\u010cRo Plus<\/p>\n\n\n\n
L\u00e9\u010dba se posouv\u00e1 m\u00edlov\u00fdmi kroky kup\u0159edu, a to i d\u00edky jedn\u00e9 mlad\u00e9 v\u011bdkyni z Brna. Se sv\u00fdm t\u00fdmem vytvo\u0159ila sadu n\u00e1stroj\u016f, d\u00edky kter\u00fdm je st\u0159\u00edh\u00e1n\u00ed a v\u00fdm\u011bna gen\u016f p\u0159esn\u011bj\u0161\u00ed. Pr\u00e1v\u011b za tento v\u00fdzkum Hana Pol\u00e1\u0161ek Sedl\u00e1\u010dkov\u00e1 z Biofyzik\u00e1ln\u00edho \u00fastavu Akademie v\u011bd z\u00edskala presti\u017en\u00ed pr\u00e9mii Oto Wichterleho pro mlad\u00e9 v\u011bdce a jak sama p\u0159izn\u00e1v\u00e1, je to pro ni stejn\u00e1 pocta, jako kdy\u017e coby studentka byla odm\u011bn\u011bna tzv. Nobelovou cenou pro mlad\u00e9.<\/p>\n\n\n\n
Hana Pol\u00e1\u0161ek Sedl\u00e1\u010dkov\u00e1,<\/strong> To jsou ob\u011b dv\u011b kr\u00e1sn\u00e1 ocen\u011bn\u00ed za moji pr\u00e1ci a obou dvou si moc v\u00e1\u017e\u00edm, ta Nobelova cena pro mlad\u00e9 to bylo takov\u00fd zvl\u00e1\u0161tn\u00ed, proto\u017ee to je sv\u011btov\u00e1 cena, kter\u00e1 oce\u0148uje bakal\u00e1\u0159sk\u00e9 pr\u00e1ce, ale ocen\u011bn\u00ed od akademie si velmi, velmi v\u00e1\u017e\u00edm. <\/p>\n\n\n\n redaktorka<\/strong> Vy se v\u011bnujete p\u0159esn\u00e9mu kop\u00edrov\u00e1n\u00ed DNA, tak zkuste n\u00e1m laik\u016fm vysv\u011btlit, o co vlastn\u011b jde, co si pod t\u00edm m\u00e1me p\u0159edstavit? <\/p>\n\n\n\n mluv\u010d\u00ed 3,<\/strong> Nejlep\u0161\u00ed je to vysv\u011btlit na v\u00fdvoji lidsk\u00e9ho t\u011bla. Vlastn\u011b na za\u010d\u00e1tku je jedna bu\u0148ka, to je vaj\u00ed\u010dko a vlastn\u011b spermie, kter\u00e9 splynou dohromady a tahle ta jedin\u00e1 bu\u0148ka se mus\u00ed n\u011bkolikr\u00e1t rozd\u011blit na dv\u011b a d\u011bl\u00ed se tak dlouho, a\u017e vznikne cel\u00e9 lidsk\u00e9 t\u011blo, kter\u00e9 m\u00e1 10 na t\u0159in\u00e1ctou t\u011bch bun\u011bk, co\u017e je opravdu moc a p\u0159i ka\u017ed\u00e9m tady tom rozd\u011blen\u00ed se mus\u00ed zkop\u00edrovat ve\u0161ker\u00fd genetick\u00fd materi\u00e1l, a to pr\u00e1v\u011b zaji\u0161\u0165uje replikace DNA a my studujeme, jak ten proces prob\u00edh\u00e1, nebo kdy\u017e vzniknou n\u011bjak\u00e9 chyby, tak, jak se opravuj\u00ed, proto\u017ee mohou v\u00e9st k z\u00e1va\u017en\u00fdm onemocn\u011bn\u00edm, v\u010detn\u011b t\u0159eba rakoviny. <\/p>\n\n\n\n redaktorka <\/strong>V genov\u00e9m in\u017een\u00fdrstv\u00ed se vlastn\u011b pom\u011brn\u011b kr\u00e1tkou dobu z hlediska v\u011bdy pou\u017e\u00edv\u00e1 metoda CRISPR, vlastn\u011b to st\u0159\u00edh\u00e1n\u00ed toho \u0159et\u011bzce DNA, tak\u017ee o to d\u016fle\u017eit\u011bj\u0161\u00ed je ta p\u0159esn\u00e1 replikace, ta p\u0159esn\u00e1 kopie, ano. <\/p>\n\n\n\n mluv\u010d\u00ed 3,<\/strong> Proto\u017ee on vlastn\u011b, jak ten CRISPR \u0161t\u00edpe, tak vytv\u00e1\u0159\u00ed zlomy a ty zlomy se mus\u00ed spr\u00e1vn\u011b opravit. Kdyby se neopravily a te\u010f tam p\u0159i\u0161la ta replika\u010dn\u00ed vidli\u010dka, tak by to vedlo ke katastrof\u011b, proto\u017ee by najednou nem\u011bla odkud kop\u00edrovat. <\/p>\n\n\n\n redaktorka<\/strong> Jak\u00fd je ten v\u00e1\u0161 p\u0159\u00edsp\u011bvek tady k tomuto probl\u00e9mu? <\/p>\n\n\n\n mluv\u010d\u00ed 3,<\/strong> Cel\u00fd ten apar\u00e1t, jak jsem \u0159\u00edkala, replika\u010dn\u00ed vidli\u010dka, tak je poh\u00e1n\u011bn\u00fd takov\u00fdm zvl\u00e1\u0161tn\u00edm proteinov\u00fdm komplexem. Byly objeveny v roce 1985, ale od toho roku 1985 jsme nebyli schopni ty komplexy vizualizovat v bu\u0148k\u00e1ch, nebyli k tomu n\u00e1stroje a pr\u00e1v\u011b s metodou CRISPR n\u00e1m se pak poda\u0159ilo v laborato\u0159i vyvinout p\u0159\u00edstup, abychom ty proteiny mohli vizualizovat, a to byla jedna z t\u011bch na\u0161ich prac\u00ed, kter\u00e1 objasnila tady tu z\u00e1hadu. Tak\u017ee na\u0161e te\u010fka n\u00e1stroje jsou r\u016fzn\u011b sd\u00edlen\u00fd po cel\u00fdch laborato\u0159\u00edch sv\u011bta v Singapuru, v Hongkongu, v Americe. Skoro ka\u017ed\u00fd t\u00fdden pos\u00edl\u00e1me na\u0161e n\u00e1stroje do r\u016fzn\u00fdch laborato\u0159\u00ed.<\/p>\n\n\n\n redaktorka<\/strong> Je to hrozn\u011b zaj\u00edmav\u00e9, \u017ee \u0159\u00edk\u00e1te, my jsme v roce 85 je\u0161t\u011b nem\u011bli tady tuhletu informaci, ale vy jste ani nebyla na sv\u011bt\u011b.<\/p>\n\n\n\n mluv\u010d\u00ed 3,<\/strong> Ale jsem s tou oblast\u00ed, tedy replikace, spjat\u00e1 u\u017e od roku 2016 a zn\u00e1m vlastn\u011b i tu komunitu t\u011bch v\u011bdc\u016f a trouf\u00e1m si \u0159\u00edct, \u017ee jsem jej\u00ed sou\u010d\u00e1st\u00ed. <\/p>\n\n\n\n redaktorka<\/strong> Tak\u017ee vlastn\u011b ostatn\u00edm v\u011bdc\u016fm ukazujete, jak to maj\u00ed d\u011blat, jste pro n\u011b vymysleli prost\u011b n\u011bjak\u00fd ten z\u00e1kladn\u00ed postup, aby mohli b\u00e1dat d\u00e1l. <\/p>\n\n\n\n mluv\u010d\u00ed 3,<\/strong> Ano, ano, to je takov\u00fd c\u00edl moj\u00ed laborato\u0159e, ne ve fyzik\u00e1ln\u00edm \u00fastavu, my se zab\u00fdv\u00e1me nejenom samotn\u00fdm mechanismem t\u00e9 replikace, kde se sna\u017e\u00edme opravdu pochopit, jak to funguje, ale vyv\u00edj\u00edme pr\u00e1v\u011b i tady ty n\u00e1stroje a jsme v tom celkem \u00fasp\u011b\u0161n\u00ed, ned\u00e1vno jsme vymysleli dal\u0161\u00ed n\u00e1stroj pomoc\u00ed um\u011bl\u00e9 inteligence zase na anal\u00fdzu rychlosti t\u011bch replika\u010dn\u00edch vidli\u010dek a v moment\u011b, jak jsme to prezentovali, tak znovu je ten z\u00e1jem obrovsk\u00fd, dokonce i od farmaceutick\u00fdch firem, kter\u00e9 vyv\u00edj\u00ed pr\u00e1v\u011b l\u00e9\u010diva proti rakovin\u011b, tak to je pro n\u00e1s v\u017edycky hodn\u011b d\u016fle\u017eit\u00e9, \u017ee vid\u00edme, \u017ee ta na\u0161e pr\u00e1ce je ocen\u011bn\u00e1 ve sv\u011bt\u011b a \u017ee m\u00e1 i aplika\u010dn\u00ed potenci\u00e1l.<\/p>\n\n\n\n redaktorka<\/strong> \u0158\u00edk\u00e1 Hana Pol\u00e1\u0161ek Sedl\u00e1\u010dkov\u00e1, \u010derstv\u00e1 dr\u017eitelka pr\u00e9mie Oto Wichterleho <\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u010cRo Plus L\u00e9\u010dba se posouv\u00e1 m\u00edlov\u00fdmi kroky kup\u0159edu, a to i d\u00edky jedn\u00e9 mlad\u00e9 v\u011bdkyni z Brna. Se sv\u00fdm t\u00fdmem vytvo\u0159ila sadu n\u00e1stroj\u016f, d\u00edky kter\u00fdm […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":39888,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-58464","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rozhovory"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/58464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=58464"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/58464\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/39888"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=58464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=58464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=58464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}