Fakultn\u00ed nemocnice Plze\u0148 jako prvn\u00ed na sv\u011bt\u011b kombinuje radiofarmakum 68Ga-Trivehexin s vy\u0161et\u0159en\u00edm PET\/MRI pro diagnostiku onkologick\u00fdch onemocn\u011bn\u00ed. Nov\u00e1 metoda umo\u017e\u0148uje p\u0159esn\u011bj\u0161\u00ed zobrazen\u00ed n\u00e1dor\u016f a lep\u0161\u00ed rozli\u0161en\u00ed n\u00e1dorov\u00e9 a z\u00e1n\u011btliv\u00e9 tk\u00e1n\u011b, co\u017e p\u0159edstavuje z\u00e1sadn\u00ed pokrok zejm\u00e9na u rakoviny slinivky.<\/p>\n\n\n\n
Fakultn\u00ed nemocnice Plze\u0148 (FN) za\u010dala pou\u017e\u00edvat novou metodu zobrazov\u00e1n\u00ed n\u00e1dor\u016f a diagnostiky onkologick\u00fdch onemocn\u011bn\u00ed. Kombinace radiofarmaka 68Ga-Trivehexin a vy\u0161et\u0159en\u00ed p\u0159\u00edstrojem PET\/MRI, kter\u00fd kombinuje pozitronovou emisn\u00ed tomografii a magnetickou rezonanci, vyu\u017e\u00edv\u00e1 nemocnice podle jej\u00edho \u0159editele V\u00e1clava \u0160im\u00e1nka jako prvn\u00ed na sv\u011bt\u011b.<\/p>\n\n\n\n
Metoda poskytuje p\u0159esn\u011bj\u0161\u00ed zobrazen\u00ed n\u00e1dor\u016f, lep\u0161\u00ed rozli\u0161en\u00ed n\u00e1dorov\u00e9 a z\u00e1n\u011btliv\u00e9 tk\u00e1n\u011b a informace pro pl\u00e1nov\u00e1n\u00ed operac\u00ed. Nov\u00fd postup je dal\u0161\u00edm krokem v rozvoji personalizovan\u00e9 onkologick\u00e9 diagnostiky a m\u016f\u017ee v\u00fdznamn\u011b pomoci zejm\u00e9na pacient\u016fm s n\u00e1dory slinivky, ale tak\u00e9 plic, hlavy a krku, \u0159ekla mluv\u010d\u00ed FN Gabriela Levorov\u00e1.<\/p>\n\n\n\n
L\u00e1tka se c\u00edlen\u011b v\u00e1\u017ee na specifick\u00e9 receptory<\/p>\n\n\n\n
Radiofarmakum 68Ga-Trivehexin pat\u0159\u00ed mezi l\u00e1tky, kter\u00e9 se c\u00edlen\u011b v\u00e1\u017eou na specifick\u00e9 receptory na povrchu n\u011bkter\u00fdch n\u00e1dorov\u00fdch bun\u011bk a l\u00e9pe zobraz\u00ed n\u00e1dorovou tk\u00e1\u0148 a odli\u0161\u00ed ji od okoln\u00edho z\u00e1n\u011btu. Podle \u0160im\u00e1nka s t\u00edmto radiofarmakem pracuje na sv\u011bt\u011b jen n\u011bkolik specializovan\u00fdch pracovi\u0161\u0165. \u201eFN Plze\u0148 je v\u0161ak prvn\u00ed, kter\u00e1 jej vyu\u017e\u00edv\u00e1 v kombinaci s PET\/MRI. A pr\u00e1v\u011b tato kombinace umo\u017e\u0148uje na\u0161im l\u00e9ka\u0159\u016fm z\u00edskat informace o biologick\u00e9 aktivit\u011b n\u00e1doru a sou\u010dasn\u011b velmi podrobn\u00e9 zobrazen\u00ed okoln\u00edch tk\u00e1n\u00ed,“ uvedl.<\/p>\n\n\n\n
Receptor si lze p\u0159edstavit jako pomysln\u00fd z\u00e1mek na povrchu bu\u0148ky, do kter\u00e9ho zapadne jen spr\u00e1vn\u00fd kl\u00ed\u010d. \u201eT\u00edm je v tomto p\u0159\u00edpad\u011b speci\u00e1ln\u00ed l\u00e1tka, kter\u00e1 se na receptor nav\u00e1\u017ee a umo\u017en\u00ed l\u00e9ka\u0159\u016fm n\u00e1dorovou tk\u00e1\u0148 zobrazit,“ popsal princip p\u0159ednosta Kliniky zobrazovac\u00edch metod Ji\u0159\u00ed Ferda.<\/p>\n\n\n\n
P\u0159esn\u00e9 rozli\u0161en\u00ed n\u00e1doru a z\u00e1n\u011btu p\u0159edstavuje p\u0159i diagnostice rakoviny slinivky jeden z nejv\u011bt\u0161\u00edch probl\u00e9m\u016f. N\u00e1dor toti\u017e \u010dasto vyvol\u00e1v\u00e1 z\u00e1n\u011btlivou reakci okoln\u00ed tk\u00e1n\u011b, kter\u00e1 m\u016f\u017ee komplikovat p\u0159esn\u00e9 ur\u010den\u00ed rozsahu onemocn\u011bn\u00ed. Na rozd\u00edl od n\u011bkter\u00fdch b\u011b\u017en\u011b pou\u017e\u00edvan\u00fdch radiofarmak se 68Ga-Trivehexin nevychyt\u00e1v\u00e1 v z\u00e1n\u011btliv\u011b aktivovan\u00fdch b\u00edl\u00fdch krvink\u00e1ch, tak\u017ee p\u0159\u00edstroj pak dok\u00e1\u017ee l\u00e9pe zobrazit n\u00e1dor, jeho rozsah \u010di p\u0159\u00edpadn\u00e9 posti\u017een\u00ed m\u00edzn\u00edch uzlin.<\/p>\n\n\n\n
P\u0159esn\u011bj\u0161\u00ed posouzen\u00ed a lep\u0161\u00ed pl\u00e1nov\u00e1n\u00ed z\u00e1kroku<\/p>\n\n\n\n
Radiofarmakum p\u0159ipravuj\u00ed ve FN Plze\u0148 specialist\u00e9. Pacient dostane l\u00e1tku nitro\u017eiln\u011b a ta se do hodiny nav\u00e1\u017ee na p\u0159\u00edslu\u0161n\u00e9 receptory v t\u011ble. Nemocn\u00fd pak absolvuje vy\u0161et\u0159en\u00ed PET\/MRI. L\u00e9ka\u0159i mohou p\u0159esn\u011bji posoudit rozsah n\u00e1dorov\u00e9ho onemocn\u011bn\u00ed a detailn\u011bji napl\u00e1novat i prov\u00e9st chirurgick\u00fd z\u00e1krok.<\/p>\n\n\n\n
\u201eRadiofarmakum dosud nem\u00e1 b\u011b\u017enou registraci l\u00e9\u010div\u00e9ho p\u0159\u00edpravku, jeho pou\u017eit\u00ed proto podl\u00e9h\u00e1 zvl\u00e1\u0161tn\u00edmu schvalovac\u00edmu re\u017eimu, na kter\u00e9m se pod\u00edlej\u00ed St\u00e1tn\u00ed \u00fastav pro kontrolu l\u00e9\u010div a Ministerstvo zdravotnictv\u00ed \u010cR,“ doplnil Ferda.<\/p>\n\n\n\n
Rakovina slinivky v \u010cR<\/p>\n\n\n\n
Po\u010det nemocn\u00fdch rakovinou slinivky v \u010cR se podle dat onkologick\u00e9ho registru za 30 let v\u00edce ne\u017e zdvojn\u00e1sobil, p\u0159edloni jich bylo 2694. Na tento typ rakoviny p\u0159edloni zem\u0159elo 2351 lid\u00ed. V \u010cR jen \u0161est procent nemocn\u00fdch p\u0159e\u017eije d\u00e9le ne\u017e p\u011bt let od chv\u00edle, kdy se u nich diagn\u00f3za potvrd\u00ed. Podle l\u00e9ka\u0159\u016f je to hlavn\u011b kv\u016fli tomu, \u017ee se u nich na n\u00e1dor p\u0159i\u0161lo pozd\u011b.<\/p>\n\n\n\n
\u010cTK<\/p>\n\n\n\n
Plze\u0148sk\u00fd den\u00edk<\/p>\n\n\n\n
https:\/\/plzensky.denik.cz<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Fakultn\u00ed nemocnice Plze\u0148 jako prvn\u00ed na sv\u011bt\u011b kombinuje radiofarmakum 68Ga-Trivehexin s vy\u0161et\u0159en\u00edm PET\/MRI pro diagnostiku onkologick\u00fdch onemocn\u011bn\u00ed. Nov\u00e1 metoda umo\u017e\u0148uje p\u0159esn\u011bj\u0161\u00ed zobrazen\u00ed n\u00e1dor\u016f a lep\u0161\u00ed […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":31583,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-65461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/65461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=65461"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/65461\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/31583"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=65461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=65461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=65461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}