{"id":9437,"date":"2013-08-21T10:30:02","date_gmt":"2013-08-21T08:30:02","guid":{"rendered":"http:\/\/www.invarena.cz\/?p=9437"},"modified":"2014-10-20T20:07:00","modified_gmt":"2014-10-20T18:07:00","slug":"biologicka-lecba-je-sice-draha-ale-mimoradne-ucinna","status":"publish","type":"post","link":"https:\/\/www.invarena.cz\/?p=9437","title":{"rendered":"Biologick\u00e1 l\u00e9\u010dba je sice drah\u00e1, ale mimo\u0159\u00e1dn\u011b \u00fa\u010dinn\u00e1"},"content":{"rendered":"

Biologick\u00e1 l\u00e9\u010dba je drah\u00e1, ale \u010dasto jedin\u00e1 mo\u017en\u00e1. Podle v\u00fdrobc\u016f l\u00e9\u010div pr\u00e1v\u011b t\u011bmto l\u00e9k\u016fm pat\u0159\u00ed budoucnost. Ve v\u00fdvoji je moment\u00e1ln\u011b v\u00edce ne\u017e 900 nov\u00fdch biologick\u00fdch l\u00e9k\u016f, z toho t\u0159etina na n\u00e1dory.<\/strong>
\n
\n\u0160estat\u0159icetilet\u00fd Jan Tr\u00e1vn\u00ed\u010dek je teprve \u010dtvrt\u00fdm \u010cechem, kter\u00fd stanul na nejz\u00e1ludn\u011bj\u0161\u00ed osmitis\u00edcovce sv\u011bta \u2013 Annapurn\u011b. Za t\u00fdden vyr\u00e1\u017e\u00ed op\u011bt na expedici. C\u00edlem je dal\u0161\u00ed osmitis\u00edcovka K2. V termosce si p\u0159itom poveze m\u00edsto \u010daje pon\u011bkud nezvyklou v\u00fdbavu horolezce: ampulky s biologick\u00fdm l\u00e9kem, kter\u00fdm si l\u00e9\u010d\u00ed revmatoidn\u00ed artritidu, nemoc, je\u017e zp\u016fsobuje deformaci kloub\u016f.<\/p>\n

„Jen d\u00edky t\u011bm l\u00e9k\u016fm chod\u00edm a m\u016f\u017eu sportovat, tak se o n\u011b pe\u010dliv\u011b star\u00e1m. Maj\u00ed b\u00fdt ulo\u017eeny v teplot\u00e1ch okolo \u0161esti stup\u0148\u016f, ale na expedic\u00edch se \u010dasto pohybujeme v minus dvaceti, tak je holt izoluju od zimy termoskou,“ \u0159\u00edk\u00e1.<\/p>\n

Od v\u00fdroby v\u016fbec prvn\u00edho biologick\u00e9ho l\u00e9ku v t\u011bchto dnech uplynulo pr\u00e1v\u011b 35 let. Kdy\u017e Tr\u00e1vn\u00ed\u010dek ukazuje sv\u00e9 fotografie z doby p\u0159ed za\u010d\u00e1tkem l\u00e9\u010dby, kde m\u00e1 jednu nohu dvojn\u00e1sobn\u011b \u0161irokou oproti t\u00e9 druh\u00e9 a pokroucen\u00e9 otekl\u00e9 prsty na rukou, vypad\u00e1 dnes jako chod\u00edc\u00ed reklama na biologickou l\u00e9\u010dbu.<\/p>\n

„Nesev\u0159el jsem ani ruku v p\u011bst. To se zm\u011bnilo prakticky z hodiny na hodinu hned po prvn\u00ed injekci, tak\u017ee jsem p\u016fl roku nato mohl vyrazit na osmitis\u00edcovku Gasherbrum,“ vypr\u00e1v\u00ed. L\u00e9\u010dit se bude cel\u00fd \u017eivot, co\u017e je hodn\u011b drah\u00e9. Biologika na revmatoidn\u00ed artritidu p\u0159ijdou na 300 tis\u00edc ro\u010dn\u011b.<\/p>\n

„Pacienta nevyl\u00e9\u010d\u00ed, ale umo\u017en\u00ed ho udr\u017eovat ve stavu, kdy se choroba neprojevuje. \u0158\u00edk\u00e1me tomu, \u017ee nemoc je v remisi,“ popsal Karel Pavelka z Revmatologick\u00e9ho \u00fastavu, jednoho z pades\u00e1ti center v zemi, kde l\u00e9ka\u0159i sm\u011bj\u00ed p\u0159edepisovat n\u00e1kladnou biologickou l\u00e9\u010dbu. Tyto l\u00e9ky toti\u017e jsou drah\u00e9 kv\u016fli mechanismu sv\u00e9ho vzniku, kter\u00fd byl ocen\u011bn Nobelovou cenou.<\/p>\n

„Nejde o m\u00edch\u00e1n\u00ed chemick\u00fdch slou\u010denin jako u ostatn\u00edch l\u00e9\u010div. Biologika vyr\u00e1b\u011bj\u00ed \u017eiv\u00e9 organismy v bioreaktoru,“ vysv\u011btluje Jan Strojil z \u00dastavu farmakologie Univerzity Palack\u00e9ho v Olomouci.<\/p>\n

Jde vlastn\u011b o slo\u017eit\u00e9 molekuly vy\u0161lecht\u011bn\u00fdch b\u00edlkovin, kter\u00e9 se um\u011bj\u00ed nav\u00e1zat na konkr\u00e9tn\u00ed bu\u0148ky v t\u011ble a donut\u00ed je zm\u011bnit se. Pod mikroskopem podle Jana Strojila biologick\u00e9 l\u00e9ky vypadaj\u00ed jako zm\u011b\u0165 zmuchlan\u00fdch \u0161\u0148\u016frek, podobn\u011b jako kdy\u017e se v kapse pomotaj\u00ed dr\u00e1tky od sluch\u00e1tek k MP3 p\u0159ehr\u00e1va\u010di.<\/p>\n

Nejv\u00edc l\u00e9k\u016f se vyv\u00edj\u00ed na rakovinu<\/strong><\/p>\n

Biologika l\u00e9\u010d\u00ed nap\u0159\u00edklad tak, \u017ee ozna\u010d\u00ed v t\u011ble rakovinn\u00e9 bu\u0148ky a imunitn\u00ed syst\u00e9m pacienta je pak d\u00edky tomu m\u016f\u017ee snadno zne\u0161kodnit. „Nebo br\u00e1n\u00ed r\u016fstu a mno\u017een\u00ed bun\u011bk, tak\u017ee se n\u00e1dor ne\u0161\u00ed\u0159\u00ed,“ popisuje Jan Strojil.<\/p>\n

Tak\u00e9 mohou fungovat jako jak\u00fdsi posl\u00ed\u010dek \u2013 b\u00fdt nosi\u010dem jin\u00fdch l\u00e9k\u016f, kter\u00e9 doprav\u00ed p\u0159\u00edmo do centra nemoci. Nen\u00ed divu, \u017ee nejv\u011bt\u0161\u00ed d\u00edl z dnes vyv\u00edjen\u00fdch biologick\u00fdch l\u00e9k\u016f bude l\u00e9\u010dit pr\u00e1v\u011b n\u00e1dory.<\/p>\n

Podle Jakuba Dvo\u0159\u00e1\u010dka, \u0161\u00e9fa Asociace v\u00fdrobc\u016f inovativn\u00edho pr\u016fmyslu, je ve v\u00fdvoji p\u0159es 900 t\u011bchto l\u00e9k\u016f. „Z toho 338 na l\u00e9\u010dbu n\u00e1dor\u016f a celkem 89 vakc\u00edn,“ \u0159\u00edk\u00e1. Na trh by se mohly dostat b\u011bhem \u0161esti sedmi let. Dal\u0161\u00ed nemoci, kter\u00e9 maj\u00ed biologika l\u00e9\u010dit, jsou infekce, nemoci krve a k\u016f\u017ee, ale t\u0159eba taky cukrovka. Ostatn\u011b prvn\u00edm biologick\u00fdm l\u00e9kem byl pr\u00e1v\u011b lidsk\u00fd inzulin a vznikl p\u0159ed p\u011btat\u0159iceti lety.<\/p>\n

Pro \u0159adu chorob je biologick\u00e1 l\u00e9\u010dba jedin\u00e1 mo\u017en\u00e1, u ostatn\u00edch nemoc\u00ed nastupuje tehdy, kdy\u017e klasick\u00e9 l\u00e9ky selhaly. Sv\u00e9 o tom v\u00ed obvodn\u00ed l\u00e9ka\u0159ka Libu\u0161e Mikol\u00e1\u0161ov\u00e1. S revmatoidn\u00ed artritidou \u017eije u\u017e p\u011btadvacet let. A i p\u0159es l\u00e9\u010dbu se jej\u00ed stav st\u00e1le zhor\u0161oval.<\/p>\n

„M\u00e1m za sebou deset operac\u00ed, nemoc toti\u017e vyvolala dal\u0161\u00ed p\u0159idru\u017een\u00e9 komplikace. Byla jsem na tom tak, \u017ee zip u kalhot mi musel zap\u00ednat man\u017eel, moje ruce to nedok\u00e1zaly,“ vypr\u00e1v\u00ed. Posledn\u00ed a jedinou \u0161anc\u00ed byla biologick\u00e1 l\u00e9\u010dba.
\nA ta zabrala hned po prvn\u00ed infuzi.<\/p>\n

„Dnes m\u016f\u017eu zase pracovat a d\u011blat v\u0161echno, i jezdit na koni, co\u017e p\u0159edt\u00edm ne\u0161lo, proto\u017ee jsem nesev\u0159ela uzdu,“ vypr\u00e1v\u00ed l\u00e9ka\u0159ka.<\/p>\n

P\u0159esto\u017ee zrovna u revmatoidn\u00ed artritidy je p\u0159\u00ednos biologick\u00fdch l\u00e9k\u016f i v porovn\u00e1n\u00ed s jejich vysokou cenou jasn\u00fd, proto\u017ee pacient neskon\u010d\u00ed v invalidn\u00edm d\u016fchodu, ale m\u016f\u017ee norm\u00e1ln\u011b pracovat, l\u00e9\u010d\u00ed se v \u010cesku biologicky jen \u010d\u00e1st pacient\u016f. „Ze 3 148 pacient\u016f je na biologick\u00e9 l\u00e9\u010db\u011b 1 771,“ \u0159\u00edk\u00e1 Karel Pavelka z Revmatologick\u00e9ho \u00fastavu.<\/p>\n

D\u016fvod je jasn\u00fd: z finan\u010dn\u00edch d\u016fvod\u016f se k l\u00e9\u010db\u011b dostanou jen ti pacienti, u nich\u017e v\u0161echno ostatn\u00ed selhalo. Jen VZP loni zaplatila za biologickou l\u00e9\u010dbu p\u0159es t\u0159i a p\u016fl miliardy korun.<\/p>\n

Lenka Petr\u00e1\u0161ov\u00e1
\nMlad\u00e1 fronta DNES<\/p>\n","protected":false},"excerpt":{"rendered":"

Biologick\u00e1 l\u00e9\u010dba je drah\u00e1, ale \u010dasto jedin\u00e1 mo\u017en\u00e1. Podle v\u00fdrobc\u016f l\u00e9\u010div pr\u00e1v\u011b t\u011bmto l\u00e9k\u016fm pat\u0159\u00ed budoucnost. Ve v\u00fdvoji je moment\u00e1ln\u011b v\u00edce ne\u017e 900 nov\u00fdch biologick\u00fdch […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,9],"tags":[],"class_list":["post-9437","post","type-post","status-publish","format-standard","hentry","category-zdravi","category-zpravy"],"_links":{"self":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/9437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9437"}],"version-history":[{"count":0,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=\/wp\/v2\/posts\/9437\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.invarena.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}