V \u010cesku odstartovala p\u0159elomov\u00e1 studie<\/p>\n\n\n\n
Praha, 9. 10. 2024 \u2013 V \u010cesku odstartovala klinick\u00e1 studie, kter\u00e1 zkoum\u00e1, zda je mo\u017en\u00e9 naj\u00edt n\u00e1dor slinivky b\u0159i\u0161n\u00ed v\u010das. \u0158e\u0161\u00ed citlivost testu, kter\u00fd by m\u011bl z krve pacienta odhalit p\u0159\u00edpadn\u00e9 p\u0159edn\u00e1dorov\u00e9 zm\u011bny. Pokud se \u00fa\u010dinnost tzv. lipidomick\u00e9ho testu prok\u00e1\u017ee, p\u016fjde o z\u00e1sadn\u00ed pr\u016flom. Test by se pak toti\u017e mohl st\u00e1t n\u00e1strojem pro screening n\u00e1dorov\u00fdch onemocn\u011bn\u00ed slinivky b\u0159i\u0161n\u00ed. Na studii spolupracuje spole\u010dnost Lipidica s gastroenterology a onkology. Kl\u00ed\u010dov\u00fdmi partnery jsou <\/strong>Fakultn\u00ed nemocnice Olomouc a Masaryk\u016fv onkologick\u00fd \u00fastav. Do studie by se m\u011blo celkem zapojit 15 center po cel\u00e9 republice.<\/strong><\/p>\n\n\n\n Podle expert\u016f z \u010cesk\u00e9 gastroenterologick\u00e9 spole\u010dnosti (\u010cGS) ro\u010dn\u011b onemocn\u00ed rakovinou slinivky b\u0159i\u0161n\u00ed (pankreatu) p\u0159ibli\u017en\u011b 2 400 lid\u00ed, t\u00e9m\u011b\u0159 2 200 j\u00ed za stejn\u00e9 obdob\u00ed podlehne a odborn\u00edci p\u0159edpokl\u00e1daj\u00ed, \u017ee v roce 2030 bude tato nemoc druhou nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed na n\u00e1dorov\u00e1 onemocn\u011bn\u00ed. \u201e<\/em>Rakovina slinivky b\u0159i\u0161n\u00ed pat\u0159\u00ed mezi nejagresivn\u011bj\u0161\u00ed n\u00e1dory v\u016fbec \u2013 do posledn\u00ed chv\u00edle je bez p\u0159\u00edznak\u016f, p\u0159esto\u017ee se vyv\u00edj\u00ed v\u00edce ne\u017e 10 let. Kdy\u017e za\u010dnou pot\u00ed\u017ee, je u\u017e na l\u00e9\u010dbu obvykle pozd\u011b. Jedinou nad\u011bj\u00ed na vyl\u00e9\u010den\u00ed je operace, ke kter\u00e9 v\u0161ak dosp\u011bje jen asi 20 % nemocn\u00fdch. Zbytek pacient\u016f se bohu\u017eel nach\u00e1z\u00ed ve stadi\u00edch, kdy se jim sna\u017e\u00edme prodlou\u017eit \u017eivot v co nejlep\u0161\u00ed kvalit\u011b,\u201c<\/em> \u0159\u00edk\u00e1 prof. MUDr. Ond\u0159ej Urban, Ph.D., p\u0159ednosta II. intern\u00ed kliniky gastroenterologick\u00e9 a geriatrick\u00e9 Fakultn\u00ed nemocnice Olomouc. Zat\u00edmco u pacient\u016f s pokro\u010dil\u00fdm stadiem rakoviny slinivky se pr\u016fm\u011brn\u00e1 doba do\u017eit\u00ed pohybuje kolem 1,5 roku, v\u010dasn\u011b odhalen\u00ed mohou \u017e\u00edt a\u017e \u0161estkr\u00e1t d\u00e9le. \u201eV\u00edme, \u017ee u t\u011bch, kte\u0159\u00ed n\u00e1dor slinivky b\u0159i\u0161n\u00ed maj\u00ed, se li\u0161\u00ed mno\u017estv\u00ed a slo\u017een\u00ed lipid\u016f. Pr\u00e1v\u011b prob\u00edhaj\u00edc\u00ed studie uk\u00e1\u017ee, zda bude test schopen z krve odhalit zm\u011bny v lipidech u rizikov\u00fdch jedinc\u016f, kte\u0159\u00ed se c\u00edt\u00ed b\u00fdt zdrav\u00ed, a p\u0159esto se u\u017e v jejich t\u011ble n\u011bco d\u011bje<\/em>,\u201c vysv\u011btluje prof. Urban.<\/p>\n\n\n\n Pokud se \u00fa\u010dinnost testu prok\u00e1\u017ee, p\u016fjde podle prim\u00e1\u0159e Gastroenterologick\u00e9ho odd\u011blen\u00ed Masarykova onkologick\u00e9ho \u00fastavu doc. MUDr. Jana Trny, Ph.D., o naprost\u00fd p\u0159elom v l\u00e9\u010db\u011b rakoviny slinivky b\u0159i\u0161n\u00ed. \u201eV sou\u010dasn\u00e9 dob\u011b nem\u00e1me moc mo\u017enost\u00ed, jak vyhledat lidi, kter\u00fdm hroz\u00ed, \u017ee nemoc dostanou. A vzhledem k finan\u010dn\u00ed, kapacitn\u00ed a medic\u00ednsk\u00e9 n\u00e1ro\u010dnosti nem\u016f\u017eeme prov\u00e1d\u011bt specializovan\u00e9 preventivn\u00ed vy\u0161et\u0159en\u00ed v\u0161em. S odb\u011brem krve je to ale jinak. Desetilet\u00ed tou\u017e\u00edme po tom, abychom byli schopni naj\u00edt nemoc v\u010das \u2013 zrovna u t\u00e9to nemoci je to naprosto kl\u00ed\u010dov\u00e9,\u201c<\/em> \u0159\u00edk\u00e1 prim. Trna. P\u0159edn\u00e1dorov\u00e9 zm\u011bny nebo rakovinu v ran\u00e9 f\u00e1zi nyn\u00ed pom\u00e1h\u00e1 odhalit program v\u010dasn\u00e9ho z\u00e1chytu karcinomu pankreatu. V jeho r\u00e1mci gastroenterologov\u00e9 \u00fazce spolupracuj\u00ed<\/p>\n\n\n\n s klinick\u00fdmi genetiky a s radiology, kte\u0159\u00ed prov\u00e1d\u011bj\u00ed dal\u0161\u00ed specializovan\u00e1 vy\u0161et\u0159en\u00ed, nap\u0159. magnetickou rezonanci.<\/p>\n\n\n\n Screeningov\u00fd program je v sou\u010dasnosti ur\u010den pouze lidem, jejich\u017e celo\u017eivotn\u00ed riziko tohoto druhu rakoviny je vy\u0161\u0161\u00ed ne\u017e 5 %. \u201eV nov\u011b z\u0159izovan\u00fdch centrech <\/em>vysoce specializovan\u00e9 p\u00e9\u010de pro digestivn\u00ed endoskopii, kam pat\u0159\u00ed i na\u0161e pracovi\u0161t\u011b, podstupuj\u00ed rizikov\u00e9 osoby pravideln\u00e9 vy\u0161et\u0159en\u00ed slinivky b\u0159i\u0161n\u00ed magnetickou rezonanc\u00ed a endoskopickou ultrasonografi\u00ed,\u201c <\/em>\u0159\u00edk\u00e1doc. MUDr. Ilja Tachec\u00ed, Ph.D., p\u0159edseda \u010cGS a p\u0159ednosta II. intern\u00ed gastroenterologick\u00e9 kliniky LF UK a FN Hradec Kr\u00e1lov\u00e9. Mezi rizikov\u00e9 jedince pat\u0159\u00ed ti, kte\u0159\u00ed maj\u00ed d\u011bdi\u010dnou formu chronick\u00e9ho z\u00e1n\u011btu slinivky b\u0159i\u0161n\u00ed nebo maj\u00ed dva a v\u00edce p\u0159\u00edm\u00fdch p\u0159\u00edbuzn\u00fdch s rakovinou pankreatu. Ohro\u017eeni jsou tak\u00e9 nositel\u00e9 ur\u010dit\u00fdch genetick\u00fdch mutac\u00ed \u2013 nap\u0159\u00edklad mutace v genu BRCA1 a BRCA2, kter\u00e9 jsou z\u00e1rove\u0148 p\u016fvodcem n\u00e1dor\u016f prs\u016f a vaje\u010dn\u00edk\u016f.<\/p>\n\n\n\n \u201eRizikov\u00e9 osoby k n\u00e1m chod\u00ed na kontroly pravideln\u011b jednou ro\u010dn\u011b. V r\u00e1mci t\u00e9to studie jim nav\u00edc odebereme, s jejich informovan\u00fdm souhlasem, krev, ji\u017e pak ve form\u011b plazmy pos\u00edl\u00e1me do laborato\u0159e Lipidica,\u201c<\/em> dod\u00e1v\u00e1 prof. Urban. Studie tak zkoum\u00e1 krev od rizikov\u00fdch jedinc\u016f, kte\u0159\u00ed jsou zat\u00edm zdrav\u00ed, i od t\u011bch, kte\u0159\u00ed u\u017e n\u00e1dor maj\u00ed, ale mal\u00fd \u2013 operabiln\u00ed. \u201eDosavadn\u00ed diagnostick\u00e9 metody jsou sice velmi \u00fa\u010dinn\u00e9, ale z\u00e1rove\u0148 n\u00e1kladn\u00e9 a pro pacienta nep\u0159\u00edjemn\u00e9, test na z\u00e1klad\u011b b\u011b\u017en\u00e9ho odb\u011bru krve bude pro klinickou praxi velk\u00fdm p\u0159\u00ednosem. N\u00e1\u0161 lipidomick\u00fd test LDPC je zalo\u017een na patentov\u011b chr\u00e1n\u011bn\u00e9 metodice vyvinut\u00e9 na Univerzit\u011b Pardubice a kombinuje poznatky analytick\u00e9 chemie, biostatistiky a dal\u0161\u00edch v\u011bdn\u00edch obor\u016f<\/em>,\u201c dod\u00e1v\u00e1 Ing. Karol\u00edna Ka\u0161parov\u00e1, \u0159editelka firmy Lipidica, kter\u00e1 je tak\u00e9 akreditovanou zdravotnickou laborato\u0159\u00ed.<\/p>\n\n\n\n Studie odstartovala letos a m\u011bla by skon\u010dit v roce 2027, projde j\u00ed v\u00edce ne\u017e 400 \u00fa\u010dastn\u00edk\u016f. Pokud se specificita a citlivost testu potvrd\u00ed, potrv\u00e1 podle odborn\u00edk\u016f je\u0161t\u011b n\u011bjak\u00fd \u010das, ne\u017e se test stane sou\u010d\u00e1st\u00ed standardn\u00ed p\u00e9\u010de. A ne\u017e bude jasn\u00e9, zda jej proplat\u00ed zdravotn\u00ed poji\u0161\u0165ovny, nebo si jej lid\u00e9 budou hradit sami. U\u017e nyn\u00ed v\u0161ak v\u00fdrobce deklaruje, \u017ee by cena nem\u011bla p\u0159es\u00e1hnout n\u00edzk\u00e9 tis\u00edce korun.<\/p>\n","protected":false},"excerpt":{"rendered":" V \u010cesku odstartovala p\u0159elomov\u00e1 studie Praha, 9. 10. 2024 \u2013 V \u010cesku odstartovala klinick\u00e1 studie, kter\u00e1 zkoum\u00e1, zda je mo\u017en\u00e9 naj\u00edt n\u00e1dor slinivky b\u0159i\u0161n\u00ed v\u010das. \u0158e\u0161\u00ed citlivost […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":50140,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-52351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52351"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52351\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/50140"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}