{"id":52993,"date":"2024-11-09T13:01:13","date_gmt":"2024-11-09T12:01:13","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=52993"},"modified":"2024-11-09T13:01:27","modified_gmt":"2024-11-09T12:01:27","slug":"halo-telefone-mam-parkinsona","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=52993","title":{"rendered":"Hal\u00f3 telefone, m\u00e1m \u201eparkinsona\u201c?"},"content":{"rendered":"\n<p><em>Unik\u00e1tn\u00ed aplikace rozpozn\u00e1 onemocn\u011bn\u00ed z&nbsp;nahr\u00e1vky hovoru<\/em><\/p>\n\n\n\n<p><strong>Praha, 7. 11. 2024 \u2013 P\u00e1r minut telefonn\u00edho hovoru \u2013 tolik sta\u010d\u00ed unik\u00e1tn\u00ed \u010desk\u00e9 aplikaci k tomu, aby rozpoznala po\u010d\u00ednaj\u00edc\u00ed Parkinsonovu nemoc. Speci\u00e1ln\u00ed software analyzuje b\u011bhem rozhovoru \u0159e\u010d volaj\u00edc\u00edho a dok\u00e1\u017ee p\u0159itom odhalit i nepatrn\u00e9 zm\u011bny v hlase, kter\u00e9 p\u0159edznamen\u00e1vaj\u00ed n\u00e1stup choroby. Na v\u00fdvoji aplikace pracuje t\u00fdm v\u011bdc\u016f a l\u00e9ka\u0159\u016f z N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum, 1. l\u00e9ka\u0159sk\u00e9 fakulty UK a Fakulty elektrotechnick\u00e9 \u010cVUT. Jejich objev by mohl pomoci s&nbsp;v\u010dasnou diagnostikou onemocn\u011bn\u00ed, kter\u00e1 je u Parkinsonovy nemoci z\u00e1sadn\u00ed. Pokud se chorobu poda\u0159\u00ed zachytit v&nbsp;ran\u00e9m stadiu, mohou l\u00e9ka\u0159i nasadit c\u00edlenou terapii, kter\u00e1 um\u00ed postup jinak nevyl\u00e9\u010diteln\u00e9ho onemocn\u011bn\u00ed zpomalit.<\/strong><\/p>\n\n\n\n<p>\u201e<em>Porucha \u0159e\u010di je jedn\u00edm z&nbsp;prvn\u00edch projev\u016f Parkinsonovy nemoci. Spole\u010dn\u011b s&nbsp;kolegy jsme se proto pokusili vyvinout mobiln\u00ed aplikaci, kter\u00e1 by dok\u00e1zala probl\u00e9my odhalit na z\u00e1klad\u011b anal\u00fdzy uskute\u010dn\u011bn\u00fdch telefonn\u00edch hovor\u016f,\u201c <\/em>popisuje doc. MUDr. Petr Du\u0161ek, Ph.D., z Neurologick\u00e9 kliniky 1.&nbsp;LF UK a VFN v&nbsp;Praze, \u010dlen N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum Neur-IN.<\/p>\n\n\n\n<p>Do studie odborn\u00edci zapojili p\u0159es 70 \u00fa\u010dastn\u00edk\u016f \u2013 krom\u011b lid\u00ed s&nbsp;po\u010d\u00ednaj\u00edc\u00ed Parkinsonovou nemoc\u00ed sledovali tak\u00e9 pacienty, kte\u0159\u00ed trp\u00ed takzvanou poruchou chov\u00e1n\u00ed v&nbsp;REM sp\u00e1nku. Pr\u00e1v\u011b ta toti\u017e b\u00fdv\u00e1 prvn\u00edm p\u0159\u00edznakem nastupuj\u00edc\u00edho neurodegenerativn\u00edho onemocn\u011bn\u00ed. <em>\u201eU pacient\u016f jsme monitorovali dva typy aktivit. Pokud ud\u011blili souhlas, aplikace analyzovala jejich uskute\u010dn\u011bn\u00e9 telefonn\u00ed hovory. Uk\u00e1zalo se, \u017ee ke spr\u00e1vn\u00e9mu vyhodnocen\u00ed sta\u010d\u00ed, aby \u010dlov\u011bk volal p\u0159ibli\u017en\u011b 18 minut, co\u017e odpov\u00edd\u00e1 nap\u0159\u00edklad dev\u00edti kr\u00e1tk\u00fdm hovor\u016fm s&nbsp;p\u0159\u00e1teli nebo rodinou. Z\u00e1rove\u0148 m\u011bli \u00fa\u010dastn\u00edci za \u00fakol p\u0159e\u010d\u00edst v&nbsp;aplikaci vybran\u00e9 pas\u00e1\u017ee textu, p\u0159i\u010dem\u017e poruchu aplikace spolehliv\u011b rozpoznala po zhruba 120&nbsp;slovech,\u201c<\/em> popisuje doc. Du\u0161ek. D\u00edky tomu mohli v\u011bdci porovn\u00e1vat rozd\u00edly v&nbsp;\u0159e\u010di za r\u016fzn\u00fdch podm\u00ednek \u2013 jinak se toti\u017e obt\u00ed\u017ee projevuj\u00ed, pokud \u010dlov\u011bk mluv\u00ed nenucen\u011b spatra, a jinak, kdy\u017e m\u00e1 p\u0159ed\u010d\u00edtat p\u0159edem dan\u00e1 slova.<\/p>\n\n\n\n<p>\u201e<em>Obecn\u011b je hlas lid\u00ed s&nbsp;Parkinsonovou nemoc\u00ed v\u00edce monot\u00f3nn\u00ed \u2013 to odli\u0161uje jejich \u0159e\u010d od mluvy zdrav\u00e9ho \u010dlov\u011bka. Typick\u00e1 je zhor\u0161en\u00e1 melodie \u0159e\u010di, hlasitost a srozumitelnost. V&nbsp;pozd\u011bj\u0161\u00edch stadi\u00edch nemoci jsou tyto obt\u00ed\u017ee dob\u0159e sly\u0161iteln\u00e9. Na po\u010d\u00e1tku ale mohou b\u00fdt zm\u011bny jen velmi nepatrn\u00e9 \u2013 i ty v\u0161ak dok\u00e1\u017ee na\u0161e aplikace spolehliv\u011b rozpoznat,\u201c <\/em>p\u0159ibli\u017euje neurolog. U\u017e d\u0159\u00edve se jeho t\u00fdmu poda\u0159ilo popsat t\u0159i typy \u0159e\u010dov\u00fdch poruch, kter\u00e9 pacienty s&nbsp;Parkinsonovou nemoc\u00ed postihuj\u00ed. <em>\u201ePodle toho, jakou poruchou pacient trp\u00ed, jsme schopni p\u0159edpov\u011bd\u011bt, jak se bude jeho nemoc d\u00e1le vyv\u00edjet a jak zareaguje na l\u00e9\u010dbu. Nejh\u016f\u0159e odpov\u00eddaj\u00ed na terapii pacienti se zhor\u0161enou artikulac\u00ed, kte\u0159\u00ed maj\u00ed obecn\u011b pr\u016fb\u011bh nemoci t\u011b\u017e\u0161\u00ed,\u201c<\/em> popisuje doc. Du\u0161ek.<\/p>\n\n\n\n<p>Aktu\u00e1ln\u011b je mobiln\u00ed aplikace, vyvinut\u00e1 na Fakult\u011b elektrotechnick\u00e9 \u010cVUT, ve f\u00e1zi testov\u00e1n\u00ed \u2013 odborn\u00edci jsou ale z&nbsp;prvn\u00edch v\u00fdsledk\u016f nad\u0161eni. <em>\u201eAplikace je velmi spolehliv\u00e1. V\u00fdsledky jsou srovnateln\u00e9 s&nbsp;anal\u00fdzami hovor\u016f, kter\u00e9 jsme s&nbsp;pacienty nahr\u00e1vali v&nbsp;laboratorn\u00edch podm\u00ednk\u00e1ch na kvalitn\u00ed mikrofon. Mobil by se tak do budoucna mohl skute\u010dn\u011b st\u00e1t plnohodnotn\u00fdm n\u00e1strojem, kter\u00fd n\u00e1m pom\u016f\u017ee zav\u010das diagnostikovat Parkinsonovu nemoc,\u201c<\/em> \u0159\u00edk\u00e1 doc. Ing. Jan Rusz, Ph.D., z FEL \u010cVUT, v jeho\u017e t\u00fdmu aplikace vznikla. Pr\u00e1v\u011b masov\u00e1 dostupnost a snadnost pou\u017e\u00edv\u00e1n\u00ed jsou podle v\u011bdc\u016f hlavn\u00edmi v\u00fdhodami vyvinut\u00e9ho softwaru. <em>\u201eDoposud prob\u00edhaly anal\u00fdzy \u0159e\u010di tak, \u017ee pacient p\u0159i\u0161el k&nbsp;n\u00e1m na kliniku, tam jsme mu nasadili profesion\u00e1ln\u00ed mikrofon a v&nbsp;tich\u00e9 m\u00edstnosti musel p\u016fl hodiny plnit zadan\u00e9 \u00fakoly. D\u00edky mobilu se v\u0161e zjednodu\u0161ilo \u2013 te\u010f sta\u010d\u00ed, kdy\u017e si \u010dlov\u011bk st\u00e1hne aplikaci a ud\u011bl\u00ed souhlas s&nbsp;odes\u00edl\u00e1n\u00edm hovor\u016f k&nbsp;anal\u00fdze,\u201c<\/em> \u0159\u00edk\u00e1 Ing. Vojt\u011bch Illner, Ph.D., z FEL \u010cVUT, hlavn\u00ed autor studie.<\/p>\n\n\n\n<p>V\u00fdsledky p\u0159elomov\u00e9 studie prezentovali v\u011bdci p\u0159ed \u010dasem na 2. v\u00fdro\u010dn\u00ed konferenci N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum, kter\u00e1 se uskute\u010dnila v&nbsp;Praze. <em>\u201eVyvinut\u00e1 mobiln\u00ed aplikace je naprosto unik\u00e1tn\u00ed. V&nbsp;\u010cesku jsme zat\u00edm v&nbsp;pou\u017e\u00edv\u00e1n\u00ed podobn\u00fdch technologi\u00ed teprve na za\u010d\u00e1tku. Prob\u00edhaj\u00ed r\u016fzn\u00e9 v\u00fdzkumy, na na\u0161em pracovi\u0161ti se nap\u0159\u00edklad sna\u017e\u00edme vyvinout aplikaci pro pacienty s&nbsp;funk\u010dn\u00edmi neurologick\u00fdmi poruchami. Software pro \u010dasnou diagnostiku je ale v\u00fdjime\u010dn\u00fd \u2013 za jeho hlavn\u00ed v\u00fdhodu pova\u017euji u\u017eivatelskou p\u0159\u00edv\u011btivost,\u201c <\/em>\u0159\u00edk\u00e1 prof. MUDr. Milan Br\u00e1zdil, Ph.D., FRCP, v\u011bdeck\u00fd \u0159editel N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum a p\u0159ednosta I. neurologick\u00e9 kliniky FNUSA a LF MU.<\/p>\n\n\n\n<p>Aby bylo mo\u017en\u00e9 p\u0159ev\u00e9st aplikaci do praxe, je ale podle doc. Du\u0161ka pot\u0159eba dal\u0161\u00ed testov\u00e1n\u00ed. V\u011bdci by cht\u011bli vyzkou\u0161et jin\u00e9 typy mobiln\u00edch za\u0159\u00edzen\u00ed a tak\u00e9 anal\u00fdzu \u0159e\u010di v&nbsp;dal\u0161\u00edch jazyc\u00edch. <em>\u201eChyst\u00e1me se na dobu, kdy budeme m\u00edt k&nbsp;dispozici l\u00e9\u010dbu, kter\u00e1 by dok\u00e1zala zcela zastavit postup Parkinsonovy nemoci, pokud by se choroba odhalila dostate\u010dn\u011b brzy. S&nbsp;pomoc\u00ed pasivn\u00edch biomarker\u016f \u2013 nap\u0159\u00edklad na\u0161\u00ed aplikace \u2013 bychom pak mohli snadno prov\u00e1d\u011bt screening nap\u0159\u00ed\u010d populac\u00ed. Lid\u00e9 by nemuseli podstupovat slo\u017eit\u00e1 vy\u0161et\u0159en\u00ed, ale otestovali by se sami. A v&nbsp;p\u0159\u00edpad\u011b pozitivn\u00edho n\u00e1lezu by se nasadila \u00fa\u010dinn\u00e1 terapie, kter\u00e1 by rozvoj nemoci zastavila,\u201c<\/em> p\u0159ibli\u017euje vize do budoucna doc. Du\u0161ek.<\/p>\n\n\n\n<p>Parkinsonova nemoc je neurodegenerativn\u00ed onemocn\u011bn\u00ed centr\u00e1ln\u00ed nervov\u00e9 soustavy, kter\u00e9 souvis\u00ed s&nbsp;\u00fabytkem nervov\u00fdch bun\u011bk. Pacienti postupn\u011b ztr\u00e1cej\u00ed schopnost kontrolovat sv\u016fj pohyb, objevuje se t\u0159es i probl\u00e9my s&nbsp;pam\u011bt\u00ed nebo dal\u0161\u00ed kognitivn\u00ed poruchy. Podle odhad\u016f v&nbsp;\u010cesku chorobou trp\u00ed a\u017e 50&nbsp;000 lid\u00ed. V&nbsp;d\u016fsledku st\u00e1rnut\u00ed populace jejich po\u010det ka\u017edoro\u010dn\u011b nar\u016fst\u00e1. Zat\u00edm nen\u00ed mo\u017en\u00e9 nemoc vyl\u00e9\u010dit, d\u00edky c\u00edlen\u00e9 terapii jsou ale l\u00e9ka\u0159i schopni potla\u010dit p\u0159\u00edznaky a zpomalit jej\u00ed rozvoj. <em>\u201eNeurodegenerativn\u00ed onemocn\u011bn\u00ed jsou dlouhodob\u00e1. S&nbsp;t\u00edm, jak se stav pacient\u016f postupn\u011b zhor\u0161uje, kles\u00e1 nejen kvalita jejich \u017eivota, ale tak\u00e9 rodin, kter\u00e9 o nemocn\u00e9 pe\u010duj\u00ed. Pokud se n\u00e1m v\u0161ak poda\u0159\u00ed zachytit nemoc v&nbsp;ran\u00e9m stadiu, m\u016f\u017eeme prodlou\u017eit dobu, po kterou pacienti a jejich nejbli\u017e\u0161\u00ed povedou plnohodnotn\u00fd \u017eivot,\u201c<\/em> dod\u00e1v\u00e1 prof. Br\u00e1zdil.<\/p>\n\n\n\n<p><strong>O Neur-INu<\/strong><\/p>\n\n\n\n<p>N\u00e1rodn\u00ed \u00fastav pro neurologick\u00fd v\u00fdzkum (National Institute for Neurological Research \u2013 NINR, nov\u011b Neur-IN) je v\u00fdzkumn\u00e1 platforma propojuj\u00edc\u00ed 45 excelentn\u00edch neurologick\u00fdch t\u00fdm\u016f z jeden\u00e1cti p\u0159edn\u00edch v\u011bdeck\u00fdch instituc\u00ed v \u010cR. Jej\u00edm c\u00edlem je podpo\u0159it v\u00fdzkum p\u0159edev\u0161\u00edm neurodegenerativn\u00edch onemocn\u011bn\u00ed. Neurologick\u00e9 poruchy jsou nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou invalidity a druhou nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed. V Neur-INu je zapojeno p\u0159es 250 preklinick\u00fdch i klinick\u00fdch v\u00fdzkumn\u00edk\u016f, kte\u0159\u00ed se pod\u00edl\u00ed na multidisciplin\u00e1rn\u00edm v\u00fdzkumu neurodegenerace u \u0159ady neurologick\u00fdch onemocn\u011bn\u00ed. Krom\u011b dvou notoricky zn\u00e1m\u00fdch neurodegenerativn\u00edch chorob s dramaticky nar\u016fstaj\u00edc\u00ed prevalenc\u00ed \u2013 Alzheimerovy a Parkinsonovy choroby \u2013 se institut v\u011bnuje i dal\u0161\u00edm neurologick\u00fdm onemocn\u011bn\u00edm, u nich\u017e hraje neurodegenerace v\u00fdznamnou roli (nap\u0159\u00edklad neurov\u00fdvojov\u00e1 onemocn\u011bn\u00ed, epilepsie, roztrou\u0161en\u00e1 skler\u00f3za). Posl\u00e1n\u00edm N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum je vyhled\u00e1v\u00e1n\u00ed pr\u016flomov\u00fdch poznatk\u016f o mozku a nervov\u00e9m syst\u00e9mu a jejich vyu\u017eit\u00ed ke sni\u017eov\u00e1n\u00ed z\u00e1t\u011b\u017ee neurologick\u00fdch onemocn\u011bn\u00ed a ke zlep\u0161en\u00ed kvality \u017eivota posti\u017een\u00e9 populace. V\u00edce informac\u00ed na https:\/\/www.ninr.cz.<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Unik\u00e1tn\u00ed aplikace rozpozn\u00e1 onemocn\u011bn\u00ed z&nbsp;nahr\u00e1vky hovoru Praha, 7. 11. 2024 \u2013 P\u00e1r minut telefonn\u00edho hovoru \u2013 tolik sta\u010d\u00ed unik\u00e1tn\u00ed \u010desk\u00e9 aplikaci k tomu, aby rozpoznala <a class=\"mh-excerpt-more\" href=\"https:\/\/www.invarena.cz\/?p=52993\" title=\"Hal\u00f3 telefone, m\u00e1m \u201eparkinsona\u201c?\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":40551,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-52993","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52993"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/52993\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/40551"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}