\u010cT 24 <\/p>\n\n\n\n
\u0160v\u00fdcar\u0161t\u00ed v\u00fdrobci\u00a0l\u00e9k\u016f<\/strong>\u00a0v\u011b\u0159\u00ed, \u017ee \u00fasp\u011b\u0161n\u011b vyv\u00edjej\u00ed antibiotikum proti z\u00e1ke\u0159n\u00e9mu kmenu bakteri\u00ed. Dosavadn\u00ed l\u00e9\u010diva na tento kmen nezab\u00edrala.\u00a0L\u00e9k<\/strong>\u00a0by mohl pomoci pacient\u016fm a tak\u00e9 urychlit dal\u0161\u00ed v\u00fdvoj. Podle OSN je pokroku nal\u00e9hav\u011b zapot\u0159eb\u00ed. Odoln\u00fdch bakteri\u00ed toti\u017e p\u0159ib\u00fdv\u00e1 tak rychle, \u017ee by se v polovin\u011b stolet\u00ed mohly st\u00e1t nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed.<\/p>\n\n\n\n Antibiotikum v t\u00e9to misce je nejv\u011bt\u0161\u00ed nad\u011bj\u00ed lidstva v boji s bakteri\u00ed Acinetobacter baumannii. Ta zasahuje nejzraniteln\u011bj\u0161\u00ed pacienty v nemocnic\u00edch s oslabenou imunitou a vyvol\u00e1v\u00e1 z\u00e1pal plic a sepsi. Pokud tento patogen zp\u016fsob\u00ed infekci, 40 a\u017e 60 % pacient\u016f ji nep\u0159e\u017eije. Bakterie je toti\u017e odoln\u00e1 v\u016f\u010di dosavadn\u00edm antibiotik\u016fm. \u0160v\u00fdcar\u0161t\u00ed v\u011bdci ale v\u011b\u0159\u00ed, \u017ee se to brzy zm\u011bn\u00ed. D\u00edky jejich\u00a0l\u00e9ku<\/strong>.<\/p>\n\n\n\n Michael Lobritz, vedouc\u00ed odd\u011blen\u00ed infek\u010dn\u00edch nemoc\u00ed<\/strong>, firma Roche redaktorka Michael Lobritz, vedouc\u00ed odd\u011blen\u00ed infek\u010dn\u00edch nemoc\u00ed<\/strong>, firma Roche Dominika V\u0159e\u0161\u0165\u00e1lov\u00e1, redaktorka Andy Edwards, vyu\u010duj\u00edc\u00ed mikrobiologie, Imperial College London Dominika V\u0159e\u0161\u0165\u00e1lov\u00e1, redaktorka \u010cesk\u00e1 televize<\/p>\n","protected":false},"excerpt":{"rendered":" \u010cT 24 \u0160v\u00fdcar\u0161t\u00ed v\u00fdrobci\u00a0l\u00e9k\u016f\u00a0v\u011b\u0159\u00ed, \u017ee \u00fasp\u011b\u0161n\u011b vyv\u00edjej\u00ed antibiotikum proti z\u00e1ke\u0159n\u00e9mu kmenu bakteri\u00ed. Dosavadn\u00ed l\u00e9\u010diva na tento kmen nezab\u00edrala.\u00a0L\u00e9k\u00a0by mohl pomoci pacient\u016fm a tak\u00e9 urychlit dal\u0161\u00ed […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":27888,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-57880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=57880"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/57880\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/27888"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=57880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=57880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=57880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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S t\u00edmto nov\u00fdm antibiotikem naru\u0161ujeme fungov\u00e1n\u00ed vn\u011bj\u0161\u00ed membr\u00e1ny (bakterie).<\/p>\n\n\n\n
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P\u0159\u00edpravek zp\u016fsobuje, \u017ee se uvnit\u0159 bakterie hromad\u00ed toxiny, kter\u00e9 ji nakonec usmrt\u00ed. Antibiotikum je ve t\u0159et\u00ed f\u00e1zi klinick\u00fdch test\u016f a u\u017e pomohlo prvn\u00edm kriticky nemocn\u00fdm pacient\u016fm, kte\u0159\u00ed si ho dobrovoln\u011b nechali podat. Firma vyv\u00edjej\u00edc\u00ed tento\u00a0l\u00e9k<\/strong>\u00a0p\u0159ipom\u00edn\u00e1, \u017ee z\u00e1kladn\u00ed slo\u017eky dne\u0161n\u00edch antibiotik lidstvo objevilo u\u017e v 1. polovin\u011b 20. stolet\u00ed. Domn\u00edv\u00e1 se, \u017ee je t\u0159eba hledat nov\u00e9.<\/p>\n\n\n\n
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Abychom p\u0159ekonali vzniklou rezistenci, chceme naj\u00edt zbrusu nov\u00e9 chemick\u00e9 struktury. Tak jako lid\u00e9 tehdy ve zlat\u00e9m v\u011bku (v\u00fdvoje antibiotik). Snad n\u00e1m to pokryje pot\u0159ebu antibiotik v p\u0159\u00ed\u0161t\u00edch sto letech.<\/p>\n\n\n\n
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V\u00fdzkum je nutn\u00fd i proto, \u017ee dosavadn\u00ed antibiotika svou \u00fa\u010dinnost ztr\u00e1c\u00ed. Lid\u00e9 je nadu\u017e\u00edvaj\u00ed nap\u0159\u00edklad v zem\u011bd\u011blstv\u00ed nebo p\u0159i nevhodn\u00e9 l\u00e9\u010db\u011b. A bakterie se rychle p\u0159izp\u016fsobuj\u00ed. Podle v\u011bdc\u016f na\u0161t\u011bst\u00ed nabral tempo i v\u011bdeck\u00fd v\u00fdvoj, do kter\u00e9ho po letech investuj\u00ed velk\u00e9 farmaceutick\u00e9 firmy.<\/p>\n\n\n\n
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St\u00e1le m\u00e1me p\u0159ed sebou velmi dlouhou cestu. D\u011bl\u00e1m si ale docela velk\u00e9 nad\u011bje, \u017ee m\u00e1me za sebou to nejhor\u0161\u00ed. A douf\u00e1m, \u017ee sledujeme za\u010d\u00e1tek konce tohoto probl\u00e9mu.<\/p>\n\n\n\n
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\u0160v\u00fdcar\u0161t\u00ed v\u00fdrobci doufaj\u00ed, \u017ee by stejn\u00fd princip mohli pou\u017e\u00edt i ve v\u00fdvoji\u00a0l\u00e9k\u016f<\/strong>\u00a0proti jin\u00fdm rezistentn\u00edm bakteri\u00edm. Shoduj\u00ed se ale, \u017ee je t\u0159eba dal\u0161\u00ed v\u00fdzkum, aby lidstvo z\u00edsk\u00e1valo odolnost v\u016f\u010di bakteri\u00edm rychleji, ne\u017e ji ztr\u00e1c\u00ed, <\/p>\n\n\n\n