Vz\u00e1cnou d\u011bdi\u010dnou chorobu p\u0159edal d\u011btem d\u00e1rce spermatu z D\u00e1nska. Genetick\u00e1 mutace zvy\u0161uje riziko vzniku rakoviny a\u017e na 90 procent. Sperma daroval mu\u017e p\u0159es 17 let a narodilo se d\u00edky n\u011bmu prokazateln\u011b t\u00e9m\u011b\u0159 200 d\u011bt\u00ed nap\u0159\u00ed\u010d Evropou.<\/p>\n\n\n\n
P\u0159ed \u010dtrn\u00e1cti lety d\u00edky um\u011bl\u00e9mu oplodn\u011bn\u00ed ot\u011bhotn\u011bla, letos j\u00ed zavolali l\u00e9ka\u0159i z reproduk\u010dn\u00ed kliniky, aby nechala dceru vy\u0161et\u0159it. Pou\u017eit\u00e9 sperma toti\u017e poch\u00e1zelo od d\u00e1rce s vz\u00e1cnou genetickou vadou. Ta zvy\u0161uje riziko rakoviny a\u017e na 90 procent. \u201eNev\u00edme, kdy to p\u0159ijde, nev\u00edme jak\u00fd druh a nev\u00edme kolikr\u00e1t,\u201c popsala pro britskou stanici BBC \u017eena z Francie.<\/p>\n\n\n\n
Sperma anonymn\u00edho d\u00e1rce prodala Evropsk\u00e1 spermobanka v D\u00e1nsku do 67 klinik ve 14 evropsk\u00fdch zem\u00edch. Podle zji\u0161t\u011bn\u00ed BBC se d\u00edky n\u011bmu narodilo nejm\u00e9n\u011b 197 d\u011bt\u00ed. N\u011bkter\u00e9 z nich u\u017e rakovinou onemocn\u011bly, n\u011bkter\u00e9 na ni dokonce zem\u0159ely.<\/p>\n\n\n\n
Na cel\u00fd p\u0159\u00edpad letos upozornili l\u00e9ka\u0159i, kte\u0159\u00ed si v\u0161imli spojitost\u00ed mezi d\u011btmi s rakovinou a zp\u016fsobem jejich po\u010det\u00ed.<\/p>\n\n\n\n
Vz\u00e1cn\u00e9 onemocn\u011bn\u00ed<\/p>\n\n\n\n
Mu\u017e daroval sperma od roku 2005, pro\u0161el v\u0161emi pot\u0159ebn\u00fdmi kontrolami a s\u00e1m je zdrav\u00fd. V n\u011bkter\u00fdch bu\u0148k\u00e1ch m\u00e1 ale po\u0161kozen\u00fd gen TP53, kter\u00fd br\u00e1n\u00ed vzniku rakoviny. Podle BBC je takto posti\u017een\u00e1 asi p\u011btina jeho spermi\u00ed a ka\u017ed\u00e9 d\u00edt\u011b z nich po\u010dat\u00e9 bude m\u00edt mutaci genu ve v\u0161ech bu\u0148k\u00e1ch v t\u011ble.<\/p>\n\n\n\n
D\u011bdi\u010dn\u00e9 onemocn\u011bn\u00ed zp\u016fsoben\u00e9 mutac\u00ed genu TP53 se naz\u00fdv\u00e1 Li-Fraumeniho syndrom a v\u00fdznamn\u011b zvy\u0161uje riziko rakoviny zejm\u00e9na v d\u011btstv\u00ed, ale i v pozd\u011bj\u0161\u00edm v\u011bku. \u201eJe to pro rodinu extr\u00e9mn\u011b n\u00e1ro\u010dn\u00e1 zpr\u00e1va a celo\u017eivotn\u00ed b\u0159\u00edm\u011b \u017e\u00edt s t\u00edmto rizikem. Jednozna\u010dn\u011b devastuj\u00edc\u00ed,\u201c \u0159ekla pro BBC geneti\u010dka Clare Turnbullov\u00e1.<\/p>\n\n\n\n
Prvn\u00ed varov\u00e1n\u00ed nesta\u010dilo<\/p>\n\n\n\n
Podle z\u00e1stupc\u016f Evropsk\u00e9 spermobanky takovou mutaci preventivn\u00ed genetick\u00e9 screeningy nezachyt\u00ed. D\u00e1rce \u00fadajn\u011b zablokovali hned, jak na probl\u00e9m p\u0159i\u0161li. \u201eTis\u00edce \u017een a p\u00e1r\u016f d\u00edt\u011b bez pomoci d\u00e1rcovsk\u00e9ho spermatu nem\u016f\u017eou m\u00edt. Pokud jsou d\u00e1rci vy\u0161et\u0159ov\u00e1ni podle l\u00e9ka\u0159sk\u00fdch pokyn\u016f, je to i bezpe\u010dn\u011bj\u0161\u00ed,\u201c dodali.<\/p>\n\n\n\n
N\u011bmeck\u00e1 stanice Deutsche Welle nicm\u00e9n\u011b zjistila, \u017ee prvn\u00ed podez\u0159en\u00ed se objevilo u\u017e v roce 2020. Tehdy vy\u0161lo najevo, \u017ee jedno z d\u011bt\u00ed d\u00e1rce m\u00e1 po\u0161kozen\u00e9 geny TP53. Odborn\u00edci sperma otestovali, ale jeliko\u017e se mutace nach\u00e1z\u00ed jen v \u010d\u00e1sti bun\u011bk, probl\u00e9m neodhalili.<\/p>\n\n\n\n
Sperma tak za\u010dali znovu prod\u00e1vat reproduk\u010dn\u00edm klinik\u00e1m a\u017e do roku 2023, kdy se Evropsk\u00e9 spermobance ozvali dal\u0161\u00ed rodi\u010de se stejn\u011b nemocn\u00fdm d\u00edt\u011btem. Dal\u0161\u00ed testy u\u017e mutaci odhalily a banka d\u00e1rce definitivn\u011b vy\u0161krtla ze seznamu.<\/p>\n\n\n\n
N\u011bkte\u0159\u00ed rodi\u010de o probl\u00e9mu nev\u00ed<\/p>\n\n\n\n
Evropsk\u00e1 spermobanka v D\u00e1nsku mus\u00ed podle z\u00e1kona informovat kliniky, kter\u00fdm sperma prodala. Ty zase mus\u00ed zpravit zasa\u017een\u00e9 rodi\u010de. Podle Deutsche Welle se tak ale u n\u011bkter\u00fdch rodin nestalo.<\/p>\n\n\n\n
Zejm\u00e9na u d\u011bt\u00ed je p\u0159itom d\u016fle\u017eit\u00e9, aby jejich pediat\u0159i o p\u0159\u00edpadn\u00e9 mutaci genu TP53 v\u011bd\u011bli. Obecn\u011b je toti\u017e v ran\u00e9m v\u011bku onkologick\u00e9 onemocn\u011bn\u00ed vz\u00e1cn\u00e9 a jeho symptomy tak m\u016f\u017eou l\u00e9ka\u0159i v n\u011bkter\u00fdch p\u0159\u00edpadech podcenit. \u201e\u010c\u00edm d\u0159\u00edve na rakovinu p\u0159ijdou, t\u00edm sn\u00e1z se bude l\u00e9\u010dit,\u201c podotkla podle Deutsche Welle onkolo\u017eka Svetlana Lagercrantzov\u00e1.<\/p>\n\n\n\n
V jak\u00fdch zem\u00edch kliniky prokazateln\u011b vyu\u017eily sperma d\u00e1rce s mutac\u00ed genu TP53:<\/p>\n\n\n\n
Island, Irsko, \u0160pan\u011blsko, Belgie, N\u011bmecko, Polsko, D\u00e1nsko, Ma\u010farsko, Srbsko, Severn\u00ed Makedonie, Alb\u00e1nie, \u0158ecko, Kypr, Gruzie<\/p>\n\n\n\n
D\u011bti se ale mohly narodit rodin\u00e1m i v jin\u00fdch zem\u00edch. V n\u011bkter\u00fdch p\u0159\u00edpadech toti\u017e \u017eeny cestovaly kv\u016fli um\u011bl\u00e9mu oplodn\u011bn\u00ed do zahrani\u010d\u00ed.<\/p>\n\n\n\n
Potvrzen\u00fdch je nap\u0159\u00edklad n\u011bkolik p\u0159\u00edpad\u016f Britek, kter\u00e9 podstoupily l\u00e9\u010dbu neplodnosti s vyu\u017eit\u00edm spermatu dan\u00e9ho d\u00e1rce v D\u00e1nsku.<\/p>\n\n\n\n
Magdal\u00e9na Bla\u017ekov\u00e1<\/p>\n\n\n\n
Den\u00edk.cz<\/p>\n\n\n\n
https:\/\/www.denik.cz<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Vz\u00e1cnou d\u011bdi\u010dnou chorobu p\u0159edal d\u011btem d\u00e1rce spermatu z D\u00e1nska. Genetick\u00e1 mutace zvy\u0161uje riziko vzniku rakoviny a\u017e na 90 procent. Sperma daroval mu\u017e p\u0159es 17 let […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":14128,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-62354","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/62354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=62354"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/62354\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/14128"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=62354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=62354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=62354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}