{"id":57381,"date":"2025-05-20T06:37:30","date_gmt":"2025-05-20T04:37:30","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=57381"},"modified":"2025-05-20T06:40:13","modified_gmt":"2025-05-20T04:40:13","slug":"lecba-vzacnych-nemoci-metody-crispr","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=57381","title":{"rendered":"L\u00e9\u010dba vz\u00e1cn\u00fdch nemoc\u00ed metodou CRISPR. Poda\u0159ilo se vyl\u00e9\u010dit nefunk\u010dn\u00ed j\u00e1tra kojence"},"content":{"rendered":"\n

<\/p>\n\n\n\n

\u010cT 1 <\/p>\n\n\n\n


Americk\u00fdm\u00a0l\u00e9ka\u0159\u016fm<\/strong>\u00a0se poda\u0159ilo vyl\u00e9\u010dit kojence se vz\u00e1cnou genetickou chorobou. Poprv\u00e9 k tomu vyu\u017eili na m\u00edru upravenou proceduru, kterou dok\u00e1zali opravit chyby v DNA. A to m\u016f\u017ee znamenat pr\u016flom u dal\u0161\u00edch\u00a0nemoc\u00ed<\/strong>\u00a0tohoto typu.<\/p>\n\n\n\n

P\u0159\u00edznaky jako p\u0159i novorozeneck\u00e9m z\u00e1n\u011btu. Kr\u00e1tce po porodu ale\u00a0l\u00e9ka\u0159i<\/strong>\u00a0zjistili, \u017ee komplikace nezp\u016fsobuje infekce.<\/p>\n\n\n\n

Rebecca Ahrens-Nicklasov\u00e1, odbornice na genovou terapii v D\u011btsk\u00e9 nemocnici ve Filadelfii
——————–
KJ se narodil s neuv\u011b\u0159iteln\u011b z\u00e1va\u017en\u00fdm, velmi vz\u00e1cn\u00fdm onemocn\u011bn\u00edm<\/strong> zvan\u00fdm deficit CPS1.<\/p>\n\n\n\n

redaktor \u010cT
——————–
Kritick\u00e1 chyba v DNA zp\u016fsobuje, \u017ee j\u00e1tra nedok\u00e1\u017e\u00ed filtrovat toxick\u00e9 l\u00e1tky, kter\u00e9 se tak hromad\u00ed v krvi. Polovina novoroze\u0148at s touto chybou nep\u0159e\u017eije prvn\u00ed t\u00fdden. Ostatn\u00ed maj\u00ed celo\u017eivotn\u00ed n\u00e1sledky. V tomto p\u0159\u00edpad\u011b to ale m\u016f\u017ee b\u00fdt jinak.<\/p>\n\n\n\n

Rebecca Ahrens-Nicklasov\u00e1, odbornice na genovou terapii v D\u011btsk\u00e9 nemocnici ve Filadelfii
——————–
Jsme r\u00e1di, \u017ee se s v\u00e1mi m\u016f\u017eeme pod\u011blit o tom, \u017ee dostal t\u0159i d\u00e1vky terapie bez jak\u00fdchkoliv komplikac\u00ed a \u017ee vykazuje prvn\u00ed zn\u00e1mky zlep\u0161en\u00ed.<\/p>\n\n\n\n

redaktor \u010cT
——————–
Na m\u00edru upraven\u00fd\u00a0l\u00e9k<\/strong>\u00a0dok\u00e1\u017ee chyby v DNA naj\u00edt a opravit. D\u00edky tomu tak j\u00e1tra za\u010d\u00ednaj\u00ed postupn\u011b fungovat.<\/p>\n\n\n\n

Nicole Muldoonov\u00e1, matka
——————–
Up\u0159\u00edmn\u011b. v\u0161echny pokroky, kter\u00fdch dosahuje, nebo r\u016fzn\u00e9 momenty ve v\u00fdvoji, kter\u00e9 u n\u011bj te\u010f vid\u00edme, n\u00e1m potvrzuj\u00ed, \u017ee to funguje. Jeho vyhl\u00eddky upadaly \u00fapln\u011b jinak, dokud jsme neza\u010dali mluvit o genov\u00e9 terapii a infuz\u00edch.<\/p>\n\n\n\n

redaktor \u010cT
——————–
V\u011bdci v tomto p\u0159\u00edpad\u011b vyu\u017eili metodu CRISPR pro genetickou \u00fapravu DNA. V roce 2020 z\u00edskala Nobelovu cenu. Na v\u00fdvoji se v\u00fdznamn\u011b pod\u00edlel i \u010cech Martin Jinek.<\/p>\n\n\n\n

Martin j\u00ednek, biochemik, struktur\u00e1ln\u00ed biolog
——————–
K nepozn\u00e1n\u00ed zm\u011bn\u00ed lidstvo, zm\u011bn\u00ed medic\u00ednu, zm\u011bn\u00ed biotechnologie v zem\u011bd\u011blstv\u00ed.<\/p>\n\n\n\n

moder\u00e1tor \u010cT
——————–
CRISPR zm\u011bn\u00ed m\u016fj osobn\u00ed \u017eivot tak, \u017ee…? Jak dopln\u00edte tuto v\u011btu?<\/p>\n\n\n\n

Martin j\u00ednek, biochemik, struktur\u00e1ln\u00ed biolog
——————–
Tak \u017ee bude pou\u017e\u00edv\u00e1n k l\u00e9\u010db\u011b d\u011bdi\u010dn\u00fdch\u00a0nemoc\u00ed<\/strong>, k l\u00e9\u010db\u011b rakoviny nebo n\u011bkter\u00fdch typ\u016f rakovin nejsp\u00ed\u0161e, mo\u017en\u00e1 se s n\u00edm setk\u00e1me v geneticky modifikovan\u00fdch rostlin\u00e1ch nebo jin\u00fdch organismech.<\/p>\n\n\n\n

redaktor \u010cT
——————–
\u017divoty zachra\u0148uje u\u017e te\u010f. Genetick\u00e1 l\u00e9\u010dba na m\u00edru upraven\u00fdmi\u00a0l\u00e9ky<\/strong>\u00a0je nad\u011bj\u00ed hlavn\u011b pro d\u011bti, kter\u00e9 se s genetick\u00fdmi\u00a0nemocemi<\/strong>\u00a0u\u017e narod\u00ed. <\/p>\n\n\n\n

\u010cesk\u00e1 televize<\/p>\n","protected":false},"excerpt":{"rendered":"

\u010cT 1 Americk\u00fdm\u00a0l\u00e9ka\u0159\u016fm\u00a0se poda\u0159ilo vyl\u00e9\u010dit kojence se vz\u00e1cnou genetickou chorobou. Poprv\u00e9 k tomu vyu\u017eili na m\u00edru upravenou proceduru, kterou dok\u00e1zali opravit chyby v DNA. A […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":29844,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-57381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57381","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=57381"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57381\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/29844"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=57381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=57381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=57381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}