Nov\u00e1 c\u00edlen\u00e1 l\u00e9\u010dba p\u0159in\u00e1\u0161\u00ed pacient\u016fm nad\u011bji
<\/p>\n\n\n\n
Lid\u00e9 s rakovinou slinivky b\u0159i\u0161n\u00ed bojuj\u00ed doslova o ka\u017ed\u00fd dal\u0161\u00ed den. Nemoc pat\u0159\u00ed k n\u00e1dor\u016fm s nejhor\u0161\u00ed progn\u00f3zou. O to intenzivn\u011bji se o\u010di l\u00e9ka\u0159\u016f up\u00edraj\u00ed na z\u00e1pad, kde v\u011bdci zkoumaj\u00ed l\u00e9\u010dbu, kter\u00e1 by mohla osudy t\u011bchto pacient\u016f zm\u011bnit. Na pokrok i jeho sou\u010dasn\u00e9 limity upozor\u0148uj\u00ed gastroenterologov\u00e9 p\u0159i p\u0159\u00edle\u017eitosti Sv\u011btov\u00e9ho dne rakoviny slinivky, kter\u00fd letos p\u0159ipad\u00e1 na 19. listopadu.<\/p>\n\n\n\n
\u201eZat\u00edm nejd\u00e1l je l\u00e9k na b\u00e1zi \u00fa\u010dinn\u00e9 l\u00e1tky daraxonrasib. Ten c\u00edlen\u011b blokuje b\u00edlkovinu, kter\u00e1 u v\u011bt\u0161iny n\u00e1dor\u016f slinivky b\u0159i\u0161n\u00ed funguje jako zaseknut\u00fd plynov\u00fd ped\u00e1l a podporuje nekontrolovan\u00fd r\u016fst bun\u011bk. Tento l\u00e9k se zat\u00edm nasazoval lidem ve IV., metastatick\u00e9m stadiu. V klinick\u00e9 f\u00e1zi prodlou\u017eil medi\u00e1n do\u017eit\u00ed pacient\u016f z 6,7 m\u011bs\u00edce p\u0159i standardn\u00ed chemoterapii na 13,2 m\u011bs\u00edce, tedy t\u00e9m\u011b\u0159 dvojn\u00e1sobn\u011b,\u201c \u0159\u00edk\u00e1 prof. MUDr. Ond\u0159ej Urban, p\u0159ednosta II. intern\u00ed kliniky \u2013 gastroenterologick\u00e9 a geriatrick\u00e9 Fakultn\u00ed nemocnice Olomouc. L\u00e9k 26. srpna 2026 schv\u00e1lil Americk\u00fd \u00fa\u0159ad pro kontrolu potravin a l\u00e9\u010div, jeho schv\u00e1len\u00ed pro evropsk\u00e9 pacienty doporu\u010dila Evropsk\u00e1 agentura pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky. \u201eNyn\u00ed se \u010dek\u00e1 na rozhodnut\u00ed Evropsk\u00e9 komise. Dostupnost v \u010cesku bude z\u00e1viset tak\u00e9 na stanoven\u00ed ceny a \u00fahrady. L\u00e9k je drah\u00fd a cena se pohybuje kolem milionu korun na jednoho pacienta za m\u011bs\u00edc,\u201c dopl\u0148uje prof. Urban.<\/p>\n\n\n\n
Nad\u011bji do budoucna p\u0159in\u00e1\u0161\u00ed tak\u00e9 v\u00fdvoj vakc\u00edny, kter\u00e1 by mohla vzniku rakoviny slinivky b\u0159i\u0161n\u00ed dokonce p\u0159edch\u00e1zet. Ameri\u010dt\u00ed v\u011bdci z Johns Hopkins University zkoumaj\u00ed experiment\u00e1ln\u00ed o\u010dkovac\u00ed l\u00e1tku, kter\u00e1 u\u010d\u00ed imunitn\u00ed syst\u00e9m rozpoznat a zni\u010dit nebezpe\u010dn\u00e9 bu\u0148ky d\u0159\u00edve, ne\u017e se z nich vyvine n\u00e1dor. Zam\u011b\u0159uje se na zm\u011bny v genu KRAS, kter\u00e9 se vyskytuj\u00ed u v\u00edce ne\u017e 90 % n\u00e1dor\u016f slinivky. Ve studii f\u00e1ze I tato l\u00e1tka vyvolala imunitn\u00ed odpov\u011b\u010f u 18 z 20 \u00fa\u010dastn\u00edk\u016f s d\u011bdi\u010dnou predispozic\u00ed a zm\u011bnou na slinivce zji\u0161t\u011bnou zobrazovac\u00edm vy\u0161et\u0159en\u00edm. <\/p>\n\n\n\n
\u201eV\u00fdsledky jsou povzbudiv\u00e9, ale preventivn\u00ed \u00fa\u010dinek mus\u00ed ov\u011b\u0159it v\u011bt\u0161\u00ed studie s del\u0161\u00edm sledov\u00e1n\u00edm. Pokud by se v\u0161ak \u00fa\u010dinnost l\u00e1tky prok\u00e1zala, pak by mohla pom\u00e1hat p\u0159edev\u0161\u00edm lidem s vysok\u00fdm d\u011bdi\u010dn\u00fdm rizikem onemocn\u011bn\u00ed. Um\u00edm si p\u0159edstavit, \u017ee by z n\u00ed v budoucnosti profitovali nap\u0159\u00edklad ti, kter\u00e9 v r\u00e1mci programu c\u00edlen\u00e9ho vyhled\u00e1v\u00e1n\u00ed karcinomu pankreatu pravideln\u011b vy\u0161et\u0159ujeme,\u201c vysv\u011btluje prof. Urban.<\/p>\n\n\n\n
Dal\u0161\u00ed sm\u011br v\u00fdzkumu p\u0159edstavuje pr\u00e1ce t\u00fdmu Mariana Barbacida z madridsk\u00e9ho N\u00e1rodn\u00edho centra pro v\u00fdzkum rakoviny. \u0160pan\u011blsk\u00fdm v\u011bdc\u016fm se poda\u0159ilo kombinac\u00ed daraxonrasibu, afatinibu a experiment\u00e1ln\u00ed l\u00e1tky SD36 dos\u00e1hnout \u00fastupu n\u00e1dor\u016f u n\u011bkter\u00fdch laboratorn\u00edch my\u0161\u00ed. \u201eV\u00fdsledek u zv\u00ed\u0159at ale je\u0161t\u011b nezaru\u010duje \u00fa\u010dinnost ani bezpe\u010dnost u \u010dlov\u011bka. P\u0159ed p\u0159\u00edpadn\u00fdm pou\u017eit\u00edm t\u00e9to kombinace u pacient\u016f bude nutn\u00fd dal\u0161\u00ed v\u00fdvoj a klinick\u00e9 ov\u011b\u0159en\u00ed,\u201c upozor\u0148uje prof. MUDr. Ilja Tachec\u00ed, p\u0159edseda \u010cesk\u00e9 gastroenterologick\u00e9 spole\u010dnosti a p\u0159ednosta II. intern\u00ed gastroenterologick\u00e9 kliniky FN Hradec Kr\u00e1lov\u00e9.<\/p>\n\n\n\n
P\u0159ipom\u00edn\u00e1, \u017ee rakovina slinivky zpo\u010d\u00e1tku \u010dasto prob\u00edh\u00e1 bez n\u00e1padn\u00fdch p\u0159\u00edznak\u016f a n\u00e1dor lze operovat jen u men\u0161iny nemocn\u00fdch. \u201eNem\u011bli bychom podce\u0148ovat nov\u011b vzniklou \u017eloutenku, nevysv\u011btliteln\u00e9 hubnut\u00ed ani p\u0159etrv\u00e1vaj\u00edc\u00ed bolesti b\u0159icha \u010di zad. S l\u00e9ka\u0159em je vhodn\u00e9 probrat tak\u00e9 nov\u011b vzniklou cukrovku po pades\u00e1tce, zvl\u00e1\u0161t\u011b p\u0159i sou\u010dasn\u00e9m necht\u011bn\u00e9m hubnut\u00ed. U naprost\u00e9 v\u011bt\u0161iny pacient\u016f v\u0161ak cukrovka nen\u00ed zp\u016fsobena n\u00e1dorem,\u201c \u0159\u00edk\u00e1 prof. Tachec\u00ed.<\/p>\n\n\n\n
Lid\u00e9, v jejich\u017e rodin\u011b se rakovina slinivky b\u0159i\u0161n\u00ed vyskytla opakovan\u011b, nebo ti, kte\u0159\u00ed jsou nositeli d\u011bdi\u010dn\u00e9 mutace zvy\u0161uj\u00edc\u00ed riziko tohoto onemocn\u011bn\u00ed, by m\u011bli s l\u00e9ka\u0159em konzultovat mo\u017enost pravideln\u00e9ho sledov\u00e1n\u00ed ve specializovan\u00e9m centru. Riziko vzniku n\u00e1doru lze z\u00e1rove\u0148 sn\u00ed\u017eit t\u00edm, \u017ee \u010dlov\u011bk nekou\u0159\u00ed a udr\u017euje si zdravou t\u011blesnou hmotnost.<\/p>\n\n\n\n
V \u010cesku l\u00e9ka\u0159i ka\u017edoro\u010dn\u011b diagnostikuj\u00ed rakovinu slinivky p\u0159ibli\u017en\u011b 2 500 lidem. Podle \u010cesk\u00e9ho statistick\u00e9ho \u00fa\u0159adu zem\u0159elo v roce 2024 na zhoubn\u00fd n\u00e1dor slinivky 2 351 osob.<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Nov\u00e1 c\u00edlen\u00e1 l\u00e9\u010dba p\u0159in\u00e1\u0161\u00ed pacient\u016fm nad\u011bji Lid\u00e9 s rakovinou slinivky b\u0159i\u0161n\u00ed bojuj\u00ed doslova o ka\u017ed\u00fd dal\u0161\u00ed den. Nemoc pat\u0159\u00ed k n\u00e1dor\u016fm s nejhor\u0161\u00ed progn\u00f3zou. O […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":46976,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-65773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zdravi"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/65773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=65773"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/65773\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/media\/46976"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=65773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=65773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=65773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}