N\u00e1dor prostaty m\u016f\u017ee souviset s hladinou testosteronu v krvi. V\u00fdzkumn\u00edci z Texask\u00e9 univerzity letos v \u00fanoru zve\u0159ejnili v\u00fdsledky studie, kter\u00e1 nazna\u010duje, \u017ee n\u00edzk\u00e1 hladina testosteronu u mu\u017e\u016f m\u016f\u017ee podporovat agresivn\u00ed rakovinu prostaty. Toto n\u00e1dorov\u00e9 onemocn\u011bn\u00ed je nej\u010dast\u011bj\u0161\u00edm typem rakoviny u mu\u017e\u016f.<\/p>\n\n\n\n
Odhalit rakovinu prostaty nen\u00ed jednoduch\u00e9, proto\u017ee v po\u010d\u00e1te\u010dn\u00edch stadi\u00edch se neprojevuje t\u00e9m\u011b\u0159 \u017e\u00e1dn\u00fdmi symptomy. Zat\u00edmco u v\u011bt\u0161iny pacient\u016f se vyskytuj\u00ed pomalu rostouc\u00ed n\u00e1dory, asi deset procent posti\u017een\u00fdch trp\u00ed agresivn\u00ed formou onemocn\u011bn\u00ed, a to je velmi v\u00e1\u017en\u00fd stav. Tento vysoce rizikov\u00fd karcinom se toti\u017e rychle \u0161\u00ed\u0159\u00ed do dal\u0161\u00edch org\u00e1n\u016f.<\/p>\n\n\n\n
N\u00e1dor prostaty metast\u00e1zuje nej\u010dast\u011bji p\u0159es lymfatick\u00e9 uzliny do kost\u00ed, plic, jater, nervov\u00e9 soustavy \u010di ledvin. \u201eRakovina prostaty m\u016f\u017ee b\u00fdt \u017eivot ohro\u017euj\u00edc\u00ed, pokud se roz\u0161\u00ed\u0159\u00ed daleko za hranice prostaty,\u201c uv\u00e1d\u00ed Den\u00edk.<\/p>\n\n\n\n
Posledn\u00ed v\u011bdeck\u00e9 v\u00fdzkumy v\u0161ak nazna\u010duj\u00ed, \u017ee mo\u017enost v\u00fdvoje n\u00e1doru prostaty do agresivn\u00ed formy souvis\u00ed s n\u00edzkou hladinou testosteronu u pacienta.<\/p>\n\n\n\n
N\u00e1dor m\u016f\u017ee ovlivnit hladina testosteronu<\/p>\n\n\n\n
V\u00fdzkumn\u00edci z univerzity v Texasu ned\u00e1vno zve\u0159ejnili studii, podle n\u00ed\u017e pr\u00e1v\u011b n\u00edzk\u00e9 hladiny testosteronu mohou podporovat agresivn\u00ed rakovinu prostaty. V r\u00e1mci t\u00e9to studie v\u011bdci v letech 2001 a\u017e 2024 sledovali 924 mu\u017e\u016f a jejich hladinu testosteronu.<\/p>\n\n\n\n
Testosteron je hormon, kter\u00fd produkuj\u00ed varlata i vaje\u010dn\u00edky. Nadledviny nav\u00edc vytv\u00e1\u0159ej\u00ed hormon dehydroepiandrosteron (DHEA), kter\u00fd lidsk\u00e9 t\u011blo p\u0159em\u011b\u0148uje na testosteron a estrogen.<\/p>\n\n\n\n
Testosteron je hlavn\u00ed androgen, co\u017e znamen\u00e1, \u017ee stimuluje rozvoj mu\u017esk\u00fdch charakteristik. Hladiny testosteronu jsou tak p\u0159irozen\u011b mnohem vy\u0161\u0161\u00ed u mu\u017e\u016f ne\u017e u \u017een.<\/p>\n\n\n\n
\u201eP\u0159irozen\u00fd testosteron je steroid \u2013 anabolicko-androgenn\u00ed steroid. ,Anabolick\u00fd\u2019 ozna\u010duje budov\u00e1n\u00ed sval\u016f a ,androgenn\u00ed\u2019 znamen\u00e1 zv\u00fd\u0161en\u00ed mu\u017esk\u00fdch pohlavn\u00edch znak\u016f,\u201c vysv\u011btluj\u00ed l\u00e9ka\u0159i z Clevelandsk\u00e9 kliniky.<\/p>\n\n\n\n
U dosp\u011bl\u00fdch mu\u017e\u016f se norm\u00e1ln\u00ed hladina koncentrace testosteronu v krvi obvykle pohybuje mezi 240 \u2013 950 nanogramy na decilitr. Hodnoty se m\u011bn\u00ed podle v\u011bku i denn\u00ed doby Pokud hladina klesne pod 300 ng\/dl, ozna\u010duje se jako n\u00edzk\u00e1.<\/p>\n\n\n\n
Studie texask\u00fdch v\u011bdc\u016f upozornila, \u017ee mu\u017ei s rakovinou prostaty, jejich\u017e hladina testosteronu klesla pod 300 ng\/dl, maj\u00ed o 60 procent vy\u0161\u0161\u00ed pravd\u011bpodobnost, \u017ee se u nich rakovina prostaty rozvine do t\u0159et\u00edho nebo vy\u0161\u0161\u00edho st\u00e1dia. N\u00e1dory v t\u00e9to kategorii jsou pova\u017eov\u00e1ny za agresivn\u00ed.<\/p>\n\n\n\n
\u201eN\u00edzk\u00e9 hladiny testosteronu m\u011bly v\u011bt\u0161\u00ed vliv na riziko vzniku agresivn\u00edho karcinomu ne\u017e jin\u00e9 faktory, jako je v\u011bk, index t\u011blesn\u00e9 hmotnosti (BMI), prostatick\u00fd specifick\u00fd antigen \u010di velikost a hustota n\u00e1doru,\u201c konstatovali v\u00fdzkumn\u00edci.<\/p>\n\n\n\n
N\u00e1pov\u011bda pro l\u00e9ka\u0159e<\/p>\n\n\n\n
Podle autor\u016f v\u00fdsledky studie neprokazuj\u00ed, \u017ee n\u00edzk\u00e9 hladiny testosteronu zp\u016fsobuj\u00ed agresivn\u00ed rakovinu. Pouze odhaluj\u00ed souvislost, kter\u00e1 m\u016f\u017ee podpo\u0159it monitorov\u00e1n\u00ed nemoci a rozhodov\u00e1n\u00ed o l\u00e9\u010db\u011b.<\/p>\n\n\n\n
Pro pacienty trp\u00edc\u00ed rakovinou prostaty je to v\u0161ak dobr\u00e1 zpr\u00e1va, proto\u017ee podle stavu testoteronu by mohli l\u00e9ka\u0159i odhadnout, jak by se mohla jejich nemoc vyv\u00edjet.<\/p>\n\n\n\n
\u201ePochopen\u00ed vlivu hormon\u00e1ln\u00edch faktor\u016f na biologii rakoviny prostaty n\u00e1m m\u016f\u017ee pomoci optimalizovat strategie sledov\u00e1n\u00ed,\u201c uvedl v tiskov\u00e9 zpr\u00e1v\u011b spoluautor studie Justin R. Gregg.<\/p>\n\n\n\n
Dodal, \u017ee identifikace pacient\u016f se zv\u00fd\u0161en\u00fdm rizikem progrese onemocn\u011bn\u00ed z\u016fst\u00e1v\u00e1 pro l\u00e9ka\u0159e kl\u00ed\u010dovou v\u00fdzvou. Budouc\u00ed v\u00fdzkum by se v\u0161ak podle n\u011bj m\u011bl zam\u011b\u0159it na objasn\u011bn\u00ed biologick\u00e9ho vztahu mezi androgeny a progres\u00ed rakoviny prostaty.<\/p>\n\n\n\n
Nej\u010dast\u011bj\u0161\u00ed onkologick\u00fd probl\u00e9m \u010desk\u00fdch mu\u017e\u016f<\/p>\n\n\n\n
V \u010cesk\u00e9 republice je rakovina prostaty nej\u010dast\u011bj\u0161\u00edm onkologick\u00fdm probl\u00e9mem mu\u017e\u016f. Ka\u017ed\u00fd rok je diagnostikov\u00e1na p\u0159ibli\u017en\u011b u 8100 pacient\u016f. Je to t\u00e9m\u011b\u0159 t\u0159ikr\u00e1t v\u00edce ne\u017e p\u0159ed p\u011btadvaceti lety. P\u0159ibli\u017en\u011b 1400 mu\u017e\u016f v \u010cR ro\u010dn\u011b na rakovinu prostaty um\u00edr\u00e1.<\/p>\n\n\n\n
Rakovina prostaty je t\u0159et\u00ed nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinnou \u00famrt\u00ed na zhoubn\u00fd n\u00e1dor u \u010desk\u00fdch mu\u017e\u016f.<\/p>\n\n\n\n
Prostata je mal\u00e1 \u017el\u00e1za, kter\u00e1 obklopuje horn\u00ed \u010d\u00e1st mu\u017esk\u00e9 mo\u010dov\u00e9 trubice. Je um\u00edst\u011bna t\u011bsn\u011b pod hrdlem mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e a svou zadn\u00ed plochou nal\u00e9h\u00e1 na st\u011bnu kone\u010dn\u00edku. \u00dalohou prostaty je tvorba tekutiny, kter\u00e1 je sou\u010d\u00e1st\u00ed ejakul\u00e1tu, kde podporuje transport spermi\u00ed.<\/p>\n\n\n\n
Zachytit rakovinu prostaty v \u010dasn\u00e9m stadiu je velmi obt\u00ed\u017en\u00e9. Pokud se karcinom z prostaty roz\u0161\u00ed\u0159\u00ed i do dal\u0161\u00edch org\u00e1n\u016f, ocit\u00e1 se pacient ve v\u00e1\u017en\u00e9m nebezpe\u010d\u00ed.<\/p>\n\n\n\n
V \u010cesk\u00e9 republice byl proto p\u0159ed dv\u011bma lety zah\u00e1jen screening, kter\u00fd pom\u00e1h\u00e1 zachytit toto onemocn\u011bn\u00ed v \u010dasn\u00e9m a velmi dob\u0159e l\u00e9\u010diteln\u00e9m st\u00e1diu.<\/p>\n\n\n\n
Ivana Vitovsk\u00e1<\/p>\n\n\n\n
Den\u00edk.cz<\/p>\n\n\n\n
https:\/\/www.denik.cz<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" N\u00e1dor prostaty m\u016f\u017ee souviset s hladinou testosteronu v krvi. V\u00fdzkumn\u00edci z Texask\u00e9 univerzity letos v \u00fanoru zve\u0159ejnili v\u00fdsledky studie, kter\u00e1 nazna\u010duje, \u017ee n\u00edzk\u00e1 hladina testosteronu […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":39424,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-63724","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/63724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63724"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/63724\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/39424"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}