{"id":57804,"date":"2025-05-30T07:38:18","date_gmt":"2025-05-30T05:38:18","guid":{"rendered":"https:\/\/www.invarena.cz\/?p=57804"},"modified":"2025-05-30T07:38:19","modified_gmt":"2025-05-30T05:38:19","slug":"krevni-testy-pomahaji-odhalit-proc-se-nedari-otehotnet-neprijemna-biopsie-uz-neni-nutna","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=57804","title":{"rendered":"Krevn\u00ed testy pom\u00e1haj\u00ed odhalit, pro\u010d se neda\u0159\u00ed ot\u011bhotn\u011bt. Nep\u0159\u00edjemn\u00e1 biopsie u\u017e nen\u00ed nutn\u00e1"},"content":{"rendered":"\n

Nov\u00e9 metody pacientky u\u0161et\u0159\u00ed bolestiv\u00fdch z\u00e1krok\u016f<\/em><\/p>\n\n\n\n

Praha, 29. kv\u011btna 2025 \u2013 Z jednoho odb\u011bru krve dnes l\u00e9ka\u0159i um\u00ed zjistit, kdy m\u00e1 \u017eena nejvy\u0161\u0161\u00ed \u0161anci na po\u010det\u00ed nebo co je p\u0159\u00ed\u010dinou opakovan\u00fdch potrat\u016f. Pacientky tak u\u017e nemus\u00ed podstupovat invazivn\u00ed z\u00e1kroky, jako je biopsie d\u011blo\u017en\u00ed sliznice nebo odb\u011br plodov\u00e9 vody. <\/strong><\/p>\n\n\n\n

Modern\u00ed krevn\u00ed testy \u0161et\u0159\u00ed jejich \u010das, u\u0161et\u0159\u00ed je bolestiv\u00e9ho z\u00e1kroku a z\u00e1rove\u0148 zvy\u0161uj\u00ed \u0161anci na ot\u011bhotn\u011bn\u00ed. Jednou z\u00a0metod, kter\u00e1 p\u0159in\u00e1\u0161\u00ed z\u00e1sadn\u00ed posun v l\u00e9\u010db\u011b neplodnosti, je vy\u0161et\u0159en\u00ed, kter\u00e9 pom\u00e1h\u00e1 ur\u010dit p\u0159esn\u00e9 \u201eokno\u201c d\u011blo\u017en\u00ed receptivity, tedy nejlep\u0161\u00ed dobu, kdy je sliznice p\u0159ipraven\u00e1 p\u0159ijmout embryo.<\/strong><\/p>\n\n\n\n

\u201eNejvhodn\u011bj\u0161\u00ed doba pro uhn\u00edzd\u011bn\u00ed embrya je obvykle mezi 19. a\u017e 21. dnem menstrua\u010dn\u00edho cyklu. Jen\u017ee ka\u017ed\u00e1 \u017eena je jin\u00e1, a u mnoha z nich m\u016f\u017ee b\u00fdt toto implanta\u010dn\u00ed okno posunut\u00e9,\u201c<\/em> vysv\u011btluje MUDr. Marcel \u0160telcl, vedouc\u00ed l\u00e9ka\u0159 brn\u011bnsk\u00e9 kliniky ReproGenesis. \u201eTo znamen\u00e1, \u017ee optim\u00e1ln\u00ed \u010das pro p\u0159enos embrya nast\u00e1v\u00e1 bu\u010f d\u0159\u00edve, nebo pozd\u011bji, ne\u017e p\u0159edpokl\u00e1d\u00e1me<\/em>. V\u00fdsledkem je, \u017ee se embryo s d\u011blo\u017en\u00ed sliznic\u00ed nesejde ve spr\u00e1vn\u00fd moment a pokus o oplodn\u011bn\u00ed kon\u010d\u00ed ne\u00fasp\u011b\u0161n\u011b,\u201c<\/em> dopl\u0148uje l\u00e9ka\u0159.<\/p>\n\n\n\n

P\u0159esn\u011b s t\u00edmto probl\u00e9mem pom\u00e1h\u00e1 nov\u00e1 metoda, se kterou od leto\u0161n\u00edho roku v brn\u011bnsk\u00e9 reproduk\u010dn\u00ed klinice pracuj\u00ed. D\u00edky n\u00ed dok\u00e1\u017e\u00ed specialist\u00e9 jasn\u011b ur\u010dit, kdy je d\u011bloha \u017eeny skute\u010dn\u011b p\u0159ipraven\u00e1 p\u0159ijmout embryo. Sta\u010d\u00ed jim k\u00a0tomu jedin\u00fd vzorek krve pacientky.<\/p>\n\n\n\n

\u201eTest vyhodnocuje sign\u00e1ly z d\u011blo\u017en\u00ed sliznice, konkr\u00e9tn\u011b mRNA, kter\u00e9 se dost\u00e1vaj\u00ed do krevn\u00edho ob\u011bhu. Z krve tak dok\u00e1\u017eeme zjistit, jestli se embryo uhn\u00edzd\u00ed, nebo jestli pot\u0159ebujeme na\u010dasov\u00e1n\u00ed p\u0159enosu upravit<\/em>. Oproti d\u0159\u00edv\u011bj\u0161\u00edm metod\u00e1m nen\u00ed nutn\u00e1 \u017e\u00e1dn\u00e1 invazivn\u00ed biopsie d\u011blo\u017en\u00ed sliznice, co\u017e je pro pacientku podstatn\u011b komfortn\u011bj\u0161\u00ed,\u201c<\/em> \u0159\u00edk\u00e1 MUDr. \u0160telcl. Tento test pom\u016f\u017ee p\u0159edev\u0161\u00edm t\u011bm \u017een\u00e1m, kter\u00e9 za sebou maj\u00ed n\u011bkolik ne\u00fasp\u011b\u0161n\u00fdch pokus\u016f o ot\u011bhotn\u011bn\u00ed, p\u0159esto\u017ee transferovan\u00e1 embrya byla v\u00a0po\u0159\u00e1dku. Kdy\u017e l\u00e9ka\u0159i slad\u00ed term\u00edn p\u0159enosu s re\u00e1lnou p\u0159ipravenost\u00ed d\u011blo\u017en\u00ed sliznice, \u0161ance na ot\u011bhotn\u011bn\u00ed v\u00fdrazn\u011b stoup\u00e1.<\/p>\n\n\n\n

Na odb\u011bru krve je zalo\u017eena i dal\u0161\u00ed modern\u00ed metoda, kter\u00e1 pom\u00e1h\u00e1 objasnit p\u0159\u00ed\u010diny samovoln\u00e9ho potratu. Nej\u010dast\u011bj\u0161\u00edm d\u016fvodem, pro\u010d se t\u011bhotenstv\u00ed v\u00a0ran\u00e9m stadiu zastav\u00ed, b\u00fdv\u00e1 genetick\u00e1 odchylka. Jen mal\u00e9 procento potrat\u016f m\u00e1 jinou p\u0159\u00ed\u010dinu, nap\u0159\u00edklad poruchu imunity, \u0161t\u00edtn\u00e9 \u017el\u00e1zy nebo sr\u00e1\u017elivosti krve. <\/p>\n\n\n\n

Doned\u00e1vna ale l\u00e9ka\u0159i mnohdy nedok\u00e1zali p\u0159esn\u011b ur\u010dit, co se v\u00a0t\u011ble \u017eeny stalo. \u201eSice m\u00e1me k dispozici genetick\u00e9 vy\u0161et\u0159en\u00ed z potratov\u00e9ho materi\u00e1lu, to v\u0161ak bohu\u017eel ned\u00e1v\u00e1 informaci o\u00a0v\u0161ech chromozomech, ale zhruba jen o t\u0159etin\u011b z\u00a0nich. Dal\u0161\u00edm probl\u00e9mem je, \u017ee materi\u00e1l b\u00fdv\u00e1 \u010dasto kontaminov\u00e1n DNA matky,\u201c<\/em> popisuje MUDr. \u0160telcl. V\u00a0tom je pr\u00e1v\u011b nov\u00e1 metoda p\u0159elomov\u00e1. Dok\u00e1\u017ee rozkl\u00ed\u010dovat celou genetickou v\u00fdbavu embrya pouze z krve \u017eeny, bez nutnosti dal\u0161\u00edch invazivn\u00edch z\u00e1sah\u016f do t\u011bla. U pacientek, kter\u00e9 o miminko p\u0159i\u0161ly opakovan\u011b, m\u016f\u017ee test p\u0159in\u00e9st kl\u00ed\u010dov\u00e9 odpov\u011bdi a l\u00e9ka\u0159\u016fm pomoci zvolit nejvhodn\u011bj\u0161\u00ed l\u00e9\u010dbu neplodnosti. \u201ePo potratu se do krevn\u00edho ob\u011bhu pacientky uvol\u0148uj\u00ed fragmenty DNA embrya, a pr\u00e1v\u011b z t\u011bch lze zp\u011btn\u011b ur\u010dit, jestli byla p\u0159\u00ed\u010dinou genetick\u00e1 vada, nebo \u0161lo o jin\u00fd probl\u00e9m,\u201c<\/em> vysv\u011btluje l\u00e9ka\u0159.<\/p>\n\n\n\n

Ob\u011b metody p\u0159in\u00e1\u0161ej\u00ed \u017een\u00e1m komfortn\u011bj\u0161\u00ed a p\u0159esn\u011bj\u0161\u00ed cestu k potomkovi. L\u00e9ka\u0159i d\u00edky nim mohou l\u00e9pe pochopit, pro\u010d se p\u0159edchoz\u00ed pokusy o ot\u011bhotn\u011bn\u00ed nezda\u0159ily, a napl\u00e1novat dal\u0161\u00ed kroky s v\u011bt\u0161\u00ed \u0161anci na \u00fasp\u011bch, bez nutnosti nep\u0159\u00edjemn\u00fdch a invazivn\u00edch z\u00e1krok\u016f.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nov\u00e9 metody pacientky u\u0161et\u0159\u00ed bolestiv\u00fdch z\u00e1krok\u016f Praha, 29. kv\u011btna 2025 \u2013 Z jednoho odb\u011bru krve dnes l\u00e9ka\u0159i um\u00ed zjistit, kdy m\u00e1 \u017eena nejvy\u0161\u0161\u00ed \u0161anci na […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":50139,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-57804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=57804"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57804\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/50139"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=57804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=57804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=57804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}