{"id":53783,"date":"2024-12-17T03:18:23","date_gmt":"2024-12-17T02:18:23","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=53783"},"modified":"2024-12-17T03:18:38","modified_gmt":"2024-12-17T02:18:38","slug":"nova-aplikace-zjisti-parkinsonovu-nemoc","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=53783","title":{"rendered":"Nov\u00e1 aplikace zjist\u00ed Parkinsonovu nemoc\u00a0\u00a0"},"content":{"rendered":"\n

\u010cT 24\u00a0– Ud\u00e1losti, koment\u00e1\u0159e

\u010cesk\u00e1 aplikace rozpozn\u00e1 po\u010d\u00ednaj\u00edc\u00ed Parkinsonovu nemoc i za n\u011bkolik minut telefonn\u00edho hovoru. Speci\u00e1ln\u00ed software dok\u00e1\u017ee odhalit nepatrn\u00e9 zm\u011bny v hlase p\u0159edznamen\u00e1vaj\u00edc\u00ed i n\u00e1stup choroby. Na v\u00fdvoji pracuje t\u00fdm v\u011bdc\u016f a l\u00e9ka\u0159\u016f z N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum 1. L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy a Fakulty elektrotechnick\u00e9 \u010cesk\u00e9ho Vysok\u00e9ho u\u010den\u00ed technick\u00e9ho. A co o t\u00e9to chorob\u011b vlastn\u011b v\u00edme? Po\u010d\u00e1te\u010dn\u00edmi p\u0159\u00edznaky Parkinsonovy choroby jsou klidov\u00fd t\u0159es, zpomalenost pohybu, svalov\u00e1 ztuhlost a ztr\u00e1ta rovnov\u00e1hy, jde o neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 postihuje nervov\u00fd syst\u00e9m a vznik\u00e1 kv\u016fli postupn\u00e9mu odum\u00edr\u00e1n\u00ed nervov\u00fdch bun\u011bk v mozku, kter\u00e9 produkuj\u00ed dopamin. Jedn\u00e1 se o dosud nevyl\u00e9\u010diteln\u00e9 onemocn\u011bn\u00ed, proto\u017ee nejsou zn\u00e1my p\u0159\u00ed\u010diny vzniku, l\u00e9ka\u0159i ale dok\u00e1\u017eou c\u00edlenou l\u00e9\u010dbou potla\u010dit jej\u00ed p\u0159\u00edznaky a zpomalit jej\u00ed dal\u0161\u00ed rozvoj. A s n\u00e1mi u\u017e je Petr Du\u0161ek z Neurologick\u00e9 kliniky 1. L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy, v\u00edt\u00e1m v\u00e1s ve studiu, hezk\u00fd ve\u010der.

J\u00e1 to je\u0161t\u011b zopakuji, t\u0159es, zpomalenost pohybu, svalov\u00e1 ztuhlost, ztr\u00e1ta rovnov\u00e1hy a najednou takov\u00e9 p\u0159\u00edznaky nebo p\u0159\u00edznaky Parkinsonovy choroby dok\u00e1\u017ee poznat aplikace prost\u0159ednictv\u00edm telefonn\u00edho hovoru, jak to, jak to funguje?

Petr Du\u0161ek, neurolog, Neurologick\u00e1 klinika 1. LF UK a VFN v Praze, \u010dlen N\u00e1rodn\u00edho \u00fastavu pro neurologick\u00fd v\u00fdzkum Neur-IN
——————–
Parkinsonova nemoc vlastn\u011b postihuje regulaci sval\u016f, regulaci pohybu, zp\u016fsobuje zv\u00fd\u0161en\u00e9 svalov\u00e9 nap\u011bt\u00ed, zp\u016fsobuje poruchu iniciace pohybu, zp\u016fsobuje zpomalenost pohybu, vlastn\u011b na\u0161e schopnost \u0159e\u010di je z\u00e1visl\u00e1 na koordinaci cel\u00e9 \u0159ady sval\u016f, a\u0165 u\u017e v hrtanu, jazyku, mimick\u00fdch sval\u016f a nen\u00ed proto divu, \u017ee vlastn\u011b \u0159e\u010d je\u00a0posti\u017een\u00e1<\/strong>\u00a0u naprost\u00e9 v\u011bt\u0161iny pacient\u016f s Parkinsonovou nemoc\u00ed.

moder\u00e1torka \u010cT
——————–
Tak\u017ee jak ten patn\u00e1ctiminutov\u00fd rozhovor, b\u011bhem kter\u00e9ho to ta aplikace pozn\u00e1, vypad\u00e1?

Petr Du\u0161ek,
On to vlastn\u011b nen\u00ed patn\u00e1ctiminutov\u00fd rozhovor, ta aplikace vlastn\u011b monitoruje \u00fapln\u011b b\u011b\u017en\u00e9 hovory, v podstat\u011b sta\u010d\u00ed, kdy\u017e ten dan\u00fd \u010dlov\u011bk norm\u00e1ln\u011b telefonuje a po ka\u017ed\u00e9m tom hovoru si m\u016f\u017ee zvolit, jestli ty data vlastn\u011b poskytne k anal\u00fdze. A my zat\u00edm jsme to jenom vlastn\u011b testovali, v\u0161echny ty data ode\u0161ly na chr\u00e1n\u011bn\u00fd server do \u010cVUT, kde se to potom analyzovalo a teprve vlastn\u011b tou ex post anal\u00fdzou se zjistilo, \u017ee ide\u00e1ln\u00ed \u010das, kumulativn\u00ed \u010das je vlastn\u011b 15 minut celkov\u00fdch hovor\u016f a mohl to b\u00fdt, m\u016f\u017ee to b\u00fdt jeden dlouh\u00fd hovor a m\u016f\u017ee to b\u00fdt 20 kr\u00e1tk\u00fdch hovor\u016f.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
Kdo jsou ti, pro kter\u00e9 to vyv\u00edj\u00edte?

Petr Du\u0161ek,
No, my to vyv\u00edj\u00edme vlastn\u011b pro celou populaci, jo, v podstat\u011b v sou\u010dasn\u00e9 dob\u011b v \u010cesk\u00e9 republice je zhruba 40 000 pacient\u016f s Parkinsonovou nemoc\u00ed a ka\u017ed\u00fd rok je t\u011bch nov\u00fdch pacient\u016f zhruba 3000. Jo, tato pacienta, tato aplikace nen\u00ed vlastn\u011b pro nikoho ur\u010den\u00e1 konkr\u00e9tn\u011b, ale my do budoucna ty na\u0161e vize jako o\u010dek\u00e1v\u00e1me, \u017ee bysme to vlastn\u011b pou\u017eili pro celopopula\u010dn\u00ed screening vlastn\u011b po\u010d\u00ednaj\u00edc\u00ed Parkinsonovy nemoci.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
To znamen\u00e1, \u017ee pokud si tu aplikaci st\u00e1hnu a ta aplikace to pozn\u00e1, tak potom mi t\u0159eba doporu\u010d\u00ed – objednejte se k specialistovi.

Petr Du\u0161ek,
Ano, to je vize. Bohu\u017eel my tu aplikaci je\u0161t\u011b nem\u00e1me jako v repozit\u00e1\u0159\u00edch, nen\u00ed voln\u011b ke sta\u017een\u00ed, proto\u017ee je\u0161t\u011b prob\u00edh\u00e1 testov\u00e1n\u00ed jo. Ta aplikace zat\u00edm byla validovan\u00e1 na jednom konkr\u00e9tn\u00edm typu telefonu a tam se to osv\u011bd\u010dilo. M\u00e1 vlastn\u011b p\u0159esnost kolem 80 %, a to i v inici\u00e1ln\u00edm stadiu, kdy ti pacienti by je\u0161t\u011b nep\u0159i\u0161li k l\u00e9ka\u0159i. Ale co n\u00e1s te\u010fka \u010dek\u00e1, je vlastn\u011b roz\u0161\u00ed\u0159en\u00ed t\u00e9 aplikace a testov\u00e1n\u00ed na cel\u00e9 \u0159ady telefon\u016f, kter\u00e9 maj\u00ed jin\u00e9 mikrofony i jin\u00e9 vlastn\u011b charakteristiky a prok\u00e1z\u00e1n\u00ed, \u017ee to funguje vlastn\u011b univerz\u00e1ln\u011b.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
Plat\u00ed, \u017ee Parkinsonova choroba se objevuje u star\u0161\u00edch lid\u00ed nad 65, mlad\u00ed lid\u00e9 ji maj\u00ed v\u00fdjime\u010dn\u011b nebo t\u0159eba p\u0159ib\u00fdv\u00e1 i p\u0159\u00edpad\u016f mlad\u00fdch lid\u00ed, jak je to?

Petr Du\u0161ek,
Parkinsonova nemoc, ta jej\u00ed vlastn\u011b to riziko nebo ta jej\u00ed prevalence stoup\u00e1 s v\u011bkem, d\u00e1 se \u0159\u00edct, \u017ee kolem 60 let je to zhruba 1 % populace, ale nad 80 let u\u017e je to 5 % populace. Pod \u010dty\u0159ic\u00e1t\u00fdm rokem v\u011bku je to naopak velmi vz\u00e1cn\u00e9. J\u00e1 snad nejmlad\u0161\u00edho pacienta jsem vid\u011bl, to mu bylo 25 let. Ale celkov\u011b ta, vlastn\u011b to riziko nebo vlastn\u011b ta prevalence, to roz\u0161\u00ed\u0159en\u00ed v populaci roste, a to ve v\u0161ech v\u011bkov\u00fdch kategori\u00edch.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
Ta nemoc nejde l\u00e9\u010dit, jde jenom zpomalit, jak je tedy d\u016fle\u017eit\u00e9 odhalit ji v\u010das?

Petr Du\u0161ek,
Ono i to zpomalen\u00ed je vlastn\u011b hodn\u011b experiment\u00e1ln\u00ed a my nev\u00edme, jestli ty metody fungujou. To, co m\u00e1 vlastn\u011b nejv\u011bt\u0161\u00ed oporu v datech, je pravideln\u00e9 cvi\u010den\u00ed, jako ukazuje se, \u017ee lidi, kter\u00fd pravideln\u011b cvi\u010d\u00ed, a\u0165 u\u017e n\u011bjak\u00fd aerobn\u00ed tr\u00e9nink, jako ch\u016fzi, b\u011bh\u00e1n\u00ed nebo i rezistentn\u00ed tr\u00e9nink, znamen\u00e1 posilov\u00e1n\u00ed, tak prost\u011b maj\u00ed ni\u017e\u0161\u00ed riziko. A kdy\u017e u\u017e tu nemoc maj\u00ed, tak prob\u00edh\u00e1 pomaleji.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
V\u00ed se, pro\u010d ji maj\u00ed \u010dast\u011bji mu\u017ei?

Petr Du\u0161ek,
To se nev\u00ed. Maj\u00ed ji asi jeden a p\u016flkr\u00e1t \u010dast\u011bji ne\u017e \u017eeny, ale p\u0159\u00ed\u010dinu nezn\u00e1me.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
A jak dob\u0159e nebo \u0161patn\u011b se tedy d\u00e1 dnes s Parkinsonovou chorobou fungovat v norm\u00e1ln\u00edm \u017eivot\u011b?

Petr Du\u0161ek,
My m\u00e1me k dispozici l\u00e9ky, kter\u00e9 do ur\u010dit\u00e9 f\u00e1ze dok\u00e1\u017eou doplnit do mozku to, co tam chyb\u00ed, teda dopamin a hlavn\u011b v t\u011bch inici\u00e1ln\u00edch stadi\u00edch v\u00fdrazn\u011b zlep\u0161it kvalitu \u017eivota. Jako podle n\u011bkter\u00fdch studi\u00ed zaveden\u00ed levodopy, ze kter\u00fd si mozek vyr\u00e1b\u00ed dopamin, vedlo k prodlou\u017een\u00ed p\u0159e\u017eit\u00ed u Parkinsonovy nemoci a\u017e o sedm let, co\u017e je teda obrovsk\u00e9 \u010d\u00edslo jako v medic\u00edn\u011b, jo, tak\u017ee ty lidi prost\u011b prvn\u00ed roky s nemoc\u00ed, kdy\u017e jsou dob\u0159e l\u00e9\u010den\u00ed, tak v podstat\u011b funguj\u00ed jenom s mal\u00fdm omezen\u00edm.

moder\u00e1torka \u010cT
——————–
\u0158ekn\u011bte mi z\u00e1v\u011brem, jak\u00fd je p\u0159edpoklad, kdyby se ta aplikace mohla tedy u\u017e dostat i do t\u00e9 populace?

Petr Du\u0161ek,
J\u00e1 se ob\u00e1v\u00e1m, \u017ee jsou to je\u0161t\u011b roky. Jako p\u0159esn\u00fd \u010das v\u00e1m ne\u0159eknu. Z\u00e1le\u017e\u00ed, jak se\u017eeneme pen\u00edze a jak rychle bude prob\u00edhat to testov\u00e1n\u00ed a jak skute\u010dn\u011b to bude fungovat na r\u016fzn\u00fdch p\u0159\u00edstroj\u00edch.

Tereza \u0158ezn\u00ed\u010dkov\u00e1, moder\u00e1torka \u010cT
——————–
\u0158\u00edk\u00e1 Petr Du\u0161ek z Neurologick\u00e9 kliniky 1. L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy. D\u011bkuju v\u00e1m, \u017ee jste p\u0159i\u0161el. Hezk\u00fd ve\u010der.

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u010cT 24\u00a0– Ud\u00e1losti, koment\u00e1\u0159e \u010cesk\u00e1 aplikace rozpozn\u00e1 po\u010d\u00ednaj\u00edc\u00ed Parkinsonovu nemoc i za n\u011bkolik minut telefonn\u00edho hovoru. Speci\u00e1ln\u00ed software dok\u00e1\u017ee odhalit nepatrn\u00e9 zm\u011bny v hlase p\u0159edznamen\u00e1vaj\u00edc\u00ed […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14139,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-53783","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/53783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53783"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/53783\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14139"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=53783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=53783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}