Radio\u017eurn\u00e1l<\/p>\n\n\n\n
Nov\u00e9 v\u011bdeck\u00e9 objevy i rozs\u00e1hl\u00e9 investice do p\u0159\u00edstrojov\u00e9ho vybaven\u00ed, tohle v\u0161echno umo\u017enila spolupr\u00e1ce mezi v\u011bdeck\u00fdmi institucemi pod hlavi\u010dkou N\u00e1rodn\u00edho institutu pro v\u00fdzkum metabolick\u00fdch a kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed kardia, jak v\u011bdci vyu\u017eili miliardu korun z evropsk\u00fdch pen\u011bz. No, zd\u00e1 se, \u017ee velmi dob\u0159e. <\/p>\n\n\n\n
Petr Kr\u00e1l,moder\u00e1tor<\/p>\n\n\n\n
Zalo\u017een\u00ed registru pacient\u016f s cukrovkou prvn\u00edho typu, anebo tak\u00e9 v\u00fdvoj l\u00e9\u010div, kter\u00e1 v budoucnu m\u016f\u017eou zlep\u0161it \u017eivot lid\u00ed s nemocemi srdce a c\u00e9v, i tohle se povedlo d\u00edky jedn\u00e9 miliard\u011b korun z evropsk\u00fdch pen\u011bz ur\u010den\u00e9 pro N\u00e1rodn\u00ed institut pro v\u00fdzkum metabolick\u00fdch a kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed, a v\u011bdci si d\u00edky tomu mohli tak\u00e9 po\u0159\u00eddit nov\u00e9 vybaven\u00ed pro \u0161pi\u010dkov\u00fd v\u00fdzkum.<\/p>\n\n\n\n
Pro IKEM to byla nap\u0159\u00edklad experiment\u00e1ln\u00ed magnetick\u00e1 rezonance, kter\u00e1 skute\u010dn\u011b umo\u017e\u0148uje perfektn\u00ed metabolick\u00e9 v\u00fdzkumy vlastn\u011b v tom preklinick\u00e9m v\u00fdzkumu.<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
Popisuje \u0159editel Kardia a p\u0159ednosta Centra diabetologie pra\u017esk\u00e9ho IKEMu Martin Haluz\u00edk.<\/p>\n\n\n\n
mluv\u010d\u00ed 2,<\/p>\n\n\n\n
Proto\u017ee my nap\u0159\u00edklad ve spolupr\u00e1ci s kolegy z \u00dastavu organick\u00e9 chemie a biochemie se sna\u017e\u00edme vyvinout i nov\u00e9 l\u00e9ky na obezitu proti st\u00e1rnut\u00ed, tzv. antisenescen\u010dn\u00ed l\u00e9ky. Tahle investice n\u00e1m skute\u010dn\u011b umo\u017e\u0148uje v tom experimentu zkoumat n\u011bco, co jsme p\u0159edt\u00edm nemohli.<\/p>\n\n\n\n
00:07:57<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
Z\u00e1sadn\u00ed finan\u010dn\u00ed injekci p\u0159inesla kardia tak\u00e9 Fyziologick\u00e9mu \u00fastavu Akademie v\u011bd, zalo\u017eili tu novou laborato\u0159 zam\u011b\u0159enou na kardiovaskul\u00e1rn\u00ed v\u00fdzkum a po\u0159\u00eddili i unik\u00e1tn\u00ed sestavu pro metabolick\u00e9 a lipidomick\u00e9 anal\u00fdzy biologick\u00fdch vzork\u016f. Celkem se v Cardi spojili \u0161pi\u010dkov\u00ed v\u011bdci z p\u011bti v\u011bdeck\u00fdch instituc\u00ed.<\/p>\n\n\n\n
00:08:16<\/p>\n\n\n\n
mluv\u010d\u00ed 2,<\/p>\n\n\n\n
Ten projekt m\u011bl velmi v\u00fdznamnou experiment\u00e1ln\u00ed \u010d\u00e1st, preklinick\u00fd v\u00fdzkum nov\u00fdch l\u00e9k\u016f, nov\u00fdch l\u00e9\u010debn\u00fdch p\u0159\u00edstup\u016f, ale tak\u00e9 v\u00fdznamnou klinickou \u010d\u00e1st, v r\u00e1mci kter\u00e9 jsme prov\u00e1d\u011bli klinick\u00e9 studie, v\u00fdzkumy nap\u0159\u00edklad u pacient\u016f se srde\u010dn\u00edm selh\u00e1n\u00edm.<\/p>\n\n\n\n
00:08:29<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
V\u011bdci p\u0159i\u0161li i na d\u016fle\u017eit\u00e9 objevy v laborato\u0159i transla\u010dn\u00ed a experiment\u00e1ln\u00ed diabetologie a obezitologie. V pra\u017esk\u00e9m IKEMu. Nap\u0159\u00edklad na\u0161li l\u00e1tky, kter\u00e9 um\u00ed odstranit senescen\u010dn\u00ed, neboli st\u00e1rnouc\u00ed bu\u0148ky z t\u011bla.<\/p>\n\n\n\n
00:08:41<\/p>\n\n\n\n
mluv\u010d\u00ed 2,<\/p>\n\n\n\n
Kdy\u017e m\u00e1 \u010dlov\u011bk obezitu, nebo kdy\u017e m\u00e1 cukrovku nebo oboj\u00ed, tak m\u00e1 v\u00edce t\u011bch senescen\u010dn\u00edch bun\u011bk a obecn\u011b mu ty bu\u0148ky vlastn\u011b st\u00e1rnou rychleji, pokud je t\u011bch bun\u011bk p\u0159\u00edli\u0161 mnoho, tak oni se spolupod\u00edlej\u00ed na tom, \u017ee se vlastn\u011b ty nemoci d\u00e1le zhor\u0161uj\u00ed. A pokud dok\u00e1\u017eeme pomoc\u00ed n\u011bjak\u00e9 l\u00e1tky senescen\u010dn\u00ed bu\u0148ky odstranit nebo aspo\u0148 z velk\u00e9 \u010d\u00e1sti odstranit, tak vlastn\u011b m\u016f\u017eeme pozitivn\u011b ovlivnit nap\u0159\u00edklad pr\u00e1v\u011b tu cukrovku nebo ty kardiovaskul\u00e1rn\u00ed komplikace.<\/p>\n\n\n\n
00:09:05<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
Vysv\u011btluje diabetolog Martin Haluz\u00edk. V\u00fdzkumem t\u011bchto l\u00e1tek se zab\u00fdvali v\u011bdci pod veden\u00edm Soni \u0160temberkov\u00e9, Hub\u00e1\u010dkov\u00e9.<\/p>\n\n\n\n
00:09:11<\/p>\n\n\n\n
mluv\u010d\u00ed 3,<\/p>\n\n\n\n
My jsme za\u010d\u00ednali se spoustou vlastn\u011b nov\u00fdch l\u00e1tek, kter\u00e9 jsme testovali, z toho jsme si vytipovali n\u011bkolik tedy kandid\u00e1tn\u00edch, kde prob\u011bhlo preklinick\u00e9 testov\u00e1n\u00ed velmi slibn\u00e9 a do\u0161lo k patentov\u00e1n\u00ed t\u011bchto konkr\u00e9tn\u00edch l\u00e1tek, r\u00e1di bychom tedy s t\u011bmi nejslibn\u011bj\u0161\u00edmi l\u00e1tkami pokra\u010dovali do klinick\u00e9ho testov\u00e1n\u00ed.<\/p>\n\n\n\n
00:09:26<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
B\u00e1dalo se tak\u00e9 na klinice pediatrie a d\u011bdi\u010dn\u00fdch poruch metabolismu prvn\u00ed l\u00e9ka\u0159sk\u00e9 fakulty Univerzity Karlovy a V\u0161eobecn\u00e9 fakultn\u00ed nemocnice v Praze, tady v\u011bdci mimo jin\u00e9 popsali zcela nov\u00fd mechanismus Fabryho choroby. Podle Stanislava Kmocha bylo velmi v\u00fdhodn\u00e9, \u017ee se v\u011bdeck\u00e9 t\u00fdmy propojovaly i nap\u0159\u00ed\u010d v\u00fdzkumn\u00fdmi institucemi.<\/p>\n\n\n\n
00:09:45<\/p>\n\n\n\n
mluv\u010d\u00ed 4,<\/p>\n\n\n\n
Tento projekt byl typick\u00fdm projektem, kdy st\u00e1t vyvol\u00e1 popt\u00e1vku po n\u011bjak\u00e9m typu v\u00fdzkumu. Kontaktuje to nejpovolan\u011bj\u0161\u00ed pracovi\u0161t\u011b, kde jsou soust\u0159ed\u011bni ty nejt\u011b\u017e\u0161\u00ed pacienti s kardiovaskul\u00e1rn\u00edmi nemocemi. A umo\u017enil skute\u010dn\u011b vytvo\u0159it takov\u00fd multidisciplin\u00e1rn\u00ed t\u00fdm, kter\u00fd pracuje dohromady.<\/p>\n\n\n\n
00:10:05<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
Po necel\u00fdch \u010dty\u0159ech letech je financov\u00e1n\u00ed kardie u konce. V\u011bdci ale cht\u011bj\u00ed ve v\u00fdzkumech pokra\u010dovat, \u0159\u00edk\u00e1 prod\u011bkanka Masarykovy univerzity Kate\u0159ina Ka\u0148kov\u00e1.<\/p>\n\n\n\n
00:10:14<\/p>\n\n\n\n
mluv\u010d\u00ed 5,<\/p>\n\n\n\n
Te\u010f je to do jist\u00e9 m\u00edry na t\u011bch jednotliv\u00fdch t\u00fdmech nebo na t\u011bch spolupr\u00e1c\u00edch, kter\u00e9 se nastavily, aby si hledaly to financov\u00e1n\u00ed pro ka\u017ed\u00fd z t\u011bch jednotliv\u00fdch projekt\u016f, co\u017e je pr\u00e1v\u011b \u0161koda, proto\u017ee kardia byla unik\u00e1tn\u00ed t\u00edm, \u017ee umo\u017enila v jednu chv\u00edli t\u011bm lidem spolupracovat bez nutnosti se vymezovat v\u016f\u010di sob\u011b vlastn\u011b v t\u011bch grantov\u00fdch sout\u011b\u017e\u00edch, proto\u017ee byli podpo\u0159eni jako celek, pokud by byla n\u011bjak\u00e1 mo\u017enost, jak by to mohlo pokra\u010dovat, bylo by to excelentn\u00ed, ale mysl\u00edm si, \u017ee ten \u00fa\u010del vlastn\u011b nastartov\u00e1n\u00ed t\u00e9 spolupr\u00e1ce klinicko teoretick\u00e9 to splnilo.<\/p>\n\n\n\n
00:10:44<\/p>\n\n\n\n
Andrea Skalick\u00e1,moder\u00e1torka<\/p>\n\n\n\n
D\u00edky kardii tak\u00e9 vznikl celorepublikov\u00fd registr pacient\u016f s diabetem prvn\u00edho typu. <\/p>\n\n\n\n
Radio\u017eurn\u00e1l<\/p>\n\n\n\n
\u010cRo Radio\u017eurn\u00e1l<\/p>\n","protected":false},"excerpt":{"rendered":"
Radio\u017eurn\u00e1l Nov\u00e9 v\u011bdeck\u00e9 objevy i rozs\u00e1hl\u00e9 investice do p\u0159\u00edstrojov\u00e9ho vybaven\u00ed, tohle v\u0161echno umo\u017enila spolupr\u00e1ce mezi v\u011bdeck\u00fdmi institucemi pod hlavi\u010dkou N\u00e1rodn\u00edho institutu pro v\u00fdzkum metabolick\u00fdch a […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14161,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-62257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/62257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=62257"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/62257\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14161"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=62257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=62257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=62257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}