte\u0159\u00ed trp\u011bli t\u011bmito onemocn\u011bn\u00edmi, tak m\u00e1 z\u00e1sadn\u00ed v\u00fdznam pro pochopen\u00ed patologick\u00fdch d\u011bj\u016f odehr\u00e1vaj\u00edc\u00edch se v posti\u017een\u00e9m mozku a pro v\u00fdvoj \u00fa\u010dinn\u00e9 l\u00e9\u010dby,\u201c vysv\u011btlil p\u0159ednosta Neurologick\u00e9 kliniky.<\/p>\n\n\n\n
Darovat mohou i zdrav\u00ed<\/p>\n\n\n\n
Biologick\u00fd materi\u00e1l uchov\u00e1van\u00fd a d\u00e1le zkouman\u00fd v mozkov\u00e9 bance je z\u00edsk\u00e1v\u00e1n po \u00famrt\u00ed pacienta odb\u011brem v r\u00e1mci pitvy. Odb\u011br a vy\u0161et\u0159en\u00ed mozkov\u00e9 tk\u00e1n\u011b, stejn\u011b jako jej\u00ed archivace a n\u00e1sledn\u00fd v\u00fdzkum podle olomouck\u00fdch specialist\u016f prob\u00edhaj\u00ed v souladu s etick\u00fdmi standardy a s p\u0159edchoz\u00edm souhlasem zem\u0159el\u00e9ho pacienta nebo osob jemu bl\u00edzk\u00fdch.<\/p>\n\n\n\n
\u201eDarov\u00e1n\u00ed mozku znamen\u00e1, \u017ee se pacient rozhodne v\u011bnovat po \u00famrt\u00ed mozek pro pot\u0159eby v\u00fdzkumu. Za t\u00edmto \u00fa\u010delem podep\u00ed\u0161e s o\u0161et\u0159uj\u00edc\u00edm l\u00e9ka\u0159em Souhlas s uchov\u00e1n\u00edm a vyu\u017eit\u00edm mozkov\u00e9 tk\u00e1n\u011b pro pot\u0159eby v\u00fdzkumu. Pokud d\u00e1rce nen\u00ed schopen vyplnit a podepsat informovan\u00fd souhlas, m\u016f\u017ee tak u\u010dinit jeho nejbli\u017e\u0161\u00ed p\u0159\u00edbuzn\u00fd. Tento souhlas je ulo\u017een ve zdravotnick\u00e9 dokumentaci pacienta a v mozkov\u00e9 bance,\u201c objasnil p\u0159ednosta \u00dastavu klinick\u00e9 a molekul\u00e1rn\u00ed patologie FN Olomouc Jan Bouchal.<\/p>\n\n\n\n
Pro zaji\u0161t\u011bn\u00ed integrity mozkov\u00e9 tk\u00e1n\u011b je d\u016fle\u017eit\u00e9, aby byla mezi \u00famrt\u00edm a odb\u011brem mozku co nejkrat\u0161\u00ed \u010dasov\u00e1 prodleva. Mozkov\u00e1 tk\u00e1\u0148 je nejd\u0159\u00edve d\u016fkladn\u011b vy\u0161et\u0159ena zku\u0161en\u00fdm neuropatologem, \u010d\u00e1st mozku je p\u0159itom pou\u017eita ke stanoven\u00ed definitivn\u00ed diagn\u00f3zy neurologick\u00e9ho onemocn\u011bn\u00ed.<\/p>\n\n\n\n
\u201eDal\u0161\u00ed vzorky jsou uchov\u00e1ny v mrazic\u00edm boxu p\u0159i teplot\u011b m\u00ednus osmdes\u00e1t stup\u0148\u016f Celsia a jin\u00e9 jsou fixov\u00e1ny ve formal\u00ednu. Oba konzerva\u010dn\u00ed postupy umo\u017en\u00ed prov\u00e1d\u011bn\u00ed neurov\u011bdn\u00edho v\u00fdzkumu mnoho let po jejich ulo\u017een\u00ed,\u201c p\u0159ibl\u00ed\u017eil docent Bouchal.<\/p>\n\n\n\n
Pro darov\u00e1n\u00ed mozku pro v\u011bdeck\u00e9 \u00fa\u010dely se mohou rozhodnout i lid\u00e9, kte\u0159\u00ed netrp\u00ed neurodegenerativn\u00edm nebo jin\u00fdm z\u00e1va\u017en\u00fdm onemocn\u011bn\u00edm mozku.<\/p>\n\n\n\n
Tk\u00e1n\u011b darovan\u00e9 lidmi bez neurologick\u00e9ho onemocn\u011bn\u00ed jsou podle olomouck\u00fdch specialist\u016f velmi cenn\u00e9, proto\u017ee umo\u017e\u0148uj\u00ed v\u011bdc\u016fm porozum\u011bn\u00ed a srovn\u00e1n\u00ed vzhledu a fungov\u00e1n\u00ed zdrav\u00e9ho mozku s mozkem posti\u017een\u00fdm neurodegenerativn\u00edm onemocn\u011bn\u00edm.<\/p>\n\n\n\n
Co je \u201eMozkov\u00e1 banka\u201c<\/p>\n\n\n\n
Mozkov\u00e1 banka je za\u0159\u00edzen\u00ed, v kter\u00e9m jsou uchov\u00e1v\u00e1ny vzorky mozkov\u00e9 tk\u00e1n\u011b darovan\u00e9 pacienty s neurodegenerativn\u00edmi onemocn\u011bn\u00edmi. Tato zahrnuj\u00ed nej\u010dast\u011bji Parkinsonovu nemoc, Alzheimerovu nemoc, multisyst\u00e9movou atrofii, progresivn\u00ed supranukle\u00e1rn\u00ed paral\u00fdzu a dal\u0161\u00ed onemocn\u011bn\u00ed projevuj\u00edc\u00ed parkinsonsk\u00fdm syndromem nebo demenc\u00ed.<\/p>\n\n\n\n
Archivovan\u00fd materi\u00e1l m\u016f\u017ee n\u00e1sledn\u011b slou\u017eit k dal\u0161\u00edm anal\u00fdz\u00e1m na bun\u011b\u010dn\u00e9 a molekul\u00e1rn\u00ed \u00farovni. V p\u0159\u00edpad\u011b prov\u00e1d\u011bn\u00ed genetick\u00e9ho vy\u0161et\u0159en\u00ed bude v\u017edy nezbytn\u00fd explicitn\u00ed souhlas Etick\u00e9 komise Fakultn\u00ed nemocnice Olomouc.<\/p>\n\n\n\n
Podrobn\u00e9 informace a formul\u00e1\u0159e souhlas\u016f pro d\u00e1rce i osoby bl\u00edzk\u00e9 jsou k dispozici na str\u00e1nk\u00e1ch mozkov\u00e9 banky: https:\/\/mozkovabanka.fnol.cz\/<\/a><\/p>\n\n\n\n Darovat t\u011blo pro medic\u00ednsk\u00e9 \u00fa\u010dely<\/p>\n\n\n\n Lid\u00e9 mohou poskytnout sv\u00e9 t\u011blo pro v\u011bdeck\u00e9 a v\u00fdukov\u00e9 \u00fa\u010dely. U\u0161lechtil\u00e9 rozhodnut\u00ed dobrovoln\u00fdch d\u00e1rc\u016f umo\u017en\u00ed nap\u0159\u00edklad zabezpe\u010den\u00ed praktick\u00e9 v\u00fduky budouc\u00edch l\u00e9ka\u0159\u016f, pro kter\u00e9 jsou anatomick\u00e9 znalosti stavby lidsk\u00e9ho t\u011bla nezbytn\u00e9.<\/p>\n\n\n\n Z\u00e1jemci se mohou obr\u00e1tit nap\u0159\u00edklad na \u00dastav norm\u00e1ln\u00ed anatomie L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Palack\u00e9ho. V\u00edce informac\u00ed na webu \u00dastavu norm\u00e1ln\u00ed anatomie.<\/p>\n\n\n\n Daniela Tauberov\u00e1<\/p>\n\n\n\n Olomouck\u00fd den\u00edk<\/p>\n\n\n\n https:\/\/olomoucky.denik.cz<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Fakultn\u00ed nemocnice Olomouc z\u0159\u00eddila mozkovou banku, ve kter\u00e9 budou uchov\u00e1v\u00e1ny vzorky mozkov\u00e9 tk\u00e1n\u011b darovan\u00e9 zejm\u00e9na pacienty s neurodegenerativn\u00edmi onemocn\u011bn\u00edmi, jako jsou nap\u0159\u00edklad Parkinsonova nebo Alzheimerova […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":1875,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-52135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52135"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52135\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/1875"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}