{"id":56834,"date":"2025-04-29T11:24:44","date_gmt":"2025-04-29T09:24:44","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=56834"},"modified":"2025-04-29T11:24:54","modified_gmt":"2025-04-29T09:24:54","slug":"lekari-strevo-a-mozek-tvori-osu","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=56834","title":{"rendered":"L\u00e9ka\u0159i: St\u0159evo a mozek tvo\u0159\u00ed osu"},"content":{"rendered":"\n

Z\u00e1n\u011bty za\u017e\u00edvac\u00edho traktu ovliv\u0148uj\u00ed psychiku a naopak<\/em><\/p>\n\n\n\n

Praha, 29. dubna 2025 \u2013 Lid\u00e9<\/strong> s\u00a0chronick\u00fdmi z\u00e1n\u011bty st\u0159ev trp\u00ed \u010dasto \u00fazkostmi, depresemi a dal\u0161\u00edmi psychick\u00fdmi pot\u00ed\u017eemi. Nemoci, z\u00a0nich\u017e jedna s\u00eddl\u00ed ve st\u0159evech a druh\u00e1 v\u00a0mozku, jsou toti\u017e propojeny. Z\u00e1n\u011bt v\u00a0t\u011ble ovliv\u0148uje mozkovou \u010dinnost. A naopak psychick\u00fd stres je jedn\u00edm z\u00a0hlavn\u00edch d\u016fvod\u016f, pro\u010d doch\u00e1z\u00ed k naru\u0161en\u00ed st\u0159evn\u00ed sliznice, uvol\u0148ov\u00e1n\u00ed z\u00e1n\u011btliv\u00fdch l\u00e1tek a\u00a0k\u00a0riziku vzplanut\u00ed nebo zhor\u0161en\u00ed nemoci. <\/strong><\/p>\n\n\n\n

O ose st\u0159evo\u2013mozek diskutovali, krom\u011b dal\u0161\u00edch t\u00e9mat, gastroenterologov\u00e9 na 2. ro\u010dn\u00edku IBD kongresu, kter\u00fd se konal v\u00a0Praze.<\/strong><\/p>\n\n\n\n

\u201ePsychick\u00fdmi probl\u00e9my trp\u00ed v\u00edce ne\u017e polovina pacient\u016f s\u00a0idiopatick\u00fdmi st\u0159evn\u00edmi z\u00e1n\u011bty (IBD), tedy Crohnovou chorobou a ulcer\u00f3zn\u00ed kolitidou. Z\u00a0mnoh\u00fdch studi\u00ed u\u017e v\u00edme, \u017ee stres m\u011bn\u00ed bakteri\u00e1ln\u00ed prost\u0159ed\u00ed ve st\u0159ev\u011b, zvy\u0161uje propustnost sliznice, a z\u00e1n\u011bt pak pronik\u00e1 d\u00e1l do t\u011bla. Mozek a tr\u00e1vic\u00ed syst\u00e9m jsou \u00fazce propojeny, a proto pokud l\u00e9\u010d\u00edme st\u0159eva, nesm\u00edme zapom\u00ednat na du\u0161i. Je t\u0159eba, aby gastroenterologov\u00e9 \u00fazce spolupracovali s\u00a0psychiatry. Pokud je pacient v\u00a0psychick\u00e9 pohod\u011b, v\u00fdrazn\u011b to zlep\u0161uje jeho progn\u00f3zu, spolupracuje a da\u0159\u00ed se n\u00e1m udr\u017eet chronick\u00fd z\u00e1n\u011bt pod kontrolou,\u201c<\/em> vysv\u011btluje <\/strong>prof. MUDr. Milan Luk\u00e1\u0161, p\u0159ednosta klinick\u00e9ho centra ISCARE. <\/p>\n\n\n\n

Podle profesora Luk\u00e1\u0161e studie uk\u00e1zaly, \u017ee lid\u00e9 s depres\u00ed maj\u00ed ve st\u0159evech jin\u00e9 slo\u017een\u00ed bakteri\u00ed ne\u017e ti zdrav\u00ed \u2013 li\u0161\u00ed se nap\u0159\u00edklad mno\u017estv\u00ed bakteri\u00ed rodu Firmicutes, Actinobacteria a Bacteroidetes. \u201eTy jsou sice p\u0159irozenou sou\u010d\u00e1st\u00ed st\u0159evn\u00ed mikrobioty, ale pokud se jejich pom\u011br zm\u011bn\u00ed, naru\u0161\u00ed se st\u0159evn\u00ed rovnov\u00e1ha, a to zvy\u0161uje z\u00e1n\u011btliv\u00e9 procesy v\u00a0t\u011ble. Spr\u00e1vn\u00fd pom\u011br t\u011bchto bakteri\u00ed pom\u00e1h\u00e1 t\u011blu i psychice fungovat tak, jak m\u00e1. Kdy\u017e je pom\u011br rozhozen\u00fd, m\u016f\u017ee to negativn\u011b ovlivnit jak\u00a0fyzick\u00e9, tak\u00a0du\u0161evn\u00ed zdrav\u00ed,\u201c <\/em>\u0159\u00edk\u00e1 l\u00e9ka\u0159. <\/em><\/p>\n\n\n\n

U pacient\u016f s IBD by tak odborn\u00edci m\u011bli u\u017e v\u00a0dob\u011b stanoven\u00ed dia\u00adgn\u00f3zy prov\u00e9st screening du\u0161evn\u00edho onemocn\u011bn\u00ed. To ov\u0161em nar\u00e1\u017e\u00ed na \u010dasov\u00e9 mo\u017enosti l\u00e9ka\u0159\u016f, jak gastroenterolog\u016f, tak psychiatr\u016f, a tak\u00e9 na to, \u017ee se u n\u011bkter\u00fdch pacient\u016f du\u0161evn\u00ed pot\u00ed\u017ee tou dobou zat\u00edm neprojevuj\u00ed. A tak nejsou deprese a \u00fazkosti, kter\u00e9 pat\u0159\u00ed k nej\u010dast\u011bj\u0161\u00edm du\u0161evn\u00edm obt\u00ed\u017e\u00edm u pacient\u016f s\u00a0IBD, \u010dasto rozpozn\u00e1ny a l\u00e9\u010deny.<\/p>\n\n\n\n

\u201eZ\u00e1n\u011bt se propisuje do \u010dinnosti mozku, m\u011bn\u00ed jeho plasticitu \u2013 tento mechanismus je spole\u010dn\u00fd v\u0161em chorob\u00e1m, kde je z\u00e1n\u011bt p\u0159\u00edtomen, tedy krom\u011b IBD tak\u00e9 nap\u0159\u00edklad astmatu, migr\u00e9n\u011b, psori\u00e1ze, ateroskler\u00f3ze a dal\u0161\u00edm nemocem,\u201c<\/em> \u0159\u00edk\u00e1 doc. MUDr. Martin Anders, p\u0159ednosta Psychiatrick\u00e9 kliniky 1. LF UK a VFN v\u00a0Praze. P\u0159ipom\u00edn\u00e1, \u017ee antidepresiva tak\u00e9 pozitivn\u011b ovliv\u0148uj\u00ed z\u00e1n\u011btliv\u00e9 procesy v t\u011ble. \u201eNejen\u017ee pom\u00e1haj\u00ed zlep\u0161it psychick\u00fd stav, ale n\u011bkter\u00e1 z nich tak\u00e9 tlum\u00ed doutnaj\u00edc\u00ed imunitn\u00ed aktivitu, podporuj\u00ed ochranu mozkov\u00fdch bun\u011bk a zvy\u0161uj\u00ed jejich schopnost p\u0159izp\u016fsobovat se,\u201c<\/em> dod\u00e1v\u00e1 psychiatr.<\/p>\n\n\n\n

Typick\u00fdm projevem po\u010d\u00ednaj\u00edc\u00edch psychick\u00fdch obt\u00ed\u017e\u00ed je nespavost, podr\u00e1\u017ed\u011bnost nebo \u00fanava. \u010casn\u00fd z\u00e1chyt psychick\u00e9 nebo soci\u00e1ln\u00ed t\u00edsn\u011b u pacient\u016f s IBD umo\u017e\u0148uje brzk\u00e9 zah\u00e1jen\u00ed terapie a zlep\u0161en\u00ed fyzick\u00e9ho stavu pacienta. Ten pak l\u00e9pe spolupracuje p\u0159i l\u00e9\u010db\u011b nemoci, dodr\u017euje re\u017eimov\u00e1 opat\u0159en\u00ed, jako jsou nap\u0159\u00edklad dieta a pohyb.<\/p>\n\n\n\n

O vz\u00e1jemn\u00e9m propojen\u00ed IBD s\u00a0du\u0161evn\u00edmi chorobami \u2013 tedy dvousm\u011brn\u00e9 komunikaci v\u00a0ose st\u0159evo\u2013mozek, l\u00e9ka\u0159i v\u011bd\u00ed. Tomu, aby se poznatky uv\u00e1d\u011bly do praxe a \u017eivota v\u0161ech lid\u00ed, kte\u0159\u00ed trp\u00ed Crohnovou chorobou, ulcer\u00f3zn\u00ed kolitidou a dal\u0161\u00edmi variantami IBD, br\u00e1n\u00ed kapacity l\u00e9ka\u0159\u016f. <\/p>\n\n\n\n

V\u00a0\u010cesk\u00e9 republice p\u016fsob\u00ed p\u0159ibli\u017en\u011b 800 ambulantn\u00edch za\u0159\u00edzen\u00ed, podle doc. Anderse je v\u0161ak kritick\u00e9, \u017ee pr\u016fm\u011brn\u00fd v\u011bk psychiatr\u016f se pohybuje kolem 53 let, 25 % z\u00a0nich jsou star\u0161\u00ed 60 let. Podle dostupn\u00fdch \u00fadaj\u016f<\/a> z\u00a0roku 2023 hroz\u00ed v\u00a0n\u00e1sleduj\u00edc\u00edch 5 letech odchod 343 psychiatr\u016f do d\u016fchodu. \u010cekac\u00ed doby jsou tak dlouh\u00e9 a psychiatr \u010dasto nen\u00ed sou\u010d\u00e1st\u00ed t\u00fdm\u016f, kter\u00e9 pacienta l\u00e9\u010d\u00ed.<\/p>\n\n\n\n

\u201eV \u010cesku jsme sv\u011bdky epidemie IBD. Ka\u017edoro\u010dn\u011b p\u0159ib\u00fdv\u00e1 3\u20135 tis\u00edc nov\u00fdch p\u0159\u00edpad\u016f IBD a odhadujeme, \u017ee letos budeme l\u00e9\u010dit v\u00edce ne\u017e 70 tis\u00edc pacient\u016f. <\/em>V roce 2030 by se dokonce mohl jejich celkov\u00fd po\u010det vy\u0161plhat a\u017e na 80 tis\u00edc. <\/em>Situaci nijak neuleh\u010duje fakt<\/em>, \u017ee modern\u00ed c\u00edlenou l\u00e9\u010dbu nyn\u00ed dost\u00e1v\u00e1 pouze <\/em>15\u201317 % pacient\u016f. Jejich pod\u00edl by p\u0159itom m\u011bl b\u00fdt 30\u201340 %,<\/em>\u201c<\/em> uzav\u00edr\u00e1 prof. Luk\u00e1\u0161.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Z\u00e1n\u011bty za\u017e\u00edvac\u00edho traktu ovliv\u0148uj\u00ed psychiku a naopak Praha, 29. dubna 2025 \u2013 Lid\u00e9 s\u00a0chronick\u00fdmi z\u00e1n\u011bty st\u0159ev trp\u00ed \u010dasto \u00fazkostmi, depresemi a dal\u0161\u00edmi psychick\u00fdmi pot\u00ed\u017eemi. Nemoci, […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":18738,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-56834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/56834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=56834"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/56834\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/18738"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=56834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=56834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=56834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}